Zobrazeno 1 - 10 of 38 pro vyhledávání: '"Cosma Spalluto"'
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Interrelationships Among Small Airways Dysfunction, Neutrophilic Inflammation, and Exacerbation Frequency in COPD
Autor: Alastair Watson, Kerry Day, Cosma Spalluto, Bruce Thompson, K Ostridge, Joy Conway, Doriana Cellura, Tom Wilkinson, Karl J. Staples
Publikováno v: Chest. 159:1391-1399
Background Small airways disease (SAD) is a key component of COPD and is a main contributing factor to lung function decline. Research Question Is SAD a key feature of frequent COPD exacerbators and is this related to airway inflammation? Study Desig
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c525f32d602ce810efcf666b4a66bed2
https://doi.org/10.1016/j.chest.2020.11.018
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3
Exercise Training Induces a Shift in Extracellular Redox Status with Alterations in the Pulmonary and Systemic Redox Landscape in Asthma
Autor: Bernadette O. Fernandez, Timothy Wallis, Doriana Cellura, Anna Freeman, Magdalena Minnion, Martin Feelisch, Sandy Jack, Alastair Watson, Tom Wilkinson, Michael P.W. Grocott, Karl J. Staples, A. Bates, Denny Z. H. Levett, Cosma Spalluto
Publikováno v: Antioxidants; Volume 10; Issue 12; Pages: 1926
Antioxidants
Antioxidants, Vol 10, Iss 1926, p 1926 (2021)
Redox dysregulation and oxidative stress have been implicated in asthma pathogenesis. Exercise interventions improve symptoms and reduce inflammation in asthma patients, but the underlying mechanisms remain unclear. We hypothesized that a personalise
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39cfd1ed9f9841a0445a674a16628f41
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4
S91 Gateway to the hidden zone: using pCLE to study relationships between elastin remodelling and small airways disease in the COPD lung
Autor: Cosma Spalluto, Tom Havelock, Tma Wilkinson, Michael J. Bennett, K Ostridge, Kcw Kong
Publikováno v: New insights into airways disease.
Introduction Small airways disease (SAD) is a hallmark of COPD and often precedes the development of airflow obstruction and clinically evident emphysema. SAD requires study however, this has been complicated by the absence of direct sampling and ima
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::53d0a156a6ceab7934b5e4e61ab4bd4e
https://doi.org/10.1136/thorax-2021-btsabstracts.97
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7
A novel ACE2 isoform is expressed in human respiratory epithelia and is upregulated in response to interferons and RNA respiratory virus infection
Autor: David A. Johnston, James Thompson, Gabrielle Wheway, Christopher McCormick, Jane S. Lucas, Liliya Nazlamova, Stephanie Reikine, Jelmer Legebeke, Vito Mennella, Jeanne-Marie Perotin, Martin Frank, Franco Conforti, Donna E. Davies, John Butler, Claire L. Jackson, Janice Coles, Kamran Tariq, Paul Skipp, Matthew Loxham, Cornelia Blume, Cosma Spalluto, Robert A. Ridley, Ratko Djukanovic, Diana Baralle, Lareb S. N. Dean, Max Crispin, Adnan Azim
Publikováno v: Nature Genetics
Nature Genetics, Nature Publishing Group, 2021, 53 (2), pp.205-214. ⟨10.1038/s41588-020-00759-x⟩
Angiotensin-converting enzyme 2 (ACE2) is the main entry point in airway epithelial cells for SARS-CoV-2. ACE2 binding to the SARS-CoV-2 protein spike triggers viral fusion with the cell plasma membrane, resulting in viral RNA genome delivery into th
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4bc03da2d5df1e5f9db7864d3f774a0c
https://hal.univ-reims.fr/hal-03330711
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8
Unfractionated heparin inhibits live wild type SARS-CoV-2 cell infectivity at therapeutically relevant concentrations
Autor: Julia A. Tree, Dave Singh, Michael J. Elmore, Clive P. Page, Tom Wilkinson, Naomi Coombes, Marcelo A. Lima, Cosma Spalluto, Jeremy E. Turnbull, Zhang Yang, Courtney J. Mycroft-West, Karl J. Staples, Richard Karlsson, Miles W. Carroll, Mark A. Skidmore, John Hogwood, Yen-Hsi Chen, Karen R. Buttigieg, Edwin A. Yates, Elaine Gray
Publikováno v: Tree, J A, Turnbull, J E, Buttigieg, K R, Elmore, M J, Coombes, N, Hogwood, J, Mycroft-West, C J, Lima, M A, Skidmore, M A, Karlsson, R, Chen, Y H, Yang, Z, Spalluto, C M, Staples, K J, Yates, E A, Gray, E, Singh, D, Wilkinson, T, Page, C P & Carroll, M W 2021, ' Unfractionated heparin inhibits live wild type SARS-CoV-2 cell infectivity at therapeutically relevant concentrations ', British Journal of Pharmacology, vol. 178, no. 3, pp. 626-635 . https://doi.org/10.1111/bph.15304
BRITISH JOURNAL OF PHARMACOLOGY
British Journal of Pharmacology
Background and Purpose: Currently, there are no licensed vaccines and limited antivirals for the treatment of COVID-19. Heparin (delivered systemically) is currently used to treat anticoagulant anomalies in COVID-19 patients. Additionally, in the Uni
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31b8338af1ae5e8e2e993e5869fee2f5
https://curis.ku.dk/portal/da/publications/unfractionated-heparin-inhibits-live-wild-type-sarscov2-cell-infectivity-at-therapeutically-relevant-concentrations(2c6da736-f287-4518-927b-1688baff6e3c).html
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9
Inflammatory phenotyping predicts clinical outcome in COVID-19
Autor: Hang T.T. Phan, Tom Wilkinson, Anna Freeman, S. Poole, Cosma Spalluto, Tristan W Clark, Doriana Cellura, Karl J. Staples, Nathan J Brendish, Florina Borca, Hannah Burke, Natasha Sheard, Beth Stuart, Sarah Williams
Publikováno v: Respiratory Research
Respiratory Research, Vol 21, Iss 1, Pp 1-9 (2020)
Background The COVID-19 pandemic has led to more than 760,000 deaths worldwide (correct as of 16th August 2020). Studies suggest a hyperinflammatory response is a major cause of disease severity and death. Identitfying COVID-19 patients with hyperinf
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::adc2303306549288102ced8bd7792cee
https://doi.org/10.1186/s12931-020-01511-z
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