Zobrazeno 1 - 10
of 230
pro vyhledávání: '"Cory Abate-Shen"'
Autor:
Hubert Pakula, Mohamed Omar, Ryan Carelli, Filippo Pederzoli, Giuseppe Nicolò Fanelli, Tania Pannellini, Fabio Socciarelli, Lucie Van Emmenis, Silvia Rodrigues, Caroline Fidalgo-Ribeiro, Pier Vitale Nuzzo, Nicholas J. Brady, Wikum Dinalankara, Madhavi Jere, Itzel Valencia, Christopher Saladino, Jason Stone, Caitlin Unkenholz, Richard Garner, Mohammad K. Alexanderani, Francesca Khani, Francisca Nunes de Almeida, Cory Abate-Shen, Matthew B. Greenblatt, David S. Rickman, Christopher E. Barbieri, Brian D. Robinson, Luigi Marchionni, Massimo Loda
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-21 (2024)
Abstract In the complex tumor microenvironment (TME), mesenchymal cells are key players, yet their specific roles in prostate cancer (PCa) progression remain to be fully deciphered. This study employs single-cell RNA sequencing to delineate molecular
Externí odkaz:
https://doaj.org/article/f358a6f85a6c4b2189686dbb0cfa358f
Autor:
Casey Ager, Aleksandar Obradovic, Juan M. Arriaga, Matthew G. Chaimowitz, Cory Abate-Shen, Andrea Califano, Charles G. Drake
Publikováno v:
Journal of Clinical and Translational Science, Vol 6, Pp 60-60 (2022)
OBJECTIVES/GOALS: Few preclinical models exist to study how tumors transition from prolonged stable disease ('equilibrium') to progressive disease ('escape'). We characterized a new murine tumor model the exhibits such behavior, and sought to identif
Externí odkaz:
https://doaj.org/article/9256ba0e6d9a4e3cbfcdadc71564336b
Autor:
Alvaro Aytes, Arianna Giacobbe, Antonina Mitrofanova, Katia Ruggero, Joanna Cyrta, Juan Arriaga, Luis Palomero, Sonia Farran-Matas, Mark A. Rubin, Michael M. Shen, Andrea Califano, Cory Abate-Shen
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
Identifying cell intrinsic mechanisms promoting metastasis are necessary to develop new cancer therapeutics. Here they do cross-species computational analysis and identify nuclear receptor binding SET domain Protein 2 (NSD2) as a driver of prostate c
Externí odkaz:
https://doaj.org/article/64e525ee05e54b2cbb33506e939b3948
Autor:
Andrea Califano, Casey Ager, Aleksander Obradovic, Juan Arriaga, Matthew Chaimowitz, Cory Abate-Shen
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 8, Iss Suppl 3 (2020)
Externí odkaz:
https://doaj.org/article/735dc57333b84c2fbf89fb8ef7e4b1af
Autor:
Clémentine Le Magnen, Renu K. Virk, Aditya Dutta, Jaime Yeji Kim, Sukanya Panja, Zoila A. Lopez-Bujanda, Andrea Califano, Charles G. Drake, Antonina Mitrofanova, Cory Abate-Shen
Publikováno v:
Disease Models & Mechanisms, Vol 11, Iss 11 (2018)
Although it is known that inflammation plays a critical role in prostate tumorigenesis, the underlying processes are not well understood. Based on analysis of genetically engineered mouse models combined with correlative analysis of expression profil
Externí odkaz:
https://doaj.org/article/1101e9bdeeee454f88d94a0d8d3d0928
Autor:
Antonina Mitrofanova, Alvaro Aytes, Min Zou, Michael M. Shen, Cory Abate-Shen, Andrea Califano
Publikováno v:
Cell Reports, Vol 12, Iss 12, Pp 2060-2071 (2015)
Although genetically engineered mouse (GEM) models are often used to evaluate cancer therapies, extrapolation of such preclinical data to human cancer can be challenging. Here, we introduce an approach that uses drug perturbation data from GEM models
Externí odkaz:
https://doaj.org/article/388ce397f43d417a999e1701ccb26442
Autor:
Jingqiang Wang, Cory Abate-Shen
Publikováno v:
PLoS ONE, Vol 7, Iss 5, p e37647 (2012)
Although the significance of lysine modifications of core histones for regulating gene expression is widely appreciated, the mechanisms by which these modifications are incorporated at specific regulatory elements during cellular differentiation rema
Externí odkaz:
https://doaj.org/article/120039af380740d0b6913aa359f5efce
Autor:
Joseph H Jeong, Zhenxiong Wang, Alexander S Guimaraes, Xuesong Ouyang, Jose L Figueiredo, Zhihu Ding, Shan Jiang, Isil Guney, Gyeong Hoon Kang, Eyoung Shin, William C Hahn, Massimo F Loda, Cory Abate-Shen, Ralph Weissleder, Lynda Chin
Publikováno v:
PLoS ONE, Vol 3, Iss 12, p e3949 (2008)
Prostate cancer is the second leading cause of cancer-related deaths in men. Activation of MAP kinase signaling pathway has been implicated in advanced and androgen-independent prostate cancers, although formal genetic proof has been lacking. In the
Externí odkaz:
https://doaj.org/article/84806d4b9dcd416ba7bed46bdcd557a5
Autor:
Cory Abate-Shen, Andrea Califano, Michael M. Shen, Mark A. Rubin, Mariano J. Alvarez, Eva Corey, Luca Zanella, Timur Mukhammadov, Stephanie N. Afari, Jaime Y. Kim, Sergey Pampou, Ronald Realubit, Charles Karan, Chee Wai Chua, Antonina Mitrofanova, Simone de Brot, Antonio Rodriguez-Calero, Maho Shibata, Florencia Picech, Eugene F. Douglass, Min Zou, Francisca Nunes de Almeida, Juan Martín Arriaga, Alessandro Vasciaveo
Index of Supplementary Data
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::400192d080ba228dd2401397762ff34b
https://doi.org/10.1158/2159-8290.22541971.v1
https://doi.org/10.1158/2159-8290.22541971.v1
Autor:
Cory Abate-Shen, Andrea Califano, Michael M. Shen, Mark A. Rubin, Mariano J. Alvarez, Eva Corey, Luca Zanella, Timur Mukhammadov, Stephanie N. Afari, Jaime Y. Kim, Sergey Pampou, Ronald Realubit, Charles Karan, Chee Wai Chua, Antonina Mitrofanova, Simone de Brot, Antonio Rodriguez-Calero, Maho Shibata, Florencia Picech, Eugene F. Douglass, Min Zou, Francisca Nunes de Almeida, Juan Martín Arriaga, Alessandro Vasciaveo
Supplementary Table 3: Transcriptomic analyses of the human patient samples A. TCGA Interactome B. SU2C Interactome C. Protein activity TCGA D. Protein Activity SU2C
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50152ab5715db26bd60d40e0922dd5e7
https://doi.org/10.1158/2159-8290.22541959
https://doi.org/10.1158/2159-8290.22541959