Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Costanza L Vallerga"'
Epigenome wide association study of response to methotrexate in early rheumatoid arthritis patients.
Autor:
Helen R Gosselt, Costanza L Vallerga, Pooja R Mandaviya, Erik Lubberts, Johanna M W Hazes, Robert de Jonge, Sandra G Heil
Publikováno v:
PLoS ONE, Vol 16, Iss 3, p e0247709 (2021)
AimTo identify differentially methylated positions (DMPs) and regions (DMRs) that predict response to Methotrexate (MTX) in early rheumatoid arthritis (RA) patients.Materials and methodsDNA from baseline peripheral blood mononuclear cells was extract
Externí odkaz:
https://doaj.org/article/736434ab899447cabb519e42f9e12903
Autor:
Magdalena Beran, Willemijn J. Jansen, Julie E. Oomens, Justine E.F. Moonen, Pieter Jelle Visser, Martijn A. Huisman, Almar A.L. Kok, Astrid C.J. Nooyens, W.M. Monique Verschuren, Coen D.A. Stehouwer, Casper Schalkwijk, Sebastian Köhler, Martin van Boxtel, Marian Beekman, P. Eline Slagboom, Frank J. Wolters, M. Arfan Ikram, Costanza L. Vallerga, Joyce B.J. van Meurs, Mohsen Ghanbari, Jet M.J. Vonk, Mirjam I. Geerlings, Thomas T. van Sloten, Miranda T. Schram
Publikováno v:
Cerebral Circulation - Cognition and Behavior, Vol 6, Iss , Pp 100271- (2024)
Introduction: Endothelial dysfunction has various detrimental effects on the brain that may lead to cognitive decline. However, data on the direct association between endothelial dysfunction and cognitive performance in humans are scarce. The aim of
Externí odkaz:
https://doaj.org/article/011366f97831404883e57f2adebe9ee8
Autor:
Qian Zhang, Costanza L. Vallerga, Rosie M. Walker, Tian Lin, Anjali K. Henders, Grant W. Montgomery, Ji He, Dongsheng Fan, Javed Fowdar, Martin Kennedy, Toni Pitcher, John Pearson, Glenda Halliday, John B. Kwok, Ian Hickie, Simon Lewis, Tim Anderson, Peter A. Silburn, George D. Mellick, Sarah E. Harris, Paul Redmond, Alison D. Murray, David J. Porteous, Christopher S. Haley, Kathryn L. Evans, Andrew M. McIntosh, Jian Yang, Jacob Gratten, Riccardo E. Marioni, Naomi R. Wray, Ian J. Deary, Allan F. McRae, Peter M. Visscher
Publikováno v:
Genome Medicine, Vol 11, Iss 1, Pp 1-11 (2019)
Abstract Background DNA methylation changes with age. Chronological age predictors built from DNA methylation are termed ‘epigenetic clocks’. The deviation of predicted age from the actual age (‘age acceleration residual’, AAR) has been repor
Externí odkaz:
https://doaj.org/article/46389891d1954dbea4f0f5efb1f60145
Autor:
Yasir J. Abozaid, Ibrahim Ayada, Laurens A. van Kleef, Costanza L. Vallerga, Qiuwei Pan, Willem P. Brouwer, M. Arfan Ikram, Joyce Van Meurs, Robert J. de Knegt, Mohsen Ghanbari
Publikováno v:
Hepatology.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a82a7b3d274b8d6b825388e0e51f9c72
https://doi.org/10.1097/hep.0000000000000300
https://doi.org/10.1097/hep.0000000000000300
Autor:
Lieke M. Kuiper, Harmke A. Polinder-Bos, Daniele Bizzarri, Dina Vojinovic, Costanza L. Vallerga, Marian Beekman, Martijn E.T. Dollé, Mohsen Ghanbari, Trudy Voortman, Marcel J.T. Reinders, W.M. Monique Verschuren, P. Eline Slagboom, Erik B. van den Akker, Joyce B.J. van Meurs
