mtDNA control region and D-HPLC analysis: a method to evaluate the mating system in Syngnathidae (Teleostei)

Autor: Alberto Addis, Costantino Motzo, Paolo Francalacci, Daria Sanna, Marcella Carcupino, Francesca Biagi

Publikováno v: Marine Biology. 153:269-275

Mitochondrial DNA (mtDNA) has been used extensively in animals for phylogenetic and population studies but it has been applied only occasionally to mating systems analysis, where nuclear markers are usually preferred. We used denaturing-high performa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ce354d0d5f0683c23f1f630fda28830e
https://doi.org/10.1007/s00227-007-0810-1

Association of the T-cell regulatory gene CTLA4 with susceptibility to autoimmune disease

Autor: Neil Walker, Constantin Ionescu-Tirgoviste, Kathleen M Gillespie, Cristian Guja, David A. Savage, Jane Rogers, Eva Tuomilehto-Wolf, Christopher Patterson, Dag E. Undlien, Laurence B. Peterson, H Ueda, Michael L. Metzker, Francesco Cucca, Jaakko Tuomilehto, C Bordin, R Nithiyananthan, Hywel Snook, Amit Allahabadia, Simon G. Gregory, Helen E. Rance, Jayne A. Franklyn, John A. Todd, A C Lam, F Payne, John S. Hulme, Laura Esposito, Polly J. Bingley, Anne Smith, Giselle Chamberlain, Dennis Carson, Gough Scl., Kjersti S. Rønningen, Deborah J. Smyth, G Di Genova, Barry C. Healy, Alexander P. Maxwell, Joanne M. Heward, Sarah Nutland, Howson Jmm., Christopher E. Lowe, Twells Rcj., Hunter Kmd., Sarah Howlett, Heather J. Cordell, Ingrid Dahlman, J F Hess, David Clayton, Linda S. Wicker, Mathias H. Herr, Vincent H. Everett, Costantino Motzo, Dan Rainbow, Luc J. Smink

Publikováno v: Ueda, H, Howson, J M M, Esposito, L, Heward, J, Snook, H, Chamberlain, G, Rainbow, D B, Hunter, K M D, Smith, A N, Di Genova, G, Herr, M H, Dahlman, I, Payne, F, Smyth, D, Lowe, C, Twells, R C J, Howlett, S, Healy, B, Nutland, S, Rance, H E, Everett, V, Smink, L J, Lam, A C, Cordell, H J, Walker, N M, Bordin, C, Hulme, J, Motzo, C, Cucca, F, Hess, J F, Metzker, M L, Rogers, J, Gregory, S, Allahabadia, A, Nithiyananthan, R, Tuomilehto-Wolf, E, Tuomilehto, J, Bingley, P, Gillespie, K M, Undlien, D E, Ronningen, K S, Guja, C, Ionescu-Tirgoviste, C, Savage, D, Maxwell, A, Carson, D, Patterson, C, Franklyn, J A, Clayton, D G, Peterson, L B, Wicker, L S, Todd, J A & Gough, S C L 2003, ' Association of the T-cell regulatory gene CTLA4 with susceptibility to autoimmune disease ' Nature, vol. 423 (6939), no. 6939, pp. 506-511 .

Genes and mechanisms involved in common complex diseases, such as the autoimmune disorders that affect approximately 5% of the population, remain obscure. Here we identify polymorphisms of the cytotoxic T lymphocyte antigen 4 gene (CTLA4)--which enco

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4278267511fa630d26092f47f30edae
https://doi.org/10.1038/nature01621

Characterization of the electrophysiological and pharmacological effects of 4-iodo-2,6-diisopropylphenol, a propofol analogue devoid of sedative-anaesthetic properties

Autor: Costantino Motzo, Laura Dazzi, Andrea Latrofa, Giuseppe Trapani, Gaetano Liso, Mariangela Serra, Marcello Usala, Giovanni Biggio, Elisabetta Maciocco, Enrico Sanna

Publikováno v: British Journal of Pharmacology. 126:1444-1454

1. Several derivatives and analogues of the general anaesthetic 2,6-diisopropylphenol (propofol) have been recently synthesised with the aim of exploring the structure-activity relationships. 2. In the present study, the effects of one such compound,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::47e58116eba9ad34d9b7a948ac26c291
https://doi.org/10.1038/sj.bjp.0702449

Antagonism of isoniazid-induced convulsions by abecarnil in mice tolerant to diazepam

Autor: Cristina A. Ghiani, Giovanni Biggio, Costantino Motzo, Mariangela Serra, Maria Luisa Porceddu

Publikováno v: Pharmacology Biochemistry and Behavior. 52:249-254

The ability of the benzodiazepine receptor full agonist diazepam, the selective agonist abecarnil, and the partial agonist imidazenil to antagonize convulsions induced by isoniazid (200 mg/kg, SC) was studied in mice chronically treated with diazepam

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35250291e5fa7c45bb143f45c078acf7
https://doi.org/10.1016/0091-3057(94)00422-f

Long-term treatment with abecarnil fails to induce tolerance in mice

Autor: Cristina A. Ghiani, Costantino Motzo, Maria Luisa Perceddu, Mariangela Serra, Giovanni Biggio

Publikováno v: European Journal of Pharmacology. 259:1-6

The effects of long-term treatment (3 times a day for 4 weeks) with a pharmacologically active dose (0.1 mg/kg i.p.) of the novel anxiolytic, abecarnil, on exploratory behaviour and [35S]TBPS (t-butylbicyclophosphorothionate) binding were compared to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5cbdd2c3ccf97546f85045560ead86f7
https://doi.org/10.1016/0014-2999(94)90149-x