Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Cosimo Damiano Altomare"'
Autor:
Nicola Amoroso, Nicola Gambacorta, Fabrizio Mastrolorito, Maria Vittoria Togo, Daniela Trisciuzzi, Alfonso Monaco, Ester Pantaleo, Cosimo Damiano Altomare, Fulvio Ciriaco, Orazio Nicolotti
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-10 (2023)
Abstract Chemical space modelling has great importance in unveiling and visualising latent information, which is critical in predictive toxicology related to drug discovery process. While the use of traditional molecular descriptors and fingerprints
Externí odkaz:
https://doaj.org/article/22d04a3dfd3a4452abe02f10a3f9eec3
Autor:
Paola Imbrici, Giuseppe d’Orsi, Massimo Carella, Orazio Nicolotti, Annamaria De Luca, Cosimo Damiano Altomare, Antonella Liantonio
Publikováno v:
Pharmacological Research, Vol 199, Iss , Pp 107012- (2024)
Externí odkaz:
https://doaj.org/article/ecb4e2944a1c40b383cb4a48a0d309e3
Autor:
Francesco Samarelli, Giovanni Graziano, Nicola Gambacorta, Elisabetta Anna Graps, Francesco Leonetti, Orazio Nicolotti, Cosimo Damiano Altomare
Publikováno v:
Viruses, Vol 16, Iss 3, p 450 (2024)
People affected by COVID-19 are exposed to, among others, abnormal clotting and endothelial dysfunction, which may result in deep vein thrombosis, cerebrovascular disorders, and ischemic and non-ischemic heart diseases, to mention a few. Treatments f
Externí odkaz:
https://doaj.org/article/3b3639f966f04df09d31d0a1a181e8be
Autor:
Marco Mele, Paola Imbrici, Antonietta Mele, Maria Vittoria Togo, Giorgia Dinoi, Michele Correale, Natale Daniele Brunetti, Orazio Nicolotti, Annamaria De Luca, Cosimo Damiano Altomare, Antonella Liantonio, Nicola Amoroso
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2023)
Introduction: Sodium-glucose cotransporter type 2 inhibitors (SGLT2i), gliflozins, play an emerging role for the treatment of heart failure with reduced left ventricular ejection fraction (HFrEF). Nevertheless, the effects of SGLT2i on ventricular re
Externí odkaz:
https://doaj.org/article/a167d0af5eea4eec83a75ba7ee490d95
Autor:
Alessia Carocci, Alexia Barbarossa, Rosalba Leuci, Antonio Carrieri, Leonardo Brunetti, Antonio Laghezza, Marco Catto, Francesco Limongelli, Sílvia Chaves, Paolo Tortorella, Cosimo Damiano Altomare, Maria Amélia Santos, Fulvio Loiodice, Luca Piemontese
Publikováno v:
Antioxidants, Vol 11, Iss 9, p 1631 (2022)
Alzheimer’s disease (AD) is a complex multi-factorial neurodegenerative disorder for which only few drugs (including donepezil, DPZ) are available as symptomatic treatments; thus, researchers are focusing on the development of innovative multi-targ
Externí odkaz:
https://doaj.org/article/04326891e7594e7e9cd5bfdb9016fafe
Autor:
Flavio De Maio, Mariagrazia Rullo, Modesto de Candia, Rosa Purgatorio, Gianfranco Lopopolo, Giulia Santarelli, Valentina Palmieri, Massimiliano Papi, Gabriella Elia, Erica De Candia, Maurizio Sanguinetti, Cosimo Damiano Altomare
Publikováno v:
Viruses, Vol 14, Iss 8, p 1730 (2022)
Coagulation factor Xa (fXa) and thrombin (thr) are widely expressed in pulmonary tissues, where they may catalyze, together with the transmembrane serine protease 2 (TMPRSS2), the coronaviruses spike protein (SP) cleavage and activation, thus enhanci
Externí odkaz:
https://doaj.org/article/37a09714cf044919b8b60db65bfe2bb4
Autor:
Antonio Lopalco, Annachiara Manni, Alexander Keeley, Shozeb Haider, Wenliang Li, Angela Lopedota, Cosimo Damiano Altomare, Nunzio Denora, Catherine Tuleu
Publikováno v:
Pharmaceutics, Vol 14, Iss 4, p 780 (2022)
Spironolactone (SPL), a potent anti-aldosterone steroidal drug used to treat several diseases in paediatric patients (e.g., hypertension, primary aldosteronism, Bartter’s syndrome, and congestive heart failure), is not available in child-friendly d
Externí odkaz:
https://doaj.org/article/9f2b9e1484f141758ebca327e1918266
Autor:
Isabella Bolognino, Antonio Carrieri, Rosa Purgatorio, Marco Catto, Rocco Caliandro, Benedetta Carrozzini, Benny Danilo Belviso, Maria Majellaro, Eddy Sotelo, Saverio Cellamare, Cosimo Damiano Altomare
Publikováno v:
Separations, Vol 9, Iss 1, p 7 (2021)
The enantiomeric separation of 15 racemic 4-aryl-3,4-dihydropyrimidin-2(1H)-one (DHP) alkoxycarbonyl esters, some of which proved to be highly active as A2B adenosine receptor antagonists, was carried out by HPLC on ChirobioticTM TAG, a chiral statio
Externí odkaz:
https://doaj.org/article/030debe0e380403d82fc8b7340addf08
Autor:
Benjamin Guieu, Cedric Lecoutey, Rémi Legay, Audrey Davis, Jana Sopkova de Oliveira Santos, Cosimo Damiano Altomare, Marco Catto, Christophe Rochais, Patrick Dallemagne
Publikováno v:
Molecules, Vol 26, Iss 1, p 80 (2020)
Alzheimer’s disease (AD) is a multifactorial neurodegenerative disease towards which pleiotropic approach using Multi-Target Directed Ligands is nowadays recognized as probably convenient. Among the numerous targets which are today validated agains
Externí odkaz:
https://doaj.org/article/9be4c6aa85634db592c868ceb0d9f6e3
Autor:
Laura Del Coco, Maria Majellaro, Angelina Boccarelli, Saverio Cellamare, Cosimo Damiano Altomare, Francesco Paolo Fanizzi
Publikováno v:
Molecules, Vol 25, Iss 15, p 3502 (2020)
A 1H-NMR-based metabolomic study was performed on MCF-7 cell lines treated with a novel nicotinamide derivative (DT-8) in comparison with two drugs characterized by a well-established mechanism of action, namely the DNA-metalating drug cisplatin (cis
Externí odkaz:
https://doaj.org/article/9447aa55943d4de1a686c25cf04a73fd