Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Corey N Miller"'
Autor:
Kristen L Wells, Corey N Miller, Andreas R Gschwind, Wu Wei, Jonah D Phipps, Mark S Anderson, Lars M Steinmetz
Publikováno v:
eLife, Vol 9 (2020)
Medullary thymic epithelial cells (mTECs) play a critical role in central immune tolerance by mediating negative selection of autoreactive T cells through the collective expression of the peripheral self-antigen compartment, including tissue-specific
Externí odkaz:
https://doaj.org/article/7e6e9a65e4af4c6ea418368160781fcd
Autor:
D Thomas Rutkowski, Stacey M Arnold, Corey N Miller, Jun Wu, Jack Li, Kathryn M Gunnison, Kazutoshi Mori, Amir A Sadighi Akha, David Raden, Randal J Kaufman
Publikováno v:
PLoS Biology, Vol 4, Iss 11, p e374 (2006)
The accumulation of unfolded proteins in the endoplasmic reticulum (ER) activates a signaling cascade known as the unfolded protein response (UPR). Although activation of the UPR is well described, there is little sense of how the response, which ini
Externí odkaz:
https://doaj.org/article/a026c3ed14ba4c9a93f5af077eeaf9c4
Autor:
Jesse D. Deere, David Merriam, Kawthar Machmach Leggat, Wen-Lan William Chang, Gema Méndez-Lagares, Hung Kieu, Joseph Dutra, Justin Fontaine, Wenze Lu, Ning Chin, Connie Chen, Bryant Chi-Thien Tran, Jessica Salinas, Corey N. Miller, Steven G. Deeks, Jeffrey D. Lifson, Kathleen Engelman, Diogo Magnani, Keith Reimann, Mario Stevenson, Dennis J. Hartigan-O’Connor
Publikováno v:
bioRxiv
SUMMARY PARAGRAPHTreatment of people with HIV (PWH) with antiretroviral therapy (ART) results in sustained suppression of viremia, but HIV persists indefinitely as integrated provirus in CD4-expressing cells. Intact persistent provirus, the “reboun
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ddc3eb1ebcc555093c74766e6dc4e3fd
https://europepmc.org/articles/PMC10187202/
https://europepmc.org/articles/PMC10187202/
Autor:
Rebecca S. LaRue, Louisa E. Sjaastad, Mark S. Anderson, Calvin B. Williams, Praful Aggarwal, Maria-Luisa Alegre, Ulrich Broeckel, Shawn A. Mahmud, Irina Proekt, Dimitre R. Simeonov, Jason B. Williams, Michael A. Farrar, Weishan Huang, Jonathan C. Jeschke, Corey N. Miller, Roland Ruscher, David L. Owen, Christine Henzler, Justin A. Spanier, Can Hekim, Avery August, Alexander Marson, Ye Zheng
Publikováno v:
Nature immunology
The developmental programs that generate a broad repertoire of regulatory T cells (Treg cells) able to respond to both self antigens and non-self antigens remain unclear. Here we found that mature Treg cells were generated through two distinct develo
Autor:
Lauren Byrnes, Julie B. Sneddon, James M. Gardner, Mark S. Anderson, Corey N. Miller, Jessica Chavez, Joe Germino, Trevor D. Burt, Nathan T. Cramer, Audrey Parent, Vasilis Ntranos, Jhoanne L. Bautista, Chun Jimmie Ye, David I. Berrios
Publikováno v:
Nature Communications, vol 12, iss 1
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Nature Communications
Nature communications, vol 12, iss 1
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Nature Communications
Nature communications, vol 12, iss 1
The thymus’ key function in the immune system is to provide the necessary environment for the development of diverse and self-tolerant T lymphocytes. While recent evidence suggests that the thymic stroma is comprised of more functionally distinct s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f56b0f8b181ef421bf2c0346a05f2d6
https://escholarship.org/uc/item/6hz0m32x
https://escholarship.org/uc/item/6hz0m32x
Autor:
Lars M. Steinmetz, Wu Wei, Mark S. Anderson, Andreas R Gschwind, Kristen L. Wells, Corey N. Miller, Jonah D Phipps
Medullary thymic epithelial cells (mTECs) play a critical role in central immune tolerance by mediating negative selection of autoreactive T cells through the collective expression of the peripheral self-antigen compartment, including tissue-specific
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::df8ebee3b26f4433b3d6e4ee64494b34
https://doi.org/10.1101/2020.06.19.160424
https://doi.org/10.1101/2020.06.19.160424
Autor:
Wu Wei, Kristen L. Wells, Jonah D Phipps, Andreas R Gschwind, Corey N. Miller, Lars M. Steinmetz, Mark S. Anderson
Publikováno v:
eLife
eLife, Vol 9 (2020)
eLife, Vol 9 (2020)
Medullary thymic epithelial cells (mTECs) play a critical role in central immune tolerance by mediating negative selection of autoreactive T cells through the collective expression of the peripheral self-antigen compartment, including tissue-specific
Autor:
Mark S. Anderson, Richard M. Locksley, Lars M. Steinmetz, Corey N. Miller, Joshua L. Pollack, Wint Lwin, Imran S. Khan, Todd C. Metzger, Bruno Kyewski, Aparna R. Rajpurkar, David J. Erle, Kristin Rattay, Irina Proekt, Adam Fries, Haiguang Wang, Kristen L. Wells, Jakob von Moltke, Kristin A. Hogquist, Audrey Parent, Eric J. Wigton
Publikováno v:
Nature
The thymus is responsible for generating a diverse yet self-tolerant pool of T cells1. Although the thymic medulla consists mostly of developing and mature AIRE+ epithelial cells, recent evidence has suggested that there is far greater heterogeneity
Publikováno v:
Current Opinion in Immunology. 49:71-78
AIRE is a well-established master regulator of central tolerance. It plays an essential role in driving expression of tissue-specific antigens in the thymus and shaping the development of positively selected T-cells. Humans and mice with compromised