Hybrid Vigor: Importance of Hybrid λ Phages in Early Insights in Molecular Biology

Autor: Michael Feiss, Ryland Young, Jolene Ramsey, Sankar Adhya, Costa Georgopoulos, Roger W. Hendrix, Graham F. Hatfull, Eddie B. Gilcrease, Sherwood R. Casjens

Publikováno v: Microbiology and molecular biology reviews : MMBR.

Laboratory-generated hybrids between phage λ and related phages played a seminal role in establishment of the λ model system, which, in turn, served to develop many of the foundational concepts of molecular biology, including gene structure and con

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ef88b3b76d724cbe7d164ab5f1da15c
https://pubmed.ncbi.nlm.nih.gov/36165780

A recurrent de novo

Autor: Cagla, Cömert, Lauren, Brick, Debbie, Ang, Johan, Palmfeldt, Brandon F, Meaney, Mariya, Kozenko, Costa, Georgopoulos, Paula, Fernandez-Guerra, Peter, Bross

Publikováno v: Cold Spring Harbor Molecular Case Studies

Standardization of the use of next-generation sequencing for the diagnosis of rare neurological disorders has made it possible to detect potential disease-causing genetic variations, including de novo variants. However, the lack of a clear pathogenic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::e388e8be6d821db75edaa4355dad2eac
https://pubmed.ncbi.nlm.nih.gov/32532876

A recurrent de novo HSPD1 variant is associated with hypomyelinating leukodystrophy

Autor: Costa Georgopoulos, Lauren Brick, Paula Fernandez-Guerra, Peter Bross, Cagla Cömert, Johan Palmfeldt, Brandon F. Meaney, Mariya Kozenko, Debbie Ang

Publikováno v: Cömert, C, Brick, L, Ang, D, Palmfeldt, J, Meaney, B F, Kozenko, M, Georgopoulos, C, Fernandez-Guerra, P & Bross, P 2020, ' A recurrent de novo HSPD1 variant is associated with hypomyelinating leukodystrophy ', Cold Spring Harbor molecular case studies, vol. 6, no. 3 . https://doi.org/10.1101/mcs.a004879

Standardization of the use of next-generation sequencing for the diagnosis of rare neurological disorders has made it possible to detect potential disease-causing genetic variations, including de novo variants. However, the lack of a clear pathogenic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6220cf28ab1ea14b03503e17d9a4e7a0
https://doi.org/10.1101/mcs.a004879

Hsp 33 Controls Elongation Factor-Tu Stability and allows Escherichia coli growth in the absence of the major DnaK and Trigger Factor Chaperones

Autor: Joen Luirink, Marie Pierre Castanié-Cornet, Nicolas Bruel, Gregory Koningstein, Anne Marie Cirinesi, Costa Georgopoulos, Pierre Genevaux

Publikováno v: Journal of Biological Chemistry, 287, 44435-44446. American Society for Biochemistry and Molecular Biology Inc.
Journal of Biological Chemistry
Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 2012, 287 (53), pp.44435-46
Bruel, N, Castanié-Cornet, M P, Cirinesi, A M, Koningstein, G M, Georgopoulos, C, Luirink, J & Genevaux, P 2012, ' Hsp 33 Controls Elongation Factor-Tu Stability and allows Escherichia coli growth in the absence of the major DnaK and Trigger Factor Chaperones ', Journal of Biological Chemistry, vol. 287, pp. 44435-44446 . https://doi.org/10.1074/jbc.M112.418525

Intracellular de novo protein folding is assisted by cellular networks of molecular chaperones. In Escherichia coli, cooperation between the chaperones trigger factor (TF) and DnaK is central to this process. Accordingly, the simultaneous deletion of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9bbef97094f333715e049a869c34410
https://doi.org/10.1074/jbc.M112.418525

Mitochondrial Hsp60 Chaperonopathy Causes an Autosomal-Recessive Neurodegenerative Disorder Linked to Brain Hypomyelination and Leukodystrophy

Autor: Yardena Segev, Peter Bross, Alexandra Nemirovski, Dorit Goldsher, Costa Georgopoulos, Karl Skorecki, Bayan Heno, Daniella Magen, Debbie Ang, Sarit Ravid, Anthony Luder, Hanna Mandel, Eli Shahar, Ruth Gershoni-Baruch

Publikováno v: Magen, D, Georgopoulos, C, Bross, P, Ang, D, Segev, Y, Goldsher, D, Nemirovski, A, Shahar, E, Ravid, S, Luder, A, Heno, B, Gershoni-Baruch, R, Skorecki, K & Mandel, H 2008, ' Mitochondrial hsp60 chaperonopathy causes an autosomal-recessive neurodegenerative disorder linked to brain hypomyelination and leukodystrophy. ', American Journal of Human Genetics, vol. 83, no. 1, pp. 30-42 . https://doi.org/10.1016/j.ajhg.2008.05.016

Udgivelsesdato: 2008-Jul Hypomyelinating leukodystrophies (HMLs) are disorders involving aberrant myelin formation. The prototype of primary HMLs is the X-linked Pelizaeus-Merzbacher disease (PMD) caused by mutations in PLP1. Recently, homozygous mut

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::804a3a6a2d9b5cccb733704d3f035708
https://doi.org/10.1016/j.ajhg.2008.05.016