Zobrazeno 1 - 10
of 757
pro vyhledávání: '"Cosimi Ab"'
Autor:
Tatsuo Kawai, Rex Neal Smith, Cosimi Ab, Ivy A. Rosales, Benjamin Adam, B. Afzali, T. Oura, Michael Mengel, Masatoshi Matsunami, Robert B. Colvin
Publikováno v:
American Journal of Transplantation. 17:2841-2850
Molecular testing represents a promising adjunct for the diagnosis of antibody-mediated rejection (AMR). Here, we apply a novel gene expression platform in sequential formalin-fixed paraffin-embedded samples from nonhuman primate (NHP) renal transpla
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1d17d893f1b345c09874988437b1fdb
https://doi.org/10.1111/ajt.14327
https://doi.org/10.1111/ajt.14327
Publikováno v:
Clinical and Experimental Immunology. 189:190-196
Summary Induction of allograft tolerance has been considered the ultimate goal in organ transplantation. Although numerous protocols to induce allograft tolerance have been reported in mice, a chimerism-based approach through donor haematopoietic ste
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9af9485dd2628609184506d8dd7bcb21
https://doi.org/10.1111/cei.12969
https://doi.org/10.1111/cei.12969
Autor:
Rex Neal Smith, Dorothy Ndishabandi, Kento Kawai, James F. Markmann, Ji Lei, Cosimi Ab, Kiyohiko Hotta, A. Dehnadi, T. Oura, Ivy A. Rosales, Tatsuo Kawai
Publikováno v:
American Journal of Transplantation. 17:646-656
The lack of a reliable immunosuppressive regimen that effectively suppresses both renal and islet allograft rejection without islet toxicity hampers a wider clinical application of simultaneous islet-kidney transplantation (SIK). Seven MHC-mismatched
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19aa2ad585cab551d97b3725fa862fa2
https://doi.org/10.1111/ajt.13999
https://doi.org/10.1111/ajt.13999
Autor:
O. Nadazdin, Y. Yamada, Rex Neal Smith, Gilles Benichou, Emmanuel Zorn, Tatsuo Kawai, Svjetlan Boskovic, Robert B. Colvin, Joren C. Madsen, So Jin Lee, Cosimi Ab
Publikováno v:
American Journal of Transplantation. 15:3055-3066
Tolerance of allografts achieved in mice via stable mixed hematopoietic chimerism relies essentially on continuous elimination of developing alloreactive T cells in the thymus (central deletion). Conversely, while only transient mixed chimerism is ob
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d871d1a79498bdca290d0171b4196f98
https://doi.org/10.1111/ajt.13382
https://doi.org/10.1111/ajt.13382
Autor:
A. Dehnadi, Hajime Sasaki, Cosimi Ab, Ivy A. Rosales, Thaiss Cc, Tatsuo Kawai, Masatoshi Matsunami, T. Oura
Publikováno v:
Transplantation. 103(4)
BACKGROUND Although induction of durable mixed chimerism is required for murine skin allograft tolerance (TOL), renal allograft TOL has been achieved after induction of only transient mixed chimerism in nonhuman primates (NHPs) and humans. To better
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0a7e50e9b48062fcdac2efc45b623f6
https://pubmed.ncbi.nlm.nih.gov/30300283
https://pubmed.ncbi.nlm.nih.gov/30300283
Autor:
Ivy A. Rosales, Michael Mengel, Robert B. Colvin, Benjamin Adam, Masatoshi Matsunami, Tatsuo Kawai, Rex Neal Smith, T. Oura, Cosimi Ab
Tolerance induction to prevent allograft rejection is a long-standing clinical goal. However, convincing and dependable tolerance identification remains elusive. Hypothesizing that intragraft RNA expression is informative in both rejection and tolera
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::551359dad95c97333e39cb20ed60297a
https://europepmc.org/articles/PMC6021122/
https://europepmc.org/articles/PMC6021122/
Autor:
Rex Neal Smith, Benjamin Adam, Ivy A. Rosales, Michael Mengel, Robert B. Colvin, Tatsuo Kawai, Masatoshi Matsunami, T. Oura, Cosimi Ab
RNA transcript expression estimates are a promising method to study the mechanisms and classification of renal allograft rejections. Here we use the Nanostring platform to profile RNA expression in renal allografts in a nonhuman primate (NHP), the Cy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bbb19b2beb5ad8a8ebba4ed80e74b2a7
https://europepmc.org/articles/PMC5992005/
https://europepmc.org/articles/PMC5992005/
Autor:
Smita Asare, M. Howell, Z. Gao, Ignacio Sanz, Cosimi Ab, David H. Sachs, Megan Sykes, W. H. Marks, Allan D. Kirk, Thomas R. Spitzer, William J. Burlingham, Kenneth A. Newell, Chungwen Wei, Nina Tolkoff-Rubin, Alexander F. Rosenberg, M. Stahly, Stuart J. Knechtle, Laurence A. Turka, Deborah Phippard, Noha Lim, Adam Asare, Sai Kanaparthi, Tatsuo Kawai
Publikováno v:
American Journal of Transplantation. 15:2908-2920
Biomarkers of transplant tolerance would enhance the safety and feasibility of clinical tolerance trials and potentially facilitate management of patients receiving immunosuppression. To this end, we examined blood from spontaneously tolerant renal t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca4e283e4ba804674930b3b659c726d1
https://doi.org/10.1111/ajt.13480
https://doi.org/10.1111/ajt.13480
Autor:
Makoto Tonsho, David H. Sachs, O. Nadazdin, Rex Neal Smith, Svjetlan Boskovic, James S. Allan, A. Aoyama, So Jin Lee, Tatsuo Kawai, Joren C. Madsen, K. Capetta, Gilles Benichou, Cosimi Ab, Robert B. Colvin
Publikováno v:
American Journal of Transplantation. 15:2231-2239
While the induction of transient mixed chimerism has tolerized MHC-mismatched renal grafts in nonhuman primates and patients, this approach has not been successful for more immunogenic organs. Here, we describe a modified delayed-tolerance-induction
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f98b41642209b8dbdfd2585831261e6
https://doi.org/10.1111/ajt.13274
https://doi.org/10.1111/ajt.13274
Autor:
Choo Ng, Rex Neal Smith, David H. Sachs, John C. Wain, O. Nadazdin, Makoto Tonsho, A. Aoyama, So Jin Lee, James S. Allan, Robert B. Colvin, Joren C. Madsen, Timothy M. Millington, Gilles Benichou, Tatsuo Kawai, Cosimi Ab
Publikováno v:
American Journal of Transplantation. 15:1415-1420
Despite advances in surgical technique and clinical care, lung transplantation still remains a short-term solution for the treatment of end-stage lung disease. To date, there has been limited experience in experimental lung transplantation using nonh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90dfaffc32db26ac84892440a8cb881d
https://doi.org/10.1111/ajt.13130
https://doi.org/10.1111/ajt.13130