Shared neutrophil and T cell dysfunction is accompanied by a distinct interferon signature during severe febrile illnesses in children

Autor: Harsita Patel, Michael J. Carter, Heather Jackson, Oliver Powell, Matthew Fish, Manuela Terranova-Barberio, Filomena Spada, Nedyalko Petrov, Paul Wellman, Sarah Darnell, Sobia Mustafa, Katrina Todd, Cynthia Bishop, Jonathan M. Cohen, Julia Kenny, Sarah van den Berg, Thomas Sun, Francesca Davis, Aislinn Jennings, Emma Timms, Jessica Thomas, Maggie Nyirendra, Samuel Nichols, Leire Estamiana Elorieta, Giselle D’Souza, Victoria Wright, Tisham De, Dominic Habgood-Coote, Padmanabhan Ramnarayan, Pierre Tissières, Elizabeth Whittaker, Jethro Herberg, Aubrey Cunnington, Myrsini Kaforou, Richard Ellis, Michael H. Malim, Shane M. Tibby, Manu Shankar-Hari, Michael Levin, On behalf of the DIAMONDS Consortium

Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)

Abstract Severe febrile illnesses in children encompass life-threatening organ dysfunction caused by diverse pathogens and other severe inflammatory syndromes. A comparative approach to these illnesses may identify shared and distinct features of hos

Externí odkaz: https://doaj.org/article/d2c0c6faa08d407fae3fa0e21cb48076

Evaluating the Safety and Efficacy of Telemedicine Physician Assessments on a Mobile Stroke Unit: Protocol for a Prospective Open‐Label Blinded End‐Point Randomized Controlled Trial

Autor: Vignan Yogendrakumar, Anna H. Balabanski, Hannah Johns, Leonid Churilov, Nicola K. Parsons, James Beharry, Louise Weir, Nawaf Yassi, Henry Zhao, Alex Warwick, Skye Coote, Francesca Langenberg, Leigh Branagan, Wasseem Siddiqi, Andrew Bivard, Bruce C. V. Campbell, Geoffrey A. Donnan, Stephen M. Davis

Publikováno v: Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 13, Iss 21 (2024)

Background Mobile stroke units have been shown to deliver faster patient care and improve clinical outcomes. However, costs associated with staffing limit their use to densely populated cities. Using the Melbourne mobile stroke unit, we aim to evalua

Externí odkaz: https://doaj.org/article/40ce316dacf14ec9b7426da63e6b4e18

Challenge of cardiovascular prevention in primary care: achievement of lifestyle, blood pressure, lipids and diabetes targets for primary prevention in England – results from ASPIRE-3-PREVENT cross-sectional survey

Autor: A Brown, Richard Hobbs, S Jones, J Davies, S Taylor, D Wood, J Cook, T Mason, J Clarke, C Brown, N Ghuman, R Fox, C Jones, S Uddin, J Wilson, C Bell, H Wilson, David Wood, Kornelia Kotseva, Agnieszka Adamska, A Adamska, S Adamska, C Jennings, K Kotseva, P Atkin, C Thomas, A Oliver, C Cox, A Dunne, D Kelly, M Stone, K Beck, J Taylor, S Hunt, J Ryan, P Griffiths, D Shukla, S Richardson, P Steadman, V Glover, N Coote, D Corbett, C Gibbon, F Doyle, L Owen, C Thornley, S Dean, S McKee, N Chauhan, J Howell, R Coles, R Hobbs, K Duff, M Arthur, Catriona Jennings, D Lonsdale, L Steel, T Holt, L Rosenberg, S Cartwright, J Rooney, N Qamar, S Shillito, M Zerominska, U Khan O Hussein, A Ballintine, A Isaew, S Spannuth, J Timmins, F Spannuth, A Agasou, L Andrew, R Hibbell, S Hollishead, S Mazilu-Wood, M Oakley, J Simm, T Nyguyen, C Talbot, R Crowe, K Hollier, T Hembrough, R Symonds, D Diprose, J Beecham, S Bosel-Doyle, L S Taylor, K Priddis, C Winch, S Wytrykowski, Dr L Jones, E Ogburn, N Wooding, S Maslen, C Naylo, R Horsley, H Nobeebaccus, E Tomlinson, L Chaytor, S Garnham, Z Martin, S Mononga, S Steed, S Galbraith-Gibbons, T Sevenoaks

Publikováno v: Open Heart, Vol 11, Iss 2 (2024)

Background Implementation of the cardiovascular disease (CVD) prevention guidelines in the UK has been repeatedly evaluated under the auspices of the British Cardiovascular Society in three Action on Secondary and Primary Prevention by Intervention t

Externí odkaz: https://doaj.org/article/6b748f79da934306af127a3405272dde

A computational framework to improve cross-platform implementation of transcriptomics signatures

Autor: Louis Kreitmann, Giselle D'Souza, Luca Miglietta, Ortensia Vito, Heather R. Jackson, Dominic Habgood-Coote, Michael Levin, Alison Holmes, Myrsini Kaforou, Jesus Rodriguez-Manzano

Publikováno v: EBioMedicine, Vol 105, Iss , Pp 105204- (2024)

Summary: The emergence of next-generation sequencing technologies and computational advances have expanded our understanding of gene expression regulation (i.e., the transcriptome). This has also led to an increased interest in using transcriptomic b

Externí odkaz: https://doaj.org/article/8e90b0ada34d43efb995ce8260a11d3c

Organ Shape Sensing using Pneumatically Attachable Flexible Rails in Robotic-Assisted Laparoscopic Surgery

Autor: McDonald-Bowyer, Aoife, Dietsch, Solène, Dimitrakakis, Emmanouil, Coote, Joanna M, Lindenroth, Lukas, Stoyanov, Danail, Stilli, Agostino

In robotic-assisted partial nephrectomy, surgeons remove a part of a kidney often due to the presence of a mass. A drop-in ultrasound probe paired to a surgical robot is deployed to execute multiple swipes over the kidney surface to localise the mass

Externí odkaz: http://arxiv.org/abs/2202.10977