Novel methodology to discern predictors of remission and patterns of disease activity over time using rheumatoid arthritis clinical trials data

Autor: Tom, BDM, Symmons, D, Brockbank, S, Carini, C, Cope, AP, Ehrenstein, MR, Fisher, BA, Goodyear, CS, Gozzard, N, Harris, R, Hicks, K, Hollis, S, Hughes-Morley, A, Isaacs, J, Kola, B, McInnes, IB, Mela, CM, Parker, G, Pedersen, AW, Ponchel, F, Sabin, T, Scott, DL, Scott, IC, Sleeman, MA, Taylor, PC, Tsuji, W, Zhong, Y, Hilkens, C, Anderson, A, Stocks, P, Lendrem, D, Tarn, J, Smith, G, Allen, B, Casement, J, Diboll, J, Harry, R, Simpson, G, Toward, R, Noble, H, Parke, A, Wu, W, Clarke, F, Galloway, J, Lempp, H, Ibrahim, F, Schwank, S, Molyneux, G, Lazarov, T, Geissmann, F, Donnelly, I, Gilmour, A, Virlan, AT, Porter, D, Emery, P, El-Jawhari, J, Parmar, R, McDermot, MF, Buch, M, Buckley, C, Young, SP, Jones, P, Raza, K, Filer, A, Pitzalis, C, Barnes, MR, Watson, DS, Tzanis, E, Thorborn, G, Fossati-Jimack, L, Kelly, S, Humby, F, Bombardieri, M, Rana, S, Jia, Z, Goldmann, K, Lewis, M, Altobelli, G, John, C, Martins, S, Nguyen, D, Ali, H, Ciurtin, C, Worthington, J, Bruce, IN, Sergeant, JC, Verstappen, SMM, Stirling, F, Farewell, V, Keidel, S, Cuff, C, Levesque, M, Long, A, Liu, Z, Lipsky, S, Harvey, B, Macoritto, M, Hong, F, Kaymakcalan, S, Ward, N, Talbot, S, Padhji, D, Sleeman, M, Finch, D, Herath, A, Lindholm, C, Jenkins, M, Ho, M, Marshall, C, Page, M, Edwards, H, Cuza, A, Rowe, A, Capdevila, FB, Loza, M, Curran, M, Verbeeck, D, Baker, D, Vranic, I, Mela, CT, Wright, S, Rowell, L, Vernon, E, Joseph, N, Payne, N, Rao, R, Binks, M, Belson, A, Ludbrook, V, Tipney, H, Ellis, J, Hasan, S, Didierlaurent, A, Burny, W, Haynes, A, Larminie, C, Dastros-Pitel, D, Jelinsky, S, Hodge, M, Maciejewski, M, Ziemek, D, Schulz-Knappe, P, Zucht, H-D, Budde, P, Coles, MC, Butler, JA, Read, S, Consortium, RA-MAP

Objectives: To identify predictors of remission and disease activity patterns in patients with rheumatoid arthritis (RA) using individual participant data (IPD) from clinical trials. Methods: Phase II and III clinical trials completed between 2002 an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=core_ac_uk__::4ac11814e901364bf7dcec578a58a963
https://eprints.whiterose.ac.uk/143215/11/e000721.full.pdf

The RA-MAP Consortium: a working model for academia-industry collaboration

Autor: Cope, AP, Barnes, MR, Belson, A, Binks, M, Brockbank, S, Bonachela-Capdevila, F, Carini, C, Fisher, BA, Goodyear, CS, Emery, P, Ehrenstein, MR, Gozzard, N, Harris, R, Hollis, S, Keidel, S, Levesque, M, Lindholm, C, McDermott, MF, McInnes, IB, Mela, CM, Parker, G, Read, S, Pedersen, AW, Ponchel, F, Porter, D, Rao, R, Rowe, A, Schulz-Knappe, P, Sleeman, MA, Symmons, D, Taylor, PC, Tom, B, Tsuji, W, Verbeeck, D, Isaacs, JD, Consortium, Ra-Map

Publikováno v: The RA-MAP Consortium, Symmons, D & Sergeant, J 2017, ' The RA-MAP Consortium: a working model for academic-industry collaboration ', Nature Reviews Rheumatology, vol. 14, pp. 53-60 . https://doi.org/10.1038/nrrheum.2017.200

Collaboration can be challenging; nevertheless, the emerging successes of large, multi-partner, multi-national cooperatives and research networks in the biomedical sector have sustained the appetite of academics and industry partners for developing a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8fa80a6a87b81a291405f8290bdbc81e

Predicting the risk of rheumatoid arthritis and its age of onset through modelling genetic risk variants with smoking

Autor: Scott, IC, Seegobin, SD, Steer, S, Tan, R, Forabosco, P, Hinks, A, Eyre, S, Morgan, AW, Wilson, AG, Hocking, LJ, Wordsworth, P, Barton, A, Worthington, J, Cope, AP, Lewis, CM

Publikováno v: PLoS Genetics, Vol 9, Iss 9, p e1003808 (2013)
PLoS Genetics

The improved characterisation of risk factors for rheumatoid arthritis (RA) suggests they could be combined to identify individuals at increased disease risks in whom preventive strategies may be evaluated. We aimed to develop an RA prediction model

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::a33ac6bc67c09ce36ba667a68a578f6d
https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24068971/?tool=EBI

How does tumour necrosis factor uncouple T-cell receptor-induced IL-2 gene expression in murine T cells?

Autor: Clark, JM, Aleksiyadis, K, Panesar, M, Cope, AP

Publikováno v: Arthritis Research & Therapy

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmc_________::ca66d6cbf9e5765e8f82237dce2b870e
http://europepmc.org/articles/PMC2834040

A subset of memory effector T cells in peripheral blood defined by differential expression of the TCR-ζ chain

Autor: Zhang, Z, Panesar, N, Cope, AP

Publikováno v: Arthritis Research & Therapy

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmc_________::00b29a18efe6504fa9ffc3a157f2f21b
http://europepmc.org/articles/PMC2833681