Zobrazeno 1 - 10
of 44
pro vyhledávání: '"Coppoc GL"'
Autor:
Dennis B. DeNicola, J. Catharine Scott-Moncrieff, James R. Cook, Myra L. Samuels, Thomas C.K. Chan, Coppoc Gl, Ralph C. Richardson
Publikováno v:
Cancer Chemotherapy and Pharmacology. 29:13-18
Cytosine arabinoside (ara-C) is a component of many protocols for the treatment of CNS (central nervous system) leukemia and lymphoma in humans and dogs. It is also used for the prophylaxis of CNS metastasis in acute lymphoblastic leukemia. Although
Publikováno v:
Journal of Animal Science. 55:145-152
Studies were conducted to determine the absorption and metabolic fate of 3H-estradiol-17 beta-glucuronide (3H-E2-G) in swine. The conjugate, 3H-E2-G (48.7 x 10(6) DPM, 45.5 Ci/mmol), was injected into ligated 15-cm sections of duodenum, proximal jeju
Publikováno v:
Journal of Animal Science. 45:674-685
Publikováno v:
Journal of Animal Science. 55:135-144
Studies were conducted to determine the absorption and metabolic fate of orally administered 3H-estradiol-17 beta-glucuronide (3H-E2-G) in swine. Xylazine-tranquilized female pigs (5 to 6 wk old) were given .04, .4 or 4 mumol 3H-E2-G via stomach tube
Publikováno v:
Journal of Animal Science. 55:124-134
One minute after instillation of 14C-estradiol-17 beta (14C-E2 17 beta) into selected sections of the gastrointestinal tract of swine, radioactive estradiol metabolites were present in blood collected from the portal and jugular veins. Ether was used
Publikováno v:
Antimicrobial Agents and Chemotherapy. 20:387-392
Most clinical schemes used to adjust gentamicin dosage regimens in renal insufficiency assume that the volume of distribution remains constant. The purpose of this investigation was to determine the pharmacokinetic parameters of gentamicin (two-compa
Publikováno v:
Journal of Veterinary Pharmacology and Therapeutics. 2:235-239
Autor:
J. Edmond Riviere, Gary C. Lantz, Coppoc Gl, William W. Carlton, Michael P. Carver, Janet S. Shy-Modjeska
Publikováno v:
Toxicology and applied pharmacology. 75(3)
There is presently no consensus as to the relative safety of fixed-interval/reduced dose (FI) vs fixed-dose/increased interval (FD) dosage adjustment regiments for use in renal insufficiency. This study compared their nephrotoxic potential using gent
Publikováno v:
Veterinary research communications. 7(1-4)
A toxic nephropathy induced by gentamicin was investigated in young beagles and foals. Preliminary results indicated that a single 15 mg/kg dose of gentamicin administered to beagles produced subclinical functional and morphological changes in the ki
Publikováno v:
Fundamental and applied toxicology : official journal of the Society of Toxicology. 3(5)
Gentamicin pharmacokinetics and nephrotoxic potential were evaluated in twelve 2 to 3 month-old horses. Whereas recent evidence in our clinic indicated that young horses may be especially susceptible to gentamicin nephrotoxicity, young rabbits and ra