Dysregulated Wnt/β-catenin signaling confers resistance to cuproptosis in cancer cells.

Autor: Liu YT; State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, Key Laboratory of Oral Biomedicine Ministry of Education, Hubei Key Laboratory of Stomatology, School & Hospital of Stomatology, Frontier Science Center for Immunology and Metabolism, Taikang Center for Life and Medical Sciences, Wuhan University, Wuhan, China., Chen L; State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, Key Laboratory of Oral Biomedicine Ministry of Education, Hubei Key Laboratory of Stomatology, School & Hospital of Stomatology, Frontier Science Center for Immunology and Metabolism, Taikang Center for Life and Medical Sciences, Wuhan University, Wuhan, China., Li SJ; State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, Key Laboratory of Oral Biomedicine Ministry of Education, Hubei Key Laboratory of Stomatology, School & Hospital of Stomatology, Frontier Science Center for Immunology and Metabolism, Taikang Center for Life and Medical Sciences, Wuhan University, Wuhan, China., Wang WY; State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, Key Laboratory of Oral Biomedicine Ministry of Education, Hubei Key Laboratory of Stomatology, School & Hospital of Stomatology, Frontier Science Center for Immunology and Metabolism, Taikang Center for Life and Medical Sciences, Wuhan University, Wuhan, China., Wang YY; State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, Key Laboratory of Oral Biomedicine Ministry of Education, Hubei Key Laboratory of Stomatology, School & Hospital of Stomatology, Frontier Science Center for Immunology and Metabolism, Taikang Center for Life and Medical Sciences, Wuhan University, Wuhan, China., Yang QC; State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, Key Laboratory of Oral Biomedicine Ministry of Education, Hubei Key Laboratory of Stomatology, School & Hospital of Stomatology, Frontier Science Center for Immunology and Metabolism, Taikang Center for Life and Medical Sciences, Wuhan University, Wuhan, China., Song A; State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, Key Laboratory of Oral Biomedicine Ministry of Education, Hubei Key Laboratory of Stomatology, School & Hospital of Stomatology, Frontier Science Center for Immunology and Metabolism, Taikang Center for Life and Medical Sciences, Wuhan University, Wuhan, China., Zhang MJ; State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, Key Laboratory of Oral Biomedicine Ministry of Education, Hubei Key Laboratory of Stomatology, School & Hospital of Stomatology, Frontier Science Center for Immunology and Metabolism, Taikang Center for Life and Medical Sciences, Wuhan University, Wuhan, China., Mo WT; State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, Key Laboratory of Oral Biomedicine Ministry of Education, Hubei Key Laboratory of Stomatology, School & Hospital of Stomatology, Frontier Science Center for Immunology and Metabolism, Taikang Center for Life and Medical Sciences, Wuhan University, Wuhan, China., Li H; State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, Key Laboratory of Oral Biomedicine Ministry of Education, Hubei Key Laboratory of Stomatology, School & Hospital of Stomatology, Frontier Science Center for Immunology and Metabolism, Taikang Center for Life and Medical Sciences, Wuhan University, Wuhan, China., Hu CY; Department of Stomatology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. chuanyuhu@hust.edu.cn., Sun ZJ; State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, Key Laboratory of Oral Biomedicine Ministry of Education, Hubei Key Laboratory of Stomatology, School & Hospital of Stomatology, Frontier Science Center for Immunology and Metabolism, Taikang Center for Life and Medical Sciences, Wuhan University, Wuhan, China. sunzj@whu.edu.cn.

Publikováno v: Cell death and differentiation [Cell Death Differ] 2024 Nov; Vol. 31 (11), pp. 1452-1466. Date of Electronic Publication: 2024 Jul 10.

Aberrant copper metabolism and hepatic inflammation cause neurological manifestations in a mouse model of Wilson's disease.

