Prophylactic evaluation of verubecestat on disease- and symptom-modifying effects in 5XFAD mice.

Autor: Oblak AL; Indiana University School of Medicine Indianapolis Indiana USA., Cope ZA; University of Pittsburgh School of Medicine Pittsburgh Pennsylvania USA., Quinney SK; Indiana University School of Medicine Indianapolis Indiana USA., Pandey RS; The Jackson Laboratory for Genomic Medicine Farmington Connecticut USA.; The Jackson Laboratory Bar Harbor Maine USA., Biesdorf C; Indiana University School of Medicine Indianapolis Indiana USA., Masters AR; Indiana University School of Medicine Indianapolis Indiana USA., Onos KD; University of California Irvine California USA., Haynes L; University of California Irvine California USA., Keezer KJ; University of California Irvine California USA., Meyer JA; Indiana University School of Medicine Indianapolis Indiana USA., Peters JS; Indiana University School of Medicine Indianapolis Indiana USA., Persohn SA; Indiana University School of Medicine Indianapolis Indiana USA., Bedwell AA; Indiana University School of Medicine Indianapolis Indiana USA., Eldridge K; Indiana University School of Medicine Indianapolis Indiana USA., Speedy R; Indiana University School of Medicine Indianapolis Indiana USA., Little G; University of Pittsburgh School of Medicine Pittsburgh Pennsylvania USA., Williams SP; University of Pittsburgh School of Medicine Pittsburgh Pennsylvania USA., Noarbe B; University of California Irvine California USA., Obenaus A; University of California Irvine California USA., Sasner M; The Jackson Laboratory Bar Harbor Maine USA., Howell GR; The Jackson Laboratory for Genomic Medicine Farmington Connecticut USA.; University of California Irvine California USA., Carter GW; The Jackson Laboratory for Genomic Medicine Farmington Connecticut USA.; University of California Irvine California USA., Williams H; The Jackson Laboratory Bar Harbor Maine USA., Lamb BT; Indiana University School of Medicine Indianapolis Indiana USA., Territo PR; Indiana University School of Medicine Indianapolis Indiana USA., Sukoff Rizzo SJ; University of Pittsburgh School of Medicine Pittsburgh Pennsylvania USA.; The Jackson Laboratory Bar Harbor Maine USA.

Publikováno v: Alzheimer's & dementia (New York, N. Y.) [Alzheimers Dement (N Y)] 2022 Jul 14; Vol. 8 (1), pp. e12317. Date of Electronic Publication: 2022 Jul 14 (Print Publication: 2022).

Comprehensive Evaluation of the 5XFAD Mouse Model for Preclinical Testing Applications: A MODEL-AD Study.

Autor: Oblak AL; Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, IN, United States.; Stark Neurosciences Research Institute, Indiana University School of Medicine, Indianapolis, IN, United States., Lin PB; Stark Neurosciences Research Institute, Indiana University School of Medicine, Indianapolis, IN, United States., Kotredes KP; The Jackson Laboratory, Bar Harbor, ME, United States., Pandey RS; The Jackson Laboratory, Bar Harbor, ME, United States., Garceau D; The Jackson Laboratory, Bar Harbor, ME, United States., Williams HM; The Jackson Laboratory, Bar Harbor, ME, United States., Uyar A; The Jackson Laboratory, Bar Harbor, ME, United States., O'Rourke R; The Jackson Laboratory, Bar Harbor, ME, United States., O'Rourke S; The Jackson Laboratory, Bar Harbor, ME, United States., Ingraham C; Stark Neurosciences Research Institute, Indiana University School of Medicine, Indianapolis, IN, United States., Bednarczyk D; The Jackson Laboratory, Bar Harbor, ME, United States., Belanger M; Department of Medicine, University of Pittsburgh, Pittsburgh, PA, United States., Cope ZA; Department of Medicine, University of Pittsburgh, Pittsburgh, PA, United States., Little GJ; Department of Medicine, University of Pittsburgh, Pittsburgh, PA, United States., Williams SG; Department of Medicine, University of Pittsburgh, Pittsburgh, PA, United States., Ash C; Stark Neurosciences Research Institute, Indiana University School of Medicine, Indianapolis, IN, United States., Bleckert A; The Jackson Laboratory for Genomic Medicine, Farmington, CT, United States., Ragan T; The Jackson Laboratory for Genomic Medicine, Farmington, CT, United States., Logsdon BA; Sage Bionetworks, Seattle, WA, United States., Mangravite LM; Sage Bionetworks, Seattle, WA, United States., Sukoff Rizzo SJ; Department of Medicine, University of Pittsburgh, Pittsburgh, PA, United States., Territo PR; Stark Neurosciences Research Institute, Indiana University School of Medicine, Indianapolis, IN, United States.; Department of Medicine, Indiana University School of Medicine, Indianapolis, IN, United States., Carter GW; The Jackson Laboratory, Bar Harbor, ME, United States., Howell GR; The Jackson Laboratory, Bar Harbor, ME, United States., Sasner M; The Jackson Laboratory, Bar Harbor, ME, United States., Lamb BT; Stark Neurosciences Research Institute, Indiana University School of Medicine, Indianapolis, IN, United States.; Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN, United States.

