Investigation of the structural requirements for N-methyl-D-aspartate receptor positive and negative allosteric modulators based on 2-naphthoic acid

Autor: Irvine, Mark W., Fang, Guangyu, Sapkota, Kiran, Burnell, Erica S., Volianskis, Arturas, Costa, Blaise M., Culley, Georgia, Collingridge, Graham L., Monaghan, Daniel T., Jane, David E.

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A glutamate concentration-biased allosteric modulator potentiates NMDA-induced ion influx in neurons.

Autor: Costa, Blaise M.^1,2,3 bcosta@vt.edu, Kwapisz, Lina Cortés¹, Mehrkens, Brittney¹, Bledsoe, Douglas N.¹, Vacca, Bryanna N.¹, Johnston, Tullia V.¹, Razzaq, Rehan², Manickam, Dhanasekaran⁴, Klein, Bradley G.^1,3

Publikováno v: Pharmacology Research & Perspectives. Oct2021, Vol. 9 Issue 5, p1-14. 14p.

Coumarin-3-carboxylic acid derivatives as potentiators and inhibitors of recombinant and native N-methyl-d-aspartate receptors

Autor: Irvine, Mark W., Costa, Blaise M., Volianskis, Arturas, Fang, Guangyu, Ceolin, Laura, Collingridge, Graham L., Monaghan, Daniel T., Jane, David E.

Publikováno v: In Neurochemistry International September 2012 61(4):593-600

Cranial manipulation affects cholinergic pathway gene expression in aged rats.

Autor: Anandakrishnan, Ramu, Tobey, Hope, Nguyen, Steven, Sandoval, Osscar, Klein, Bradley G., Costa, Blaise M.

Publikováno v: Journal of Osteopathic Medicine; Feb2022, Vol. 122 Issue 2, p95-103, 9p

Synthesis of a series of novel 3,9-disubstituted phenanthrenes as analogues of known N-methyl-D-aspartate receptor allosteric modulators

Autor: Irvine, Mark W., Fang, Guangyu, Eaves, Richard, Mayo-Martin, Maria B., Burnell, Erica S., Costa, Blaise M., Culley, Georgia R., Volianskis, Arturas, Collingridge, Graham L., Monaghan, Daniel T., Jane, David E.

Publikováno v: Irvine, M W, Fang, G, Eaves, R, Mayo-Martin, M B, Burnell, E S, Costa, B M, Culley, G R, Volianskis, A, Collingridge, G L, Monaghan, D T & Jane, D E 2015, ' Synthesis of a series of novel 3,9-disubstituted phenanthrenes as analogues of known N-methyl-D-aspartate receptor allosteric modulators ', Synthesis (Germany), vol. 47, no. 11, ss-2014-t0697-op, pp. 1593-1610 . https://doi.org/10.1055/s-0034-1380114

9-Substituted phenanthrene-3-carboxylic acids have been reported to have allosteric modulatory activity at the N-methyl-d-aspartate (NMDA) receptor. This receptor is activated by the excitatory neurotransmitter l-glutamate and has been implicated in

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https://research-information.bris.ac.uk/ws/files/88017668/sup_ss_2014_t0697_op_10_1055_s_0034_1380114.pdf