Autor: Dong J; Institute of Neurology, Anhui University of Chinese Medicine, 357, Changjiang Rd. Middle, Hefei, Anhui, 230061, China.; Center for Xin-An Medicine and Modernization of Traditional Chinese Medicine of IHM, Anhui University of Chinese Medicine, Hefei, 230012, China., Xiang G; Key Laboratory of Immune Response and Immunotherapy, Institute of Health and Medicine, Hefei Comprehensive National Science Center, Hefei, 230601, China., Xia X; Institute of Neurology, Anhui University of Chinese Medicine, 357, Changjiang Rd. Middle, Hefei, Anhui, 230061, China., Xu L; Institute of Neurology, Anhui University of Chinese Medicine, 357, Changjiang Rd. Middle, Hefei, Anhui, 230061, China., Wen P; Institute of Neurology, Anhui University of Chinese Medicine, 357, Changjiang Rd. Middle, Hefei, Anhui, 230061, China., Xu C; Institute of Neurology, Anhui University of Chinese Medicine, 357, Changjiang Rd. Middle, Hefei, Anhui, 230061, China., Xu Y; Institute of Neurology, Anhui University of Chinese Medicine, 357, Changjiang Rd. Middle, Hefei, Anhui, 230061, China., Su Y; School of Life Sciences, Anhui Medical University, Hefei, 230032, China., Song Y; Institute of Zoology, Chinese Academy of Sciences, University of Chinese Academy of Sciences, 1 Beichen West Rd, Beijing, 100101, China., Tong H; High Magnetic Field Laboratory, Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei, 230031, China., Zhu Q; High Magnetic Field Laboratory, Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei, 230031, China., Han Y; Institute of Neurology, Anhui University of Chinese Medicine, 357, Changjiang Rd. Middle, Hefei, Anhui, 230061, China.; Center for Xin-An Medicine and Modernization of Traditional Chinese Medicine of IHM, Anhui University of Chinese Medicine, Hefei, 230012, China., Han Y; Institute of Neurology, Anhui University of Chinese Medicine, 357, Changjiang Rd. Middle, Hefei, Anhui, 230061, China.; Center for Xin-An Medicine and Modernization of Traditional Chinese Medicine of IHM, Anhui University of Chinese Medicine, Hefei, 230012, China., Cheng N; Institute of Neurology, Anhui University of Chinese Medicine, 357, Changjiang Rd. Middle, Hefei, Anhui, 230061, China. NanCheng111065@ahtcm.edu.cn.; Center for Xin-An Medicine and Modernization of Traditional Chinese Medicine of IHM, Anhui University of Chinese Medicine, Hefei, 230012, China. NanCheng111065@ahtcm.edu.cn., Wang H; Institute of Zoology, Chinese Academy of Sciences, University of Chinese Academy of Sciences, 1 Beichen West Rd, Beijing, 100101, China. wanghaoyi@ioz.ac.cn., Zhou H; School of Life Sciences, Anhui Medical University, Hefei, 230032, China. hzhou@ahmu.edu.cn.; School of Basic Medical Science, Anhui Medical University, Hefei, 230032, China. hzhou@ahmu.edu.cn.

Publikováno v: Journal of neuroinflammation [J Neuroinflammation] 2024 Sep 27; Vol. 21 (1), pp. 235. Date of Electronic Publication: 2024 Sep 27.

FoxO1 silencing in Atp7b ^-/- neural stem cells attenuates high copper-induced apoptosis via regulation of autophagy.

Autor: Zhang Y; Department of Neurology, First Affiliated Hospital of Anhui University of Traditional Chinese Medicine, Hefei, China.; Department of Graduate School, Anhui University of Chinese Medicine, Hefei, China., Wang M; Department of Neurology, First Affiliated Hospital of Anhui University of Traditional Chinese Medicine, Hefei, China.; Center for Xin'an Medicine and Modernization of Traditional Chinese Medicine of IHM, Anhui University of Chinese Medicine, Hefei, China., Tang L; Department of Neurology, First Affiliated Hospital of Anhui University of Traditional Chinese Medicine, Hefei, China., Yang W; Department of Neurology, First Affiliated Hospital of Anhui University of Traditional Chinese Medicine, Hefei, China.; Center for Xin'an Medicine and Modernization of Traditional Chinese Medicine of IHM, Anhui University of Chinese Medicine, Hefei, China., Zhang J; Department of Neurology, First Affiliated Hospital of Anhui University of Traditional Chinese Medicine, Hefei, China.; Center for Xin'an Medicine and Modernization of Traditional Chinese Medicine of IHM, Anhui University of Chinese Medicine, Hefei, China.

