(-)-5-Demethoxygrandisin B a New Lignan from Virola surinamensis (Rol.) Warb. Leaves: Evaluation of the Leishmanicidal Activity by In Vitro and In Silico Approaches.

Autor: Paes SS; Institute of Exact and Natural Sciences, Federal University of Pará, Belém 66075-110, PA, Brazil., Silva-Silva JV; Laboratory of Protozoology, Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Rio de Janeiro 21041-250, RJ, Brazil.; Laboratory of Medicinal and Computational Chemistry, Institute of Physics of São Carlos, University of São Paulo, São Carlos 13418-900, SP, Brazil., Portal Gomes PW; Collaborative Mass Spectrometry Innovation Center, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, CA 92123, USA., Silva LOD; Department of Natural Sciences, Pará State University, Belém 66095-015, PA, Brazil., Costa APLD; Institute of Exact and Natural Sciences, Federal University of Pará, Belém 66075-110, PA, Brazil., Lopes Júnior ML; Institute of Exact and Natural Sciences, Federal University of Pará, Belém 66075-110, PA, Brazil., Hardoim DJ; Laboratory of Protozoology, Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Rio de Janeiro 21041-250, RJ, Brazil., Moragas-Tellis CJ; Laboratory of Natural Products for Public Health, Pharmaceutical Technology Institute, Farmanguinhos, Oswaldo Cruz Foundation, Rio de Janeiro 21040-900, RJ, Brazil., Taniwaki NN; Electron Microscopy Nucleus, Adolfo Lutz Institute, São Paulo 01246-000, SP, Brazil., Bertho AL; Laboratory of Immunoparasitology, Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Rio de Janeiro 21040-900, RJ, Brazil.; Flow Cytometry Core Facility, Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Rio de Janeiro 21040-900, RJ, Brazil., Molfetta FA; Laboratory of Molecular Modeling, Institute of Exact and Natural Sciences, Federal University of Pará, Belém 66075-110, PA, Brazil., Almeida-Souza F; Laboratory of Protozoology, Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Rio de Janeiro 21041-250, RJ, Brazil.; Postgraduate Program in Animal Science, State University of Maranhão, Sao Luis 65055-310, MA, Brazil., Santos LS; Institute of Exact and Natural Sciences, Federal University of Pará, Belém 66075-110, PA, Brazil., Calabrese KDS; Laboratory of Protozoology, Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Rio de Janeiro 21041-250, RJ, Brazil.

Publikováno v: Pharmaceutics [Pharmaceutics] 2023 Sep 07; Vol. 15 (9). Date of Electronic Publication: 2023 Sep 07.