Zobrazeno 1 - 10
of 39
pro vyhledávání: '"Cosima Rhein"'
Publikováno v:
BMC Psychiatry, Vol 24, Iss 1, Pp 1-7 (2024)
Abstract Background Psychotherapy for post-traumatic stress disorder, in particular trauma-confronting psychotherapy, can be associated with increased stress. However, research on the somatic impact and psychosomatic interactions of these psychologic
Externí odkaz:
https://doaj.org/article/106dc92345e946baa7daef1434f823e9
Publikováno v:
Translational Psychiatry, Vol 13, Iss 1, Pp 1-7 (2023)
Abstract Posttraumatic stress disorder (PTSD) does not only have direct consequences for well-being, but it also comes with a significant risk for severe somatic health consequences. A number of previous studies have pointed to alterations in stress
Externí odkaz:
https://doaj.org/article/cfe78596602646848e78d9c094d28f48
Autor:
Benjamin Newcomb, Cosima Rhein, Izolda Mileva, Rasheed Ahmad, Christopher J. Clarke, Justin Snider, Lina M. Obeid, Yusuf A. Hannun
Publikováno v:
Journal of Lipid Research, Vol 59, Iss 7, Pp 1219-1229 (2018)
Acid sphingomyelinase (ASM) hydrolyzes sphingomyelin to produce the biologically active lipid ceramide. Previous studies have implicated ASM in the induction of the chemokine CCL5 in response to TNF-α however, the lipid mediator of this effect was n
Externí odkaz:
https://doaj.org/article/d929eab6ae61435eaff45ec3e1c7b339
Autor:
Cosima Rhein, Iulia Zoicas, Lena M. Marx, Stefanie Zeitler, Tobias Hepp, Claudia von Zimmermann, Christiane Mühle, Tanja Richter-Schmidinger, Bernd Lenz, Yesim Erim, Martin Reichel, Erich Gulbins, Johannes Kornhuber
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 11, p 5700 (2021)
Major depressive disorder (MDD) is a severe psychiatric condition with key symptoms of low mood and lack of motivation, joy, and pleasure. Recently, the acid sphingomyelinase (ASM)/ceramide system has been implicated in the pathogenesis of MDD. ASM i
Externí odkaz:
https://doaj.org/article/410c77b0b64b4afc83f69d33cedfb4a1
Autor:
Stefanie Zeitler, Fabian Schumacher, Juliana Monti, Daniela Anni, Debarpan Guhathakurta, Burkhard Kleuser, Kristina Friedland, Anna Fejtová, Johannes Kornhuber, Cosima Rhein
Publikováno v:
Cells, Vol 9, Iss 11, p 2502 (2020)
The acid sphingomyelinase (ASM)/ceramide system exhibits a crucial role in the pathology of major depressive disorder (MDD). ASM hydrolyzes the abundant membrane lipid sphingomyelin to ceramide that regulates the clustering of membrane proteins via m
Externí odkaz:
https://doaj.org/article/170c5c9bba314209a53ca85cf37b586b
Autor:
Iulia Zoicas, Fabian Schumacher, Burkhard Kleuser, Martin Reichel, Erich Gulbins, Anna Fejtova, Johannes Kornhuber, Cosima Rhein
Publikováno v:
Cells, Vol 9, Iss 5, p 1244 (2020)
Human and murine studies identified the lysosomal enzyme acid sphingomyelinase (ASM) as a target for antidepressant therapy and revealed its role in the pathophysiology of major depression. In this study, we generated a mouse model with overexpressio
Externí odkaz:
https://doaj.org/article/3e10dfc72350475c9cd25f481974f448
Autor:
Martin Reichel, Cosima Rhein, Lena M. Hofmann, Juliana Monti, Lukasz Japtok, Dominik Langgartner, Andrea M. Füchsl, Burkhard Kleuser, Erich Gulbins, Claus Hellerbrand, Stefan O. Reber, Johannes Kornhuber
Publikováno v:
Frontiers in Psychiatry, Vol 9 (2018)
Chronic psychosocial stress adversely affects human morbidity and is a risk factor for inflammatory disorders, liver diseases, obesity, metabolic syndrome, and major depressive disorder (MDD). In recent studies, we found an association of MDD with an
Externí odkaz:
https://doaj.org/article/d6e402f97aa34b3f8996ca7c6e7d78d3
Publikováno v:
International Journal of Molecular Sciences, Vol 16, Iss 6, Pp 13649-13652 (2015)
Loss-of-function mutations in the sphingomyelin phosphodiesterase 1 (SMPD1) gene are associated with decreased catalytic activity of acid sphingomyelinase (ASM) and are the cause of the autosomal recessive lysosomal storage disorder Niemann-Pick dise
Externí odkaz:
https://doaj.org/article/3924a8cf8217424aa28ec525786cf33e
Autor:
Cosima Rhein, Martin Reichel, Christiane Mühle, Andrea Rotter, Sibylle G. Schwab, Johannes Kornhuber
Publikováno v:
Cellular Physiology and Biochemistry, Vol 34, Iss 4, Pp 1385-1401 (2014)
Background: Acid sphingomyelinase (ASM) catalyses the hydrolysis of sphingomyelin into ceramide, which acts as a lipid messenger that regulates important cellular functions. Deregulated ASM activity has been reported for different common diseases, bu
Externí odkaz:
https://doaj.org/article/cb2937b152a84d679648f2a20246546e
Autor:
Martin Reichel, Tanja Richter-Schmidinger, Christiane Mühle, Cosima Rhein, Panagiotis Alexopoulos, Sibylle G. Schwab, Erich Gulbins, Johannes Kornhuber
Publikováno v:
Cellular Physiology and Biochemistry, Vol 34, Iss 1, Pp 82-91 (2014)
Background: Acid sphingomyelinase (ASM) is a key regulator of ceramide-dependent signalling pathways. Among others, activation of ASM can be induced by CD95 or cytokine signalling and by cellular stress resulting from inflammation or infection. Incre
Externí odkaz:
https://doaj.org/article/046a91a6853a4510bebcc8e1a45341bd