Publikováno v: Journal of neurochemistry [J Neurochem] 2024 Sep; Vol. 168 (9), pp. 2762-2774. Date of Electronic Publication: 2024 Jun 04.

Copper impairs the intestinal barrier integrity in Wilson disease.

Autor: Fontes A; Institute of Molecular Toxicology and Pharmacology, Helmholtz Center Munich, German Research Center for Environmental Health, Neuherberg, Germany; CNC-Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal; DCV-Department of Life Sciences, Faculty of Sciences and Technology of the University of Coimbra, Coimbra, Portugal., Pierson H; Department of Physiology, Johns Hopkins Medical Institutes, Baltimore, MD, USA., Bierła JB; Department of Pathomorphology, Children's Memorial Health Institute, Al. Dzieci Polskich 20, 04-730 Warsaw, Poland., Eberhagen C; Institute of Molecular Toxicology and Pharmacology, Helmholtz Center Munich, German Research Center for Environmental Health, Neuherberg, Germany., Kinschel J; Technical University Munich, Institute of Toxicology and Environmental Hygiene, Munich, Germany., Akdogan B; Institute of Molecular Toxicology and Pharmacology, Helmholtz Center Munich, German Research Center for Environmental Health, Neuherberg, Germany., Rieder T; Technical University Munich, Institute of Toxicology and Environmental Hygiene, Munich, Germany., Sailer J; Technical University Munich, Institute of Toxicology and Environmental Hygiene, Munich, Germany., Reinold Q; Technical University Munich, Institute of Toxicology and Environmental Hygiene, Munich, Germany., Cielecka-Kuszyk J; Department of Pathomorphology, Children's Memorial Health Institute, Al. Dzieci Polskich 20, 04-730 Warsaw, Poland., Szymańska S; Department of Pathomorphology, Children's Memorial Health Institute, Al. Dzieci Polskich 20, 04-730 Warsaw, Poland., Neff F; Munich Clinic Harlaching, Munich, Germany., Steiger K; Comparative Experimental Pathology Department, Institute for General Pathology and Pathological Anatomy, Technical University of Munich (TUM), Germany., Seelbach O; Comparative Experimental Pathology Department, Institute for General Pathology and Pathological Anatomy, Technical University of Munich (TUM), Germany., Zibert A; Medizinische Klinik B für Gastroenterologie und Hepatologie, Universitätsklinikum Münster, Münster, Germany., Schmidt HH; Medizinische Klinik B für Gastroenterologie und Hepatologie, Universitätsklinikum Münster, Münster, Germany., Hauck SM; Research Unit Protein Science, Helmholtz Center Munich, German Research Center for Environmental Health GmbH, Munich, Germany., von Toerne C; Research Unit Protein Science, Helmholtz Center Munich, German Research Center for Environmental Health GmbH, Munich, Germany., Michalke B; Research Unit Analytical BioGeoChemistry, Helmholtz Center Munich, German Research Center for Environmental Health, Neuherberg, Germany., Semrau JD; Department of Civil and Environmental Engineering, University of Michigan, Ann Arbor, MI, 48109-2125, USA., DiSpirito AM; Roy J. Carver Department of Biochemistry, Biophysics and Molecular Biology, Iowa State University, Ames, USA., Ramalho-Santos J; CNC-Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal; DCV-Department of Life Sciences, Faculty of Sciences and Technology of the University of Coimbra, Coimbra, Portugal; CIBB-Center for Innovative Biomedicine and Biotechnology (CIBB), University of Coimbra, Coimbra, Portugal., Kroemer G; Centre de Recherche des Cordeliers, Equipe labellisée par la Ligue contre le cancer, Université Paris Cité, Sorbonne Université, Inserm U1138, Institut Universitaire de France, Paris, France; Metabolomics and Cell Biology Platforms, Institut Gustave Roussy, Villejuif, France; Institut du Cancer Paris CARPEM, Department of Biology, Hôpital Européen Georges Pompidou, AP-, HP, Paris, France., Polishchuk R; Telethon Institute of Genetics and Medicine, 80078 Pozzuoli, Italy., Azul AM; CNC-Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal; CIBB-Center for Innovative Biomedicine and Biotechnology (CIBB), University of Coimbra, Coimbra, Portugal; IIIUC-Institute for Interdisciplinary Research, University of Coimbra, Coimbra, Portugal., DiSpirito A; Roy J. Carver Department of Biochemistry, Biophysics and Molecular Biology, Iowa State University, Ames, USA., Socha P; Department of Gastroenterology, Hepatology, Nutritional Disorders and Pediatrics, Children's Memorial Health Institute, Al. Dzieci Polskich 20, 04-730 Warsaw, Poland., Lutsenko S; Department of Physiology, Johns Hopkins Medical Institutes, Baltimore, MD, USA., Zischka H; Institute of Molecular Toxicology and Pharmacology, Helmholtz Center Munich, German Research Center for Environmental Health, Neuherberg, Germany; Technical University Munich, Institute of Toxicology and Environmental Hygiene, Munich, Germany. Electronic address: hans.zischka@helmholtz-munich.de.

