Zobrazeno 1 - 10
of 556
pro vyhledávání: '"Copy number aberrations"'
Autor:
Matthew A. Myers, Brian J. Arnold, Vineet Bansal, Metin Balaban, Katelyn M. Mullen, Simone Zaccaria, Benjamin J. Raphael
Publikováno v:
Genome Biology, Vol 25, Iss 1, Pp 1-28 (2024)
Abstract Bulk DNA sequencing of multiple samples from the same tumor is becoming common, yet most methods to infer copy-number aberrations (CNAs) from this data analyze individual samples independently. We introduce HATCHet2, an algorithm to identify
Externí odkaz:
https://doaj.org/article/ef907d97ffe74c0c88e8cee6b183c84e
Publikováno v:
Algorithms for Molecular Biology, Vol 19, Iss 1, Pp 1-15 (2024)
Abstract Copy number aberrations (CNAs) are ubiquitous in many types of cancer. Inferring CNAs from cancer genomic data could help shed light on the initiation, progression, and potential treatment of cancer. While such data have traditionally been a
Externí odkaz:
https://doaj.org/article/1fe16961b9f745d39de888c1985282b8
Autor:
Maren Høland, Kaja C.G. Berg, Ina A. Eilertsen, Bodil Bjerkehagen, Matthias Kolberg, Kjetil Boye, Ole Christian Lingjærde, Tormod K. Guren, Nils Mandahl, Eva van den Berg, Emanuela Palmerini, Sigbjørn Smeland, Piero Picci, Fredrik Mertens, Anita Sveen, Ragnhild A. Lothe
Publikováno v:
EBioMedicine, Vol 97, Iss , Pp 104829- (2023)
Summary: Background: Malignant peripheral nerve sheath tumour (MPNST) is an aggressive orphan disease commonly affecting adolescents or young adults. Current knowledge of molecular tumour biology has been insufficient for development of rational trea
Externí odkaz:
https://doaj.org/article/120a8ea2f5d04915b737b8e0d970bebb
Autor:
Carolin M Sauer, Katrin Heider, Jelena Belic, Samantha E Boyle, James A Hall, Dominique‐Laurent Couturier, Angela An, Aadhitthya Vijayaraghavan, Marika AV Reinius, Karen Hosking, Maria Vias, Nitzan Rosenfeld, James D Brenton
Publikováno v:
EMBO Molecular Medicine, Vol 14, Iss 8, Pp 1-12 (2022)
Abstract Whole‐genome sequencing (WGS) of circulating tumour DNA (ctDNA) is now a clinically important biomarker for predicting therapy response, disease burden and disease progression. However, the translation of ctDNA monitoring into vital precli
Externí odkaz:
https://doaj.org/article/d7402f932e024ca29f08a4f9f317194b
Akademický článek
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Akademický článek
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Akademický článek
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Autor:
Gang Peng, Hongyan Chai, Weizhen Ji, Yufei Lu, Shengming Wu, Hongyu Zhao, Peining Li, Qiping Hu
Publikováno v:
BMC Medical Genomics, Vol 14, Iss 1, Pp 1-9 (2021)
Abstract Background Oligonucleotide array comparative genomic hybridization (aCGH) analysis has been used for detecting somatic copy number alterations (CNAs) in various types of tumors. This study aimed to assess the clinical utility of aCGH for cas
Externí odkaz:
https://doaj.org/article/a92696e840d642dbac06369a4ed04501
Autor:
Kaja C. G. Berg, Tuva H. Brunsell, Anita Sveen, Sharmini Alagaratnam, Merete Bjørnslett, Merete Hektoen, Kristoffer W. Brudvik, Bård I. Røsok, Bjørn Atle Bjørnbeth, Arild Nesbakken, Ragnhild A. Lothe
Publikováno v:
Molecular Oncology, Vol 15, Iss 4, Pp 830-845 (2021)
Hepatic resection is potentially curative for patients with colorectal liver metastases, but the treatment benefit varies. KRAS/NRAS (RAS)/TP53 co‐mutations are associated with a poor prognosis after resection, but there is large variation in patie
Externí odkaz:
https://doaj.org/article/d2dbfb57bdf24a8294717b68cf6264b2
Autor:
Filippo Martignano, Uday Munagala, Stefania Crucitta, Alessandra Mingrino, Roberto Semeraro, Marzia Del Re, Iacopo Petrini, Alberto Magi, Silvestro G. Conticello
Publikováno v:
Molecular Cancer, Vol 20, Iss 1, Pp 1-6 (2021)
Abstract In the “precision oncology” era the characterization of tumor genetic features is a pivotal step in cancer patients’ management. Liquid biopsy approaches, such as analysis of cell-free DNA from plasma, represent a powerful and noninvas
Externí odkaz:
https://doaj.org/article/8485a2ddff774172b10e1d66802a9ae3