Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Cosimo D. Altomare"'
Autor:
Alisa A. Nevskaya, Rosa Purgatorio, Tatiana N. Borisova, Alexey V. Varlamov, Lada V. Anikina, Arina Yu. Obydennik, Elena Yu. Nevskaya, Mauro Niso, Nicola A. Colabufo, Antonio Carrieri, Marco Catto, Modesto de Candia, Leonid G. Voskressensky, Cosimo D. Altomare
Publikováno v:
Pharmaceuticals, Vol 17, Iss 4, p 539 (2024)
Previous studies have shown that some lamellarin-resembling annelated azaheterocyclic carbaldehydes and related imino adducts, sharing the 1-phenyl-5,6-dihydropyrrolo[2,1-a]isoquinoline (1-Ph-DHPIQ) scaffold, are cytotoxic in some tumor cells and may
Externí odkaz:
https://doaj.org/article/2d6fcacd9a5e4820a808bb200d14b6c9
Autor:
Rosa Purgatorio, Angelina Boccarelli, Leonardo Pisani, Modesto de Candia, Marco Catto, Cosimo D. Altomare
Publikováno v:
Antioxidants, Vol 13, Iss 1, p 133 (2024)
Polyphenolic compounds, encompassing flavonoids (e.g., quercetin, rutin, and cyanidin) and non-flavonoids (e.g., gallic acid, resveratrol, and curcumin), show several health-related beneficial effects, which include antioxidant, anti-inflammatory, he
Externí odkaz:
https://doaj.org/article/0eb9e2a816ad4e1293498861c7e656bf
Autor:
Marco Paolino, Modesto de Candia, Rosa Purgatorio, Marco Catto, Mario Saletti, Anna Rita Tondo, Orazio Nicolotti, Andrea Cappelli, Antonella Brizzi, Claudia Mugnaini, Federico Corelli, Cosimo D. Altomare
Publikováno v:
Molecules, Vol 28, Iss 15, p 5857 (2023)
The multitarget therapeutic strategy, as opposed to the more traditional ‘one disease-one target-one drug’, may hold promise in treating multifactorial neurodegenerative syndromes, such as Alzheimer’s disease (AD) and related dementias. Recentl
Externí odkaz:
https://doaj.org/article/cbf57ecfe1ff483c80c45536adf4d13c
Autor:
Larisa N. Kulikova, Ghulam Reza Raesi, Daria D. Levickaya, Rosa Purgatorio, Gabriella La Spada, Marco Catto, Cosimo D. Altomare, Leonid G. Voskressensky
Publikováno v:
Molecules, Vol 28, Iss 4, p 1662 (2023)
In this work, 2-alkyl-10-chloro-1,2,3,4-tetrahydrobenzo[b][1,6]naphthyridines were obtained and their reactivity was studied. Novel derivatives of the tricyclic scaffold, including 1-phenylethynyl (5), 1-indol-3-yl (8), and azocino[4,5-b]quinoline (1
Externí odkaz:
https://doaj.org/article/6afdb00d129c4f5daa281ef32651b50c
Autor:
Ignazio Schino, Mariangela Cantore, Modesto de Candia, Cosimo D. Altomare, Catarina Maria, João Barros, Vasco Cachatra, Patrícia Calado, Karina Shimizu, Adilson A. Freitas, Maria C. Oliveira, Maria J. Ferreira, José N. C. Lopes, Nicola A. Colabufo, Amélia P. Rauter
Publikováno v:
Pharmaceuticals, Vol 16, Iss 1, p 54 (2022)
Alzheimer’s Disease (AD) is characterized by a progressive cholinergic neurotransmission imbalance, with a decrease of acetylcholinesterase (AChE) activity followed by a significant increase of butyrylcholinesterase (BChE) in the later AD stages. B
Externí odkaz:
https://doaj.org/article/8753f9e020ec4afba27fb390b5193167
Autor:
Alexander A. Titov, Rosa Purgatorio, Arina Y. Obydennik, Anna V. Listratova, Tatiana N. Borisova, Modesto de Candia, Marco Catto, Cosimo D. Altomare, Alexey V. Varlamov, Leonid G. Voskressensky
Publikováno v:
Molecules, Vol 27, Iss 19, p 6276 (2022)
Transformations of 1-methoxymethylethynyl substituted isoquinolines triggered by terminal alkynes in alcohols were studied and new 3-benzazecine-containing compounds synthesized, such as 6-methoxymethyl-3-benzazecines incorporating an endocyclic C6
Externí odkaz:
https://doaj.org/article/9eb6beb5b79e444681424424fdc41cae
Autor:
Rosa Purgatorio, Nicola Gambacorta, Francesco Samarelli, Gianfranco Lopopolo, Modesto de Candia, Marco Catto, Orazio Nicolotti, Cosimo D. Altomare
Publikováno v:
Molecules, Vol 27, Iss 13, p 4269 (2022)
The rational discovery of new peptidomimetic inhibitors of the coagulation factor Xa (fXa) could help set more effective therapeutic options (to prevent atrial fibrillation). In this respect, we explored the conformational impact on the enzyme inhibi
Externí odkaz:
https://doaj.org/article/ce80e619bc244730a8c2370c8db82558
Autor:
Rosa Purgatorio, Nicola Gambacorta, Modesto de Candia, Marco Catto, Mariagrazia Rullo, Leonardo Pisani, Orazio Nicolotti, Cosimo D. Altomare
Publikováno v:
Molecules, Vol 26, Iss 17, p 5208 (2021)
Recently, the direct thrombin (thr) inhibitor dabigatran has proven to be beneficial in animal models of Alzheimer’s disease (AD). Aiming at discovering novel multimodal agents addressing thr and AD-related targets, a selection of previously and ne
Externí odkaz:
https://doaj.org/article/fe7b7f149e8d4f858c0245bc2c71b9fe
Autor:
Alisa A. Nevskaya, Lada V. Anikina, Rosa Purgatorio, Marco Catto, Orazio Nicolotti, Modesto de Candia, Leonardo Pisani, Tatiana N. Borisova, Almira R. Miftyakhova, Aleksey V. Varlamov, Elena Yu. Nevskaya, Roman S. Borisov, Leonid G. Voskressensky, Cosimo D. Altomare
Publikováno v:
Molecules, Vol 26, Iss 2, p 359 (2021)
Marine alkaloids belonging to the lamellarins family, which incorporate a 5,6-dihydro-1-phenylpyrrolo[2,1-a]isoquinoline (DHPPIQ) moiety, possess various biological activities, spanning from antiviral and antibiotic activities to cytotoxicity against
Externí odkaz:
https://doaj.org/article/18a924e640294c7d9662a70d8de2fee5
Autor:
Rosa Purgatorio, Nicola Gambacorta, Marco Catto, Modesto de Candia, Leonardo Pisani, Alba Espargaró, Raimon Sabaté, Saverio Cellamare, Orazio Nicolotti, Cosimo D. Altomare
Publikováno v:
Molecules, Vol 25, Iss 23, p 5773 (2020)
Thirty-six novel indole-containing compounds, mainly 3-(2-phenylhydrazono) isatins and structurally related 1H-indole-3-carbaldehyde derivatives, were synthesized and assayed as inhibitors of beta amyloid (Aβ) aggregation, a hallmark of pathophysiol
Externí odkaz:
https://doaj.org/article/ac0b4598acf445d5b30db80cd238b0e3