Publikováno v: Metabolism: clinical and experimental [Metabolism] 2024 Sep; Vol. 158, pp. 155973. Date of Electronic Publication: 2024 Jul 08.

Wilson's disease in Sardinian population: The experience of a pediatric referral center.

Autor: Loudianos G; Clinica Pediatrica e Malattie Rare, Università degli Studi di Cagliari, Ospedale Pediatrico Microcitemico, Antonio Cao, Cagliari, Italy., Satta S; Laboratorio di Genetica e Genomica, Dipartimento di Scienze Mediche e Sanità Pubblica, Università degli Studi di Cagliari, Cagliari, Italy., Lepori MB; Laboratorio di Genetica e Genomica, Dipartimento di Scienze Mediche e Sanità Pubblica, Università degli Studi di Cagliari, Cagliari, Italy., Anni F; Laboratorio di Genetica e Genomica, Dipartimento di Scienze Mediche e Sanità Pubblica, Università degli Studi di Cagliari, Cagliari, Italy., Balloi R; SSD Endocrinologia Pediatrica e Centro Screening Neonatale, Ospedale Pediatrico, Microcitemico, A. Cao, Cagliari, Italy., Soddu C; Clinica Pediatrica e Malattie Rare, Università degli Studi di Cagliari, Ospedale Pediatrico Microcitemico, Antonio Cao, Cagliari, Italy., Fenu ML; Clinica Pediatrica e Malattie Rare, Università degli Studi di Cagliari, Ospedale Pediatrico Microcitemico, Antonio Cao, Cagliari, Italy., Lilliu F; Clinica Pediatrica e Malattie Rare, Università degli Studi di Cagliari, Ospedale Pediatrico Microcitemico, Antonio Cao, Cagliari, Italy., Nurchi AM; Clinica Pediatrica e Malattie Rare, Università degli Studi di Cagliari, Ospedale Pediatrico Microcitemico, Antonio Cao, Cagliari, Italy., De Virgiliis S; Clinica Pediatrica e Malattie Rare, Università degli Studi di Cagliari, Ospedale Pediatrico Microcitemico, Antonio Cao, Cagliari, Italy.

Publikováno v: Journal of pediatric gastroenterology and nutrition [J Pediatr Gastroenterol Nutr] 2024 Oct; Vol. 79 (4), pp. 807-817. Date of Electronic Publication: 2024 Aug 07.