Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Cosmas O. Okoro"'
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 3, p 2532 (2023)
Several reviews of inhibitors of topoisomerase II have been published, covering research before 2018. Therefore, this review is focused primarily on more recent publications with relevant points from the earlier literature. Topoisomerase II is an est
Externí odkaz:
https://doaj.org/article/780c557a96084dd19386cb9075f12585
Publikováno v:
Applied Sciences, Vol 2, Iss 2, Pp 368-374 (2012)
This article describes one-pot synthesis of new fluorinated hexahydroquinoline derivatives via unsymmetric Hantzsch reaction involving 5-trifluoromethyl-1,3-cyclohexanedione, aldehydes, acetoacetate ester, and ammonium acetate in trifluoroethanol (TF
Externí odkaz:
https://doaj.org/article/8b06c20a750548c093d676331a34a8f6
Publikováno v:
Acta Crystallographica Section E, Vol 67, Iss 8, Pp o2052-o2052 (2011)
In the title compound, C14H8Br2F3NO, the molecule is disordered across an approximate non-crystallographic mirror plane, which is in the plane of the fused ring system [The tetrahedral C atom bearing the trifluormethyl substituent is disordered with
Externí odkaz:
https://doaj.org/article/68069391481a447ab65f3ef3f0a04f63
Autor:
Cosmas O. Okoro, John Apraku
Publikováno v:
Bioorganic & Medicinal Chemistry. 27:161-166
Inspite of progress made for the discovery of novel antiepileptic drugs, epilepsy remains an unmet medical need. We synthesized nine trifluoromethylated enaminone derivatives and tested them for their anticonvulsant activity using maximal electroshoc
Publikováno v:
International Journal of Organic Chemistry. :121-129
Xanthene and Xanthenediones are structural components of several bioactive and semi-synthetic molecules. This work described an expeditious synthesis of novel and hitherto unreported bis-trifluoromethyl xanthene dione derivatives. The reaction of two
Publikováno v:
Letters in Drug Design & Discovery. 10:1024-1031
Autor:
Adeayo O. Ajala, Cosmas O. Okoro
Publikováno v:
Open Journal of Medicinal Chemistry. :43-49
Topomer CoMFA models have been used to optimize the potency of 15 biologically active acridone derivatives se- lected from the literature. Their 3D chemical structures were sliced into three acyclic R groups, to produce a fragment that is present in
Publikováno v:
Tetrahedron Letters. 52:5297-5300
A series of substituted dibenzalacetones prepared using standard procedures were condensed with 5-methyl, 5-phenyl, and 5-trifluoromethyl-1,3-cyclohexanediones respectively, in toluene containing BF 3 ·OEt as the Lewis acid catalyst. The reaction wa
Autor:
Takeisha Farmer, Cosmas O. Okoro, Patrice L. Jackson, Rhonda L. Richmond, Olugbeminiyi O. Fadeyi
Publikováno v:
Tetrahedron Letters. 47:7451-7454
A two-step procedure for the preparation of ethyl 4-amino-2-oxo-6-(trifluoromethyl)cyclohex-3-ene-1-carboxylate (enaminone) and methyl 4-hydroxy-2-oxo-6-(trifluoromethyl)cyclohex-3-ene-1-carboxylate (vinylogous acid) has been accomplished, using reac