Troponin Structural Dynamics in the Native Cardiac Thin Filament Revealed by Cryo Electron Microscopy

Autor: Risi, Cristina M., Belknap, Betty, Atherton, Jennifer, Coscarella, Isabella Leite, White, Howard D., Bryant Chase, P., Pinto, Jose R., Galkin, Vitold E.

Publikováno v: In Journal of Molecular Biology 15 March 2024 436(6)

Metabolomic analysis of Cyrtopodium glutiniferum extract by UHPLC-MS/MS and in vitro antiproliferative and genotoxicity assessment

Autor: Araújo-Lima, Carlos Fernando, Paula da Silva Oliveira, Joana, Coscarella, Isabella Leite, Aiub, Claudia Alessandra Fortes, Felzenszwalb, Israel, Caprini Evaristo, Geisa Paulino, Macedo, Andrea Furtado

Publikováno v: In Journal of Ethnopharmacology 10 May 2020 253

Cardiac troponin T N-domain variant destabilizes the actin interface resulting in disturbed myofilament function

Autor: Landim-Vieira, Maicon, Ma, Weikang, Song, Taejeong, Rastegarpouyani, Hosna, Gong, Henry, Coscarella, Isabella Leite, Bogaards, Sylvia J. P., Conijn, Stefan P., Ottenheijm, Coen A. C., Hwang, Hyun S., Papadaki, Maria, Knollmann, Bjorn C., Sadayappan, Sakthivel, Irving, Thomas C., Galkin, Vitold E., Chase, P. Bryant, Pinto, Jose Renato

Publikováno v: Landim-Vieira, M, Ma, W, Song, T, Rastegarpouyani, H, Gong, H, Coscarella, I L, Bogaards, S J P, Conijn, S P, Ottenheijm, C A C, Hwang, H S, Papadaki, M, Knollmann, B C, Sadayappan, S, Irving, T C, Galkin, V E, Chase, P B & Pinto, J R 2023, ' Cardiac troponin T N-domain variant destabilizes the actin interface resulting in disturbed myofilament function ', Proceedings of the National Academy of Sciences of the United States of America, vol. 120, no. 23, e2221244120, pp. e2221244120 . https://doi.org/10.1073/pnas.2221244120
Proceedings of the National Academy of Sciences of the United States of America, 120(23). National Academy of Sciences

Missense variant Ile79Asn in human cardiac troponin T (cTnT-I79N) has been associated with hypertrophic cardiomyopathy and sudden cardiac arrest in juveniles. cTnT-I79N is located in the cTnT N-terminal (TnT1) loop region and is known for its patholo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::367b819020916bc8a9de4ed8cdd304a9
https://research.vumc.nl/en/publications/a2e6aa9f-38d9-415d-86ef-e83ade18a867

A missense variant in the Z-disc protein α-actinin 2: Evidence for a sarcomere protein at the nexus of thick and thin filament regulation

Autor: Rodriguez Garcia, Michelle C., Schmeckpeper, Jeffrey, Landim-Vieira, Maicon, Coscarella, Isabella Leite, Fang, Xuan, Ma, Weikang, Spran, Payton A., Kahmini, Aida Rahimi, Shoemaker, Moore B., Atkinson, James B., Kekenes-Huskey, Peter, Irving, Thomas, Chase, Prescott B., Knollmann, Björn C., Pinto, J. Renato

Publikováno v: Biophysical Journal; February 2024, Vol. 123 Issue: 3, Number 3 Supplement 1 p268a-269a, 2p

Cardiac troponin T N-domain variant destabilizes the actin interface resulting in disturbed myofilament function.

Autor: Landim-Vieira M; Department of Biomedical Sciences, Florida State University College of Medicine, Tallahassee, FL 32306., Ma W; Department of Biology, Illinois Institute of Technology, Chicago, IL 60616., Song T; Division of Cardiovascular Health and Disease, Department of Internal Medicine, University of Cincinnati College of Medicine, Cincinnati, OH 45267., Rastegarpouyani H; Department of Biological Science, Florida State University, Tallahassee, FL 32306.; Institude of Molecular Biophysics, Florida State University, Tallahassee, FL 32306., Gong H; Department of Biology, Illinois Institute of Technology, Chicago, IL 60616., Coscarella IL; Department of Biomedical Sciences, Florida State University College of Medicine, Tallahassee, FL 32306., Bogaards SJP; Department of Physiology, Amsterdam University Medical Center, Amsterdam, De Boelelaan 1108, 1081 HZ Amsterdam, The Netherlands., Conijn SP; Department of Physiology, Amsterdam University Medical Center, Amsterdam, De Boelelaan 1108, 1081 HZ Amsterdam, The Netherlands., Ottenheijm CAC; Department of Physiology, Amsterdam University Medical Center, Amsterdam, De Boelelaan 1108, 1081 HZ Amsterdam, The Netherlands., Hwang HS; Department of Nutrition and Integrative Physiology, Florida State University, Tallahassee, FL 32306., Papadaki M; Department of Cell and Molecular Physiology, Loyola University Chicago Stritch School of Medicine, Chicago, IL 60153., Knollmann BC; Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37232., Sadayappan S; Division of Cardiovascular Health and Disease, Department of Internal Medicine, University of Cincinnati College of Medicine, Cincinnati, OH 45267., Irving TC; Department of Biology, Illinois Institute of Technology, Chicago, IL 60616., Galkin VE; Department of Physiological Sciences, Eastern Virginia Medical School, Norfolk, VA 23507., Chase PB; Department of Biological Science, Florida State University, Tallahassee, FL 32306., Pinto JR; Department of Biomedical Sciences, Florida State University College of Medicine, Tallahassee, FL 32306.

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2023 Jun 06; Vol. 120 (23), pp. e2221244120. Date of Electronic Publication: 2023 May 30.