Publikováno v: Frontiers in aging neuroscience [Front Aging Neurosci] 2021 Jul 23; Vol. 13, pp. 713726. Date of Electronic Publication: 2021 Jul 23 (Print Publication: 2021).

Converging evidence that short-active photoperiod increases acetylcholine signaling in the hippocampus.

Autor: Cope ZA; Department of Psychiatry, University of California San Diego, 9500 Gilman Drive MC 0804, La Jolla, CA, 92093-0804, USA.; University of Pittsburgh Aging Institute, Pittsburgh, PA, USA., Lavadia ML; Department of Psychiatry, University of California San Diego, 9500 Gilman Drive MC 0804, La Jolla, CA, 92093-0804, USA., Joosen AJM; Division of Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, The Netherlands., van de Cappelle CJA; Division of Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, The Netherlands., Lara JC; Department of Psychiatry, University of California San Diego, 9500 Gilman Drive MC 0804, La Jolla, CA, 92093-0804, USA., Huval A; Department of Psychiatry, University of California San Diego, 9500 Gilman Drive MC 0804, La Jolla, CA, 92093-0804, USA., Kwiatkowski MK; Department of Psychiatry, University of California San Diego, 9500 Gilman Drive MC 0804, La Jolla, CA, 92093-0804, USA., Picciotto MR; Department of Psychiatry, Yale School of Medicine, New Haven, CT, USA., Mineur YS; Department of Psychiatry, Yale School of Medicine, New Haven, CT, USA., Dulcis D; Department of Psychiatry, University of California San Diego, 9500 Gilman Drive MC 0804, La Jolla, CA, 92093-0804, USA., Young JW; Department of Psychiatry, University of California San Diego, 9500 Gilman Drive MC 0804, La Jolla, CA, 92093-0804, USA. jaredyoung@ucsd.edu.; Research Service, VA San Diego Healthcare System, San Diego, CA, USA. jaredyoung@ucsd.edu.

Publikováno v: Cognitive, affective & behavioral neuroscience [Cogn Affect Behav Neurosci] 2020 Dec; Vol. 20 (6), pp. 1173-1183.

Evidence for light-entrainment-induced switching between depression- & mania-relevant behaviors in mice.

Autor: Young JW; Department of Psychiatry, University of California San Diego, 9500 Gilman Drive MC 0804, La Jolla, CA, 92093-0804, USA. jaredyoung@ucsd.edu.; Research Service, VA San Diego Healthcare System, San Diego, CA, USA. jaredyoung@ucsd.edu., Cope ZA; Department of Psychiatry, University of California San Diego, 9500 Gilman Drive MC 0804, La Jolla, CA, 92093-0804, USA., Romoli B; Department of Psychiatry, University of California San Diego, 9500 Gilman Drive MC 0804, La Jolla, CA, 92093-0804, USA., Schrurs E; Department of Psychiatry, University of California San Diego, 9500 Gilman Drive MC 0804, La Jolla, CA, 92093-0804, USA.; Division of Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, The Netherlands., Joosen A; Department of Psychiatry, University of California San Diego, 9500 Gilman Drive MC 0804, La Jolla, CA, 92093-0804, USA.; Division of Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, The Netherlands., van Enkhuizen J; Department of Psychiatry, University of California San Diego, 9500 Gilman Drive MC 0804, La Jolla, CA, 92093-0804, USA., Sharp RF; Department of Psychiatry, University of California San Diego, 9500 Gilman Drive MC 0804, La Jolla, CA, 92093-0804, USA., Dulcis D; Department of Psychiatry, University of California San Diego, 9500 Gilman Drive MC 0804, La Jolla, CA, 92093-0804, USA. ddulcis@ucsd.edu.

Publikováno v: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology [Neuropsychopharmacology] 2019 Sep; Vol. 44 (10), pp. 1679-1680. Date of Electronic Publication: 2019 Feb 20.

DREADD-mediated modulation of locus coeruleus inputs to mPFC improves strategy set-shifting.

Autor: Cope ZA; Department of Psychiatry, University of California San Diego, 9500 Gilman Dr. MC 0804, La Jolla, CA 92093-0804, United States., Vazey EM; Department of Biology, University of Massachusetts, 611 North Pleasant St, Amherst, MA 01003, United States., Floresco SB; Department of Psychology and Djavad Mowafaghian Centre for Brain Health, University of British Columbia, 2136 West Mall, Vancouver, BC V6T 1Z4, Canada., Aston Jones GS; Brain Health Institute, Rutgers University/Rutgers Biomedical and Health Sciences, 683 Hoes Lane West, Office 259A, Piscataway, NJ 08854, United States. Electronic address: bhi@ca.rutgers.edu.

Publikováno v: Neurobiology of learning and memory [Neurobiol Learn Mem] 2019 May; Vol. 161, pp. 1-11. Date of Electronic Publication: 2019 Feb 22.