Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Costanza Lo Cascio"'
Autor:
Costanza Lo Cascio, Tigran Margaryan, Ernesto Luna-Melendez, James B. McNamara, Connor I. White, William Knight, Saisrinidhi Ganta, Zorana Opachich, Claudia Cantoni, Wonsuk Yoo, Nader Sanai, Artak Tovmasyan, Shwetal Mehta
Publikováno v:
JCI Insight, Vol 8, Iss 22 (2023)
Histone deacetylase (HDAC) inhibitors have garnered considerable interest for the treatment of adult and pediatric malignant brain tumors. However, owing to their broad-spectrum nature and inability to effectively penetrate the blood-brain barrier, H
Externí odkaz:
https://doaj.org/article/fde3c2b5ee5b4f4fac16366a31d2b804
Autor:
Emmanuela A. Adjei‐Sowah, Samantha A. O'Connor, Jaimeson Veldhuizen, Costanza Lo Cascio, Christopher Plaisier, Shwetal Mehta, Mehdi Nikkhah
Publikováno v:
Advanced Science, Vol 9, Iss 21, Pp n/a-n/a (2022)
Abstract The perivascular niche (PVN) is a glioblastoma tumor microenvironment (TME) that serves as a safe haven for glioma stem cells (GSCs), and acts as a reservoir that inevitably leads to tumor recurrence. Understanding cellular interactions in t
Externí odkaz:
https://doaj.org/article/2b3e5fa4d610453cbd18c3e6dc9e5779
Autor:
Costanza Lo Cascio, James B. McNamara, Ernesto L. Melendez, Erika M. Lewis, Matthew E. Dufault, Nader Sanai, Christopher L. Plaisier, Shwetal Mehta
Publikováno v:
JCI Insight, Vol 6, Iss 17 (2021)
Glioblastoma (GBM) is characterized by an aberrant yet druggable epigenetic landscape. One major family of epigenetic regulators, the histone deacetylases (HDACs), are considered promising therapeutic targets for GBM due to their repressive influence
Externí odkaz:
https://doaj.org/article/0c28bf317c584da09eb9a6ee5bd8d523
Autor:
Shiv K. Singh, Roberto Fiorelli, Robert Kupp, Sindhu Rajan, Emily Szeto, Costanza Lo Cascio, Cecile L. Maire, Yu Sun, John A. Alberta, Jennifer M. Eschbacher, Keith L. Ligon, Michael E. Berens, Nader Sanai, Shwetal Mehta
Publikováno v:
Cell Reports, Vol 16, Iss 4, Pp 950-966 (2016)
In glioblastoma, invasion and proliferation are presumed to be mutually exclusive events; however, the molecular mechanisms that mediate this switch at the cellular level remain elusive. Previously, we have shown that phospho-OLIG2, a central-nervous
Externí odkaz:
https://doaj.org/article/ad5978bda5ba4c749fa2b28df1ebe0b1
Autor:
Shiv K. Singh, Roberto Fiorelli, Robert Kupp, Sindhu Rajan, Emily Szeto, Costanza Lo Cascio, Cecile L. Maire, Yu Sun, John A. Alberta, Jennifer M. Eschbacher, Keith L. Ligon, Michael E. Berens, Nader Sanai, Shwetal Mehta
Publikováno v:
Cell Reports, Vol 19, Iss 11, Pp 2410-2412 (2017)
Externí odkaz:
https://doaj.org/article/2afec7982ff047699ffad069f7922f86
Autor:
Costanza Lo Cascio, Tigran Margaryan, Ernesto Luna Melendez, James B. McNamara, Connor I. White, William Knight, Saisrinidhi Ganta, Zorana Opachich, Wonsuk Yoo, Nader Sanai, Artak Tovmasyan, Shwetal Mehta
In recent years, histone deacetylase inhibitors (HDACi) have garnered considerable interest for the treatment of adult and pediatric malignant brain tumors. However, owing to their broad-spectrum nature and inability to effectively penetrate the bloo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bc4ab56dacefae808da6f2c208e663de
https://doi.org/10.1101/2022.11.09.515859
https://doi.org/10.1101/2022.11.09.515859
Autor:
Costanza Lo Cascio, Tigran Margaryan, Ernesto Luna Melendez, James McNamara, William Knight, Connor White, Zorana Opachich, Niddhi Ganta, Alexis Giff, Nader Sanai, Artak Tovmasyan, Shwetal Mehta
Publikováno v:
Neuro-Oncology. 24:vii216-vii216
Glioblastoma (GBM) is characterized by an aberrant yet druggable epigenetic landscape. Class I HDACs mediate chromatin compaction and are frequently overexpressed in GBM. Hence, there has been considerable interest in HDAC inhibitors (HDACi) for the
Autor:
James McNamara, Ernesto Luna Melendez, Nader Sanai, Matthew E. Dufault, Shwetal Mehta, Erika M. Lewis, Costanza Lo Cascio, Christopher L. Plaisier
Publikováno v:
JCI Insight
Glioblastoma (GBM) is characterized by an aberrant yet druggable epigenetic landscape. One major family of epigenetic regulators, the histone deacetylases (HDACs), are considered promising therapeutic targets for GBM due to their repressive influence
Autor:
Costanza Lo Cascio, Tigran Margaryan, Ernesto Luna Melendez, James McNamara, William Knight, Sarah Himes, Connor White, Alexis Giff, Jesus Peralta, Nader Sanai, Artak Tovmasyan, Shwetal Mehta
Publikováno v:
Cancer Research. 82:349-349
Glioblastoma (GBM), the most common and aggressive primary brain tumor affecting adults, is characterized by an aberrant yet druggable epigenetic landscape. Class I histone deacetylases (HDACs) mediate chromatin compaction and are frequently overexpr
Publikováno v:
Neuro Oncol
OLIG2 is a central nervous system-specific transcription factor that is expressed in almost all diffuse gliomas. It is also one of the key core transcription factors that can reprogram differentiated glioma cells to highly tumorigenic glioma stem-lik
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::669f94c0cb62697fafa2bbd25ab1bad9
https://europepmc.org/articles/PMC6847567/
https://europepmc.org/articles/PMC6847567/