Biological age captures a person’s age-related risk of unfavorable outcomes using biophysiological information. Multivariate biological age measures include frailty scores and molecular biomarkers. These measures are often studied in isolation, but
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5485ebb74db3428021552de72b5aea05
https://doi.org/10.1101/2022.12.05.22282968
https://doi.org/10.1101/2022.12.05.22282968
Autor:
Ingrid A Szilagyi, Costanza L Vallerga, Cindy G Boer, Dieuwke Schiphof, M Arfan Ikram, Sita M A Bierma-Zeinstra, Joyce B J van Meurs
Publikováno v:
Rheumatology (Oxford, England), 62(3), 1286-1295. Oxford University Press
Objectives The aim of this study was to identify biomarkers for radiographic OA severity and progression acting within the inflammation and metabolic pathways. Methods For 3517 Rotterdam Study participants, 184 plasma protein levels were measured usi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99be96cd70bec2b6b0822da7c9d893ed
https://pubmed.ncbi.nlm.nih.gov/35924962
https://pubmed.ncbi.nlm.nih.gov/35924962
Autor:
Anjali K. Henders, Marta F. Nabais, Steven R. Bentley, Ting Qi, John C. Dalrymple-Alford, Jacob Gratten, Glenda M. Halliday, Qian Zhang, Leanne Wallace, Allan F. McRae, Costanza L. Vallerga, Peter A. Silburn, Yu-Hsuan Chuang, Steve Horvath, Tim J. Anderson, Futao Zhang, Jian Yang, Grant W. Montgomery, George D. Mellick, Beate Ritz, Naomi R. Wray, John F. Pearson, Irfahan Kassam, Martin A. Kennedy, John B.J. Kwok, Simon J.G. Lewis, Javed Fowdar, Peter M. Visscher, Ian B. Hickie, Toni L. Pitcher
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-10 (2020)
Nature Communications
Nature Communications
An improved understanding of etiological mechanisms in Parkinson’s disease (PD) is urgently needed because the number of affected individuals is projected to increase rapidly as populations age. We present results from a blood-based methylome-wide
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3b3c219641bf4df29f9c1acdeaacb72
http://link.springer.com/article/10.1038/s41467-020-15065-7
http://link.springer.com/article/10.1038/s41467-020-15065-7
Autor:
Riccardo E. Marioni, Peter A. Silburn, John B.J. Kwok, Ian J. Deary, Simon J.G. Lewis, Dongsheng Fan, Qian Zhang, David J. Porteous, Tian Lin, Alison D. Murray, Ji He, Glenda M. Halliday, Kathryn L. Evans, Sarah E. Harris, Tim J. Anderson, Grant W. Montgomery, John F. Pearson, Toni L. Pitcher, Peter M. Visscher, Chris Haley, Ian B. Hickie, Naomi R. Wray, Andrew M. McIntosh, Javed Fowdar, Anjali K. Henders, George D. Mellick, Costanza L. Vallerga, Allan F. McRae, Martin A. Kennedy, Jian Yang, Paul Redmond, Jacob Gratten, Rosie M. Walker
Publikováno v:
Genome Medicine, Vol 11, Iss 1, Pp 1-11 (2019)
Genome Medicine
Zhang, Q, Vallerga, C L, Walker, R M, Lin, T, Henders, A K, Montgomery, G W, He, J, Fan, D, Fowdar, J, Kennedy, M, Pitcher, T, Pearson, J, Halliday, G, Kwok, J B, Hickie, I, Lewis, S, Anderson, T, Silburn, P A, Mellick, G D, Harris, S E, Redmond, P, Murray, A D, Porteous, D J, Haley, C S, Evans, K L, Mcintosh, A M, Yang, J, Gratten, J, Marioni, R E, Wray, N R, Deary, I J, Mcrae, A F & Visscher, P M 2019, ' Improved precision of epigenetic clock estimates across tissues and its implication for biological ageing ', Genome Medicine, vol. 11, no. 1, 54 . https://doi.org/10.1186/s13073-019-0667-1
