Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Cornelia Schwerdel"'
Autor:
Patrik Simmler, Eleonora I Ioannidi, Tamara Mengis, Kim Fabiano Marquart, Simran Asawa, Kjong Van-Lehmann, Andre Kahles, Tinu Thomas, Cornelia Schwerdel, Nicola Aceto, Gunnar Rätsch, Markus Stoffel, Gerald Schwank
Publikováno v:
eLife, Vol 12 (2023)
The splicing factor SF3B1 is recurrently mutated in various tumors, including pancreatic ductal adenocarcinoma (PDAC). The impact of the hotspot mutation SF3B1K700E on the PDAC pathogenesis, however, remains elusive. Here, we demonstrate that Sf3b1K7
Externí odkaz:
https://doaj.org/article/60ac28afd80545779ac04224dc960954
Autor:
Claire de Groot, Amalia Floriou-Servou, Yuan-Chen Tsai, Simon Früh, Manuela Kohler, Georgia Parkin, Cornelia Schwerdel, Giovanna Bosshard, Kai Kaila, Jean-Marc Fritschy, Shiva K Tyagarajan
Publikováno v:
PLoS Genetics, Vol 13, Iss 10, p e1007073 (2017)
In developing brain neuronal migration, dendrite outgrowth and dendritic spine outgrowth are controlled by Cdc42, a small GTPase of the Rho family, and its activators. Cdc42 function in promoting actin polymerization is crucial for glutamatergic syna
Externí odkaz:
https://doaj.org/article/7cb2b632fcce41a0b646288801f9b475
Autor:
Cornelia Schwerdel, Lena Rubi, Leonardo Cristiá-Lara, Ida Luisa Boccalaro, Jean-Marc Fritschy
Publikováno v:
European Journal of Neuroscience. 52:3353-3374
Lack of dopamine (DA) in the striatum and the consequential dysregulation of thalamocortical circuits are major causes of motor impairments in Parkinson's disease. The striatum receives multiple cortical and subcortical afferents. Its role in movemen
Autor:
Jean-Marc Fritschy, Leonardo Cristiá-Lara, Lena Rubi, Ida Luisa Boccalaro, Cornelia Schwerdel
Publikováno v:
Journal of Comparative Neurology. 527:2030-2046
The striatum is the main input nucleus of the basal ganglia, mediating motor and cognitive functions. Striatal projection neurons are GABAergic medium spiny neurons (MSN), expressing either the dopamine receptor type 1 (D1 -R MSN) and forming the dir
Autor:
Ida Luisa, Boccalaro, Leonardo, Cristiá-Lara, Cornelia, Schwerdel, Jean-Marc, Fritschy, Lena, Rubi
Publikováno v:
The Journal of comparative neurology. 527(12)
The striatum is the main input nucleus of the basal ganglia, mediating motor and cognitive functions. Striatal projection neurons are GABAergic medium spiny neurons (MSN), expressing either the dopamine receptor type 1 (D
Autor:
Amalia Floriou-Servou, Manuela Kohler, Giovanna Bosshard, Georgia M. Parkin, Claire de Groot, Simon Frueh, Shiva K. Tyagarajan, Kai Kaila, Yuan-Chen Tsai, Cornelia Schwerdel, Jean-Marc Fritschy
Publikováno v:
PLoS Genetics, Vol 13, Iss 10, p e1007073 (2017)
PLoS Genetics
PLoS Genetics
In developing brain neuronal migration, dendrite outgrowth and dendritic spine outgrowth are controlled by Cdc42, a small GTPase of the Rho family, and its activators. Cdc42 function in promoting actin polymerization is crucial for glutamatergic syna
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f078612a7aeef479b62806ac5e374683
https://doi.org/10.1101/197905
https://doi.org/10.1101/197905
Autor:
Wolfgang Härtig, Tamara Weber, Jean-Marc Fritschy, Irene Knuesel, Sandra Pfister, Cornelia Schwerdel, Rebecca Elsaesser
Publikováno v:
Journal of Comparative Neurology. 523:406-430
The olfactory epithelium (OE) of mice deficient in cystic fibrosis transmembrane conductance regulator (CFTR) exhibits ion transport deficiencies reported in human CF airways, as well as progressive neuronal loss, suggesting defects in olfactory neur
Autor:
Dietmar Benke, Benjamin K. Yee, Laetitia Gabernet, Joram Feldon, Irene Knuesel, Ela Balic, Cornelia Schwerdel, Hanns Möhler, Thomas Grampp, Philipp Singer, Detlev Boison
Publikováno v:
The Journal of Neuroscience. 26:3169-3181
The NMDA receptor is thought to play a central role in some forms of neuronal plasticity, including the induction of long-term potentiation. NMDA receptor hypofunction can result in mnemonic impairment and has been implicated in the cognitive symptom
Autor:
Daniela Alberati, Laetitia Gabernet, Horst Bluethmann, Michèle Lentz, Kaspar E. Vogt, Cornelia Schwerdel, Hanns Möhler, Meike Pauly-Evers, Detlev Boison
Publikováno v:
Neuroscience Letters. 373:79-84
The occupation of the glycine binding-site is a prerequisite for NMDA receptor activation by glutamate. To analyze the regulation of NMDA receptor function by the glycine transporter 1 (GlyT1), we generated heterozygous constitutive GlyT1 knockout mi