Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Cory Giesbrecht"'
Publikováno v:
Molecular Therapy. 15:713-720
Using a new controlled mixing process, highly transfection-competent polyplexes were formed and subsequently encapsulated within a lipid bilayer. The resulting "pre-condensed stable plasmid lipid particles" (pSPLPs) have small size (104+/-3 nm) and l
Autor:
Lloyd Jeffs, Ellen Grace Ambegia, Ian MacLachlan, Cory Giesbrecht, Lorne R. Palmer, Shannon Ewanick
Publikováno v:
Pharmaceutical Research. 22:362-372
A fully scalable and extrusion-free method was developed to prepare rapidly and reproducibly stabilized plasmid lipid particles (SPLP) for nonviral, systemic gene therapy. Liposomes encapsulating plasmid DNA were formed instantaneously by mixing lipi
Autor:
Cory Giesbrecht, Kitty P. Y. Chan, Kevin McClintock, Lloyd Jeffs, Ian MacLachlan, James Heyes, Amy C.H. Lee, Lorne R. Palmer
Publikováno v:
Molecular Therapy. 9:S257
Systemic delivery of DNA to disease sites has been previously demonstrated with Stable Plasmid Lipid Particles (SPLP) containing a single plasmid molecule encapsulated with a lipid bilayer stabilized by poly(ethylene glycol) (PEG) lipids. This techno