Genome Medicine
Zhang, Q, Vallerga, C L, Walker, R M, Lin, T, Henders, A K, Montgomery, G W, He, J, Fan, D, Fowdar, J, Kennedy, M, Pitcher, T, Pearson, J, Halliday, G, Kwok, J B, Hickie, I, Lewis, S, Anderson, T, Silburn, P A, Mellick, G D, Harris, S E, Redmond, P, Murray, A D, Porteous, D J, Haley, C S, Evans, K L, Mcintosh, A M, Yang, J, Gratten, J, Marioni, R E, Wray, N R, Deary, I J, Mcrae, A F & Visscher, P M 2019, ' Improved precision of epigenetic clock estimates across tissues and its implication for biological ageing ', Genome Medicine, vol. 11, no. 1, 54 . https://doi.org/10.1186/s13073-019-0667-1
Background DNA methylation changes with age. Chronological age predictors built from DNA methylation are termed ‘epigenetic clocks’. The deviation of predicted age from the actual age (‘age acceleration residual’, AAR) has been reported to be
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e23aea39874f3892565dd03cfa18b71
http://link.springer.com/article/10.1186/s13073-019-0667-1
http://link.springer.com/article/10.1186/s13073-019-0667-1
Autor:
Lisa M. Shulman, Hirotaka Iwaki, David A. Hinds, Jacob Gratten, Huw R. Morris, Joseph Jankovic, Costanza L. Vallerga, J. Raphael Gibbs, John Hardy, Javier Simón-Sánchez, Johan Marinus, Thomas Gasser, Peter Heutink, Alexis Brice, Andrew B. Singleton, Dena G. Hernandez, Jean-Christophe Corvol, Karl Heilbron, Donald G. Grosset, Manu Sharma, Ari Siitonen, Peter M. Visscher, Sonja W. Scholz, Pentti J. Tienari, Lynne Krohn, Mathias Toft, Manuela Tan, Johanna Eerola-Rautio, Mike A. Nalls, Jacobus J. van Hilten, Lasse Pihlstrøm, Claudia Schulte, Ziv Gan-Or, Sara Bandres-Ciga, Cornelis Blauwendraat, Hampton L. Leonard, Alastair J. Noyce, Kari Majamaa, Rainer von Coelln, N Wood, Joshua M. Shulman, Suzanne Lesage
Publikováno v:
Movement disorders 34(6), 866-875 (2019). doi:10.1002/mds.27659
Mov Disord
Movement Disorders, 34(6), 866-875
Mov Disord
Movement Disorders, 34(6), 866-875
Background Increasing evidence supports an extensive and complex genetic contribution to PD. Previous genome-wide association studies (GWAS) have shed light on the genetic basis of risk for this disease. However, the genetic determinants of PD age at
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4bd5e3ef56b4f970b8d74fbe53651338
https://doi.org/10.1002/mds.27659
https://doi.org/10.1002/mds.27659
Autor:
