Zobrazeno 1 - 10
of 326
pro vyhledávání: '"Cormac T, Taylor"'
Autor:
Zachary J. Rogers, Thibault Colombani, Saad Khan, Khushbu Bhatt, Alexandra Nukovic, Guanyu Zhou, Benjamin M. Woolston, Cormac T. Taylor, Daniele M. Gilkes, Nikolai Slavov, Sidi A. Bencherif
Publikováno v:
Advanced Science, Vol 11, Iss 30, Pp n/a-n/a (2024)
Abstract In oxygen (O2)‐controlled cell culture, an indispensable tool in biological research, it is presumed that the incubator setpoint equals the O2 tension experienced by cells (i.e., pericellular O2). However, it is discovered that physioxic (
Externí odkaz:
https://doaj.org/article/1068060eb74c48a59b7780c76e69d254
Autor:
Raphael R. Fagundes, Gabriela Bravo-Ruiseco, Shixian Hu, Sarah J. Kierans, Rinse K. Weersma, Cormac T. Taylor, Gerard Dijkstra, Hermie J. M. Harmsen, Klaas Nico Faber
Publikováno v:
Frontiers in Microbiology, Vol 14 (2023)
IntroductionIntestinal epithelial cells produce interleukin-18 (IL-18), a key factor in promoting epithelial barrier integrity. Here, we analyzed the potential role of gut bacteria and the hypoxia-inducible factor 1α (HIF1α) pathway in regulating m
Externí odkaz:
https://doaj.org/article/5f37fa2f42fd405ca3fe8ff2670a47dc
Autor:
Jennifer M. Noto, M. Blanca Piazuelo, Judith Romero-Gallo, Alberto G. Delgado, Giovanni Suarez, Konstantina Akritidou, Miguel Girod Hoffman, Juan Carlos Roa, Cormac T. Taylor, Richard M. Peek
Publikováno v:
Gut Microbes, Vol 15, Iss 2 (2023)
ABSTRACTHelicobacter pylori-induced inflammation is the strongest known risk factor for gastric adenocarcinoma. Hypoxia-inducible factor-1 (HIF-1α) is a key transcriptional regulator of immunity and carcinogenesis. To examine the role of this mediat
Externí odkaz:
https://doaj.org/article/5ca1554c76e54c8382886b3806ff21b3
Autor:
Kilian B. Kennel, Julius Burmeister, Praveen Radhakrishnan, Nathalia A. Giese, Thomas Giese, Martin Salfenmoser, Jasper M. Gebhardt, Moritz J. Strowitzki, Cormac T. Taylor, Ben Wielockx, Martin Schneider, Jonathan M. Harnoss
Publikováno v:
JCI Insight, Vol 7, Iss 22 (2022)
Colitis-associated colorectal cancer (CAC) is a severe complication of inflammatory bowel disease (IBD). HIF-prolyl hydroxylases (PHD1, PHD2, and PHD3) control cellular adaptation to hypoxia and are considered promising therapeutic targets in IBD. Ho
Externí odkaz:
https://doaj.org/article/a20876b916204a5480cf7df3a59468fb
Autor:
Raphael R. Fagundes, Arno R. Bourgonje, Shixian Hu, Ruggero Barbieri, Bernadien H. Jansen, Nienke Sinnema, Tjasso Blokzijl, Cormac T. Taylor, Rinse K. Weersma, Klaas Nico Faber, Gerard Dijkstra
Publikováno v:
Frontiers in Physiology, Vol 13 (2022)
Background and Aims: Iron deficiency (ID) is a frequent extra-intestinal manifestation in patients with Inflammatory Bowel Disease (IBD), who often do not respond to iron supplementation. Iron is a cofactor for hydroxylases that suppress the hypoxia-
Externí odkaz:
https://doaj.org/article/e4a7a598a9e746c48a15192845949bc6
Autor:
Sophie J. Crinion, Jana Kleinerova, Brian Kent, Geraldine Nolan, Cormac T. Taylor, Silke Ryan, Walter T. McNicholas
Publikováno v:
ERJ Open Research, Vol 7, Iss 3 (2021)
Background Obstructive sleep apnoea (OSA) is strongly associated with systemic hypertension, but there are limited data on the relationship with blood pressure (BP) in normotensive subjects. Here, we examined the relationship of OSA with nocturnal BP
Externí odkaz:
https://doaj.org/article/36b68107a5004d3ab3c67fe1020f54c9
Autor:
Moritz J. Strowitzki, Gwendolyn Kimmer, Julian Wehrmann, Alina S. Ritter, Praveen Radhakrishnan, Vanessa M. Opitz, Christopher Tuffs, Marvin Biller, Julia Kugler, Ulrich Keppler, Jonathan M. Harnoss, Johannes Klose, Thomas Schmidt, Alfonso Blanco, Cormac T. Taylor, Martin Schneider
Publikováno v:
JCI Insight, Vol 6, Iss 8 (2021)
Anastomotic leakage (AL) accounts for a major part of in-house mortality in patients undergoing colorectal surgery. Local ischemia and abdominal sepsis are common risk factors contributing to AL and are characterized by upregulation of the hypoxia-in
Externí odkaz:
https://doaj.org/article/76b029c8965e460eac6d2501514203de
Publikováno v:
American Journal of Physiology-Cell Physiology. 323:C866-C878
The healthy mammalian intestine is lined by a single layer of epithelial cells. These cells provide a selectively permeable barrier to luminal contents and normally do so in an efficient and effective manner. Barrier function in the healthy mucosa is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f5bae777076ec87fed9fe643bfa29cb
https://doi.org/10.1152/ajpcell.00227.2022
https://doi.org/10.1152/ajpcell.00227.2022
Publikováno v:
Cells, Vol 10, Iss 9, p 2340 (2021)
Hypoxia and inflammation are frequently co-incidental features of the tissue microenvironment in a wide range of inflammatory diseases. While the impact of hypoxia on inflammatory pathways in immune cells has been well characterized, less is known ab
Externí odkaz:
https://doaj.org/article/bfdc95fe18b947c587e0315d28d64f73
Autor:
Mario C. Manresa, Cormac T. Taylor
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 3, Iss 3, Pp 303-315 (2017)
Human health is dependent on the ability of the body to extract nutrients, fluids, and oxygen from the external environment while at the same time maintaining a state of internal sterility. Therefore, the cell layers that cover the surface areas of t
Externí odkaz:
https://doaj.org/article/a21cd237032a42898676917038349492