Zobrazeno 1 - 10
of 105
pro vyhledávání: '"Copy number loss"'
Publikováno v:
BMC Genomics, Vol 23, Iss 1, Pp 1-9 (2022)
Abstract Background The broad application of high-resolution chromosome detection technology in prenatal diagnosis has identified copy number loss (CNL) involving autosomal dominant (AD) genes in certain fetuses. Exon sequencing of fetuses exhibiting
Externí odkaz:
https://doaj.org/article/8b1f5899d20841f49e833f5362c5d9d0
Autor:
Xiaoxi Dong, Tiantian Zheng, Minhua Zhang, Chao Dai, Lili Wang, Lei Wang, Ruipeng Zhang, Yuan Long, Danyi Wen, Feng Xie, Yue Zhang, Yong Huang, Jianguo Dong, Huan Liu, Pan Du, Bonnie L. King, Winston Tan, Shidong Jia, Chris X. Lu, Manish Kohli, Haitao Wang, Jianjun Yu
Publikováno v:
Frontiers in Oncology, Vol 11 (2021)
Current liquid biopsy assays lack sufficient sensitivity to detect copy number loss, which limits the interrogation of critical tumor suppressor gene deletions during cancer progression and treatment. Here we describe a liquid biopsy assay with impro
Externí odkaz:
https://doaj.org/article/8d43e9fdf19046549c4e88294af7337c
Publikováno v:
Cells, Vol 11, Iss 11, p 1762 (2022)
Autophagy allows cells to temporarily tolerate energy stress by replenishing critical metabolites through self-digestion, thereby attenuating the cytotoxic effects of anticancer drugs that target tumor metabolism. Autophagy defects could therefore ma
Externí odkaz:
https://doaj.org/article/219bfd315aa044868d1679dbef9f65db
Akademický článek
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Publikováno v:
Cells; Volume 11; Issue 11; Pages: 1762
Autophagy allows cells to temporarily tolerate energy stress by replenishing critical metabolites through self-digestion, thereby attenuating the cytotoxic effects of anticancer drugs that target tumor metabolism. Autophagy defects could therefore ma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c420ec720161ebb58be42d88ffcc77e
Akademický článek
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Autor:
Xianyong Lan, Yongzhen Huang, Jie Cheng, Yuhan Chen, George E. Liu, Hong Chen, Sayed Haidar Abbas Raza, Long Yang, Mei Liu, Chuzhao Lei
Publikováno v:
Animal Biotechnology. :1-6
Goat is an important sector for meat and dairy products. Diacylglycerol O-acyltransferase 1 (DGAT1), which is a key gene in milk production, has been recently detected to overlap with a novel copy number variation (CNV) in goats. CNVs could be geneti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a640653ebb9d8419833205031f7d3ad7
https://doi.org/10.1080/10495398.2021.2007118
https://doi.org/10.1080/10495398.2021.2007118
Autor:
J. Christopher Love, Joseph R. Brady, Andrew J. Maloney, Amos E. Lu, Kerry R. Love, Richard D. Braatz, Neil C. Dalvie
Publikováno v:
Biotechnology and Bioengineering. 118:1832-1839
Development of continuous biopharmaceutical manufacturing processes is an area of active research. This study considers the long-term transgene copy number stability of Pichia pastoris in continuous bioreactors. We propose a model of copy number loss
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8642552ee070ad18be12a3b3f32f638e
https://doi.org/10.1002/bit.27698
https://doi.org/10.1002/bit.27698
Akademický článek
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Autor:
Xiaojing Zhu, Yong Zhang, Jianlong Liao, Yun Xiao, Aimin Xie, Xin Liang, Xiaobo Hou, Peng Cheng, Lin Pang, Xia Li, Shiwei Zhu, Fei Quan
Publikováno v:
International Journal of Cancer. 147:3139-3151
The evolutionary dynamics of human cancers has been investigated popularly and several bifurcated paths in cancer evolutionary trajectories are revealed to be with differential outcomes and phenotypes. However, whether such bifurcated paths exist in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5b658a80d795ba7d1af929d29dcf606
https://doi.org/10.1002/ijc.33276
https://doi.org/10.1002/ijc.33276