Simon J.G. Lewis, Jan H. Veldink, Iwona Kłoszewska, Jonathan Mill, Nicola J. Armstrong, Eilis Hannon, Allan F. McRae, Simon M. Laws, Pamela J. Shaw, Katie Lunnon, Pamela A. McCombe, Ammar Al-Chalabi, Anjali K. Henders, Marta F. Nabais, Alfredo Iacoangeli, Glenda M. Halliday, Susan Mathers, John B.J. Kwok, Ashley R. Jones, Anna J. Stevenson, Ian B. Hickie, Tian Lin, Cristopher E. Shaw, Ian P. Blair, Hilkka Soininen, Wouter van Rheenen, Karen E. Morrison, Jacob Gratten, Toni L. Pitcher, Ian J. Deary, Janou A. Y. Roubroeks, Shyuan T. Ngo, Tim J. Anderson, Sarah Furlong, Merrilee Needham, Peter M. Visscher, Peter A. Silburn, Ramona A. J. Zwamborn, Karen A. Mather, Patrizia Mecocci, Naomi R. Wray, Roger Pamphlett, Paul J. Hop, Garth A. Nicholson, John F. Pearson, Jian Yang, Simon Lovestone, Kelly L. Williams, Costanza L. Vallerga, Magda Tsolaki, Ehsan Pishva, Robert D. Henderson, Futao Zhang, Grant W. Montgomery, Bruno Vellas, Robert F. Hillary, Steven R. Bentley, John C. Dalrymple-Alford, Frederik J. Steyn, Riccardo E. Marioni, Dominic B. Rowe, Leanne Wallace, Leonard H. van den Berg, Aleksey Shatunov, Sarah E. Harris, Perminder S. Sachdev, Fleur C. Garton, George D. Mellick, Javed Fowder, Martin A. Kennedy
Publikováno v:
Nabais, M F, Laws, S M, Lin, T, Vallerga, C L, Armstrong, N J, Blair, I P, Kwok, J B, Mather, K A, Mellick, G D, Sachdev, P S, Wallace, L, Henders, A K, Zwamborn, R A J, Hop, P J, Lunnon, K, Pishva, E, Roubroeks, J A Y, Soininen, H, Tsolaki, M, Mecocci, P, Lovestone, S, Kłoszewska, I, Vellas, B, Furlong, S, Garton, F C, Henderson, R D, Mathers, S, Mccombe, P A, Needham, M, Ngo, S T, Nicholson, G, Pamphlett, R, Rowe, D B, Steyn, F J, Williams, K L, Anderson, T J, Bentley, S R, Dalrymple-alford, J, Fowder, J, Gratten, J, Halliday, G, Hickie, I B, Kennedy, M, Lewis, S J G, Montgomery, G W, Pearson, J, Pitcher, T L, Silburn, P, Zhang, F, Visscher, P M, Yang, J, Stevenson, A J, Hillary, R F, Marioni, R E, Harris, S E, Deary, I J, Jones, A R, Shatunov, A, Iacoangeli, A, Van Rheenen, W, Van Den Berg, L H, Shaw, P J, Shaw, C E, Morrison, K E, Al-chalabi, A, Veldink, J H, Hannon, E, Mill, J, Wray, N R & Mcrae, A F 2021, ' Meta-analysis of genome-wide DNA methylation identifies shared associations across neurodegenerative disorders ', Genome Biology, vol. 22, no. 1 . https://doi.org/10.1186/s13059-021-02275-5
Genome Biology, Vol 22, Iss 1, Pp 1-30 (2021)
Genome Biology
Genome Biology, 22(1):90. BioMed Central Ltd.
Australian Imaging Biomarkers and Lifestyle study & Alzheimer’s Disease Neuroimaging Initiative 2021, ' Meta-analysis of genome-wide DNA methylation identifies shared associations across neurodegenerative disorders ', Genome Biology, vol. 22, 90 . https://doi.org/10.1186/s13059-021-02275-5
Genome Biology, Vol 22, Iss 1, Pp 1-30 (2021)
Genome Biology
Genome Biology, 22(1):90. BioMed Central Ltd.
Australian Imaging Biomarkers and Lifestyle study & Alzheimer’s Disease Neuroimaging Initiative 2021, ' Meta-analysis of genome-wide DNA methylation identifies shared associations across neurodegenerative disorders ', Genome Biology, vol. 22, 90 . https://doi.org/10.1186/s13059-021-02275-5
Background People with neurodegenerative disorders show diverse clinical syndromes, genetic heterogeneity, and distinct brain pathological changes, but studies report overlap between these features. DNA methylation (DNAm) provides a way to explore th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::222e9540511330ced2d46144bc1f420e
https://zenodo.org/record/4643029
https://zenodo.org/record/4643029