Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Cory Schwartz"'
Autor:
Adithya Ramesh, Varun Trivedi, Sangcheon Lee, Aida Tafrishi, Cory Schwartz, Amirsadra Mohseni, Mengwan Li, Stefano Lonardi, Ian Wheeldon
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-11 (2023)
Abstract High throughput CRISPR screens are revolutionizing the way scientists unravel the genetic underpinnings of engineered and evolved phenotypes. One of the critical challenges in accurately assessing screening outcomes is accounting for the var
Externí odkaz:
https://doaj.org/article/4194a4ba4e654adda3d79a7ea036be11
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-10 (2022)
The successful use of CRISPR-based mutagenesis in non-conventional microorganisms requires high activity sgRNAs. Here, the authors present DeepGuide, a neural network-based architecture, that learns from genome-wide CRISPR activity profiles to accura
Externí odkaz:
https://doaj.org/article/a11c8ef126f549f784c9758190315fda
Publikováno v:
Synthetic and Systems Biotechnology, Vol 2, Iss 3, Pp 198-207 (2017)
Microbial production of chemicals and proteins from biomass-derived and waste sugar streams is a rapidly growing area of research and development. While the model yeast Saccharomyces cerevisiae is an excellent host for the conversion of glucose to et
Externí odkaz:
https://doaj.org/article/2b0e3310e682404d9771548f261c2835
Publikováno v:
Biotechnology for Biofuels, Vol 10, Iss 1, Pp 1-14 (2017)
Abstract Background The thermotolerant yeast Kluyveromyces marxianus shows promise as an industrial host for the biochemical production of fuels and chemicals. Wild-type strains are known to ferment high titers of ethanol and can effectively convert
Externí odkaz:
https://doaj.org/article/ea7b736d6a7c49ec934a997cf4118fba
Publikováno v:
Metabolic Engineering Communications, Vol 8, Iss , Pp - (2019)
In metabolic engineering, most available pathway engineering strategies aim to control enzyme expression by making changes at the transcriptional level with an underlying assumption that translation and functional expression follow suit. In this work
Externí odkaz:
https://doaj.org/article/d4879a017bab4c60b9d161b7d60c57c1
Publikováno v:
Bio-Protocol, Vol 8, Iss 6 (2018)
The discovery of the CRISPR-Cas9 system from Streptococcus pyogenes has allowed the development of genome engineering tools in a variety of organisms. A frequent limitation in CRISPR-Cas9 function is adequate expression levels of sgRNA. This protocol
Externí odkaz:
https://doaj.org/article/c744c8f31ea046ff896e4bcf6e8df332
Publikováno v:
Frontiers in Microbiology, Vol 8 (2017)
Carotenoids are a class of molecules with commercial value as food and feed additives with nutraceutical properties. Shifting carotenoid synthesis from petrochemical-based precursors to bioproduction from sugars and other biorenewable carbon sources
Externí odkaz:
https://doaj.org/article/2fc34e9bce9f4be9b9277db529f11d95
Publikováno v:
Biotechnology and Bioengineering. 119:3623-3631
Yarrowia lipolytica is a metabolic engineering host of growing industrial interest due to its ability to metabolize hydrocarbons, fatty acids, glycerol, and other renewable carbon sources. This dimorphic yeast undergoes a stress-induced transition to
Autor:
Adithya Ramesh, Varun Trivedi, Cory Schwartz, Aida Tafrishi, Amirsadra Mohseni, Mengwan Li, Stefano Lonardi, Ian Wheeldon
High throughput CRISPR screens are revolutionizing the way scientists unravel the genetic underpinnings of novel and evolved phenotypes. One of the critical challenges in accurately assessing screening outcomes is accounting for the variability in sg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e6aad74cf2732e962ea53f46b51b3a5e
https://doi.org/10.1101/2022.07.12.499789
https://doi.org/10.1101/2022.07.12.499789
Autor:
Joshua, Misa, Cory, Schwartz
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 2307
Recent developments in RNA-guided nuclease technologies have advanced the engineering of a wide range of organisms, including the nonconventional yeast Yarrowia lipolytica. Y. lipolytica has been the focus of a range of synthetic biology and metaboli