Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Coorens Thh"'
Autor:
Ayesha Noorani, Coorens Thh, Oliver Trw, Thomas J. Mitchell, Michael R. Stratton, Raheleh Rahbari, James Hewinson, Peter J. Campbell, Alex Cagan, Luiza Moore, Christopher J, Rashesh Sanghvi, Rebecca C. Fitzgerald, Neville Mdc, Philip S. Robinson, Inigo Martincorena, Yvette Hooks
Starting from the zygote, all cells in the developing and adult human body continuously acquire mutations. A mutation shared between two different cells implies a shared progenitor cell and can thus be used as a naturally occurring marker for lineage
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c6556a56a671440b18c411a8da2b715b
https://doi.org/10.1101/2020.11.25.397828
https://doi.org/10.1101/2020.11.25.397828
Autor:
Yu Z; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Cardiovascular Research Center and Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA., Coorens THH; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Uddin MM; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Cardiovascular Research Center and Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA., Ardlie KG; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Lennon N; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Natarajan P; Broad Institute of MIT and Harvard, Cambridge, MA, USA. pnatarajan@mgh.harvard.edu.; Cardiovascular Research Center and Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA. pnatarajan@mgh.harvard.edu.; Department of Medicine, Harvard Medical School, Boston, MA, USA. pnatarajan@mgh.harvard.edu.
Publikováno v:
Nature reviews. Genetics [Nat Rev Genet] 2024 Aug; Vol. 25 (8), pp. 548-562. Date of Electronic Publication: 2024 Mar 28.
Autor:
Coorens THH; Wellcome Sanger Institute, Hinxton, UK. tcoorens@broadinstitute.org.; Broad Institute of MIT and Harvard, Cambridge, MA, USA. tcoorens@broadinstitute.org., Spencer Chapman M; Wellcome Sanger Institute, Hinxton, UK. ms56@sanger.ac.uk.; Department of Haematology, Barts Health NHS Trust, London, UK. ms56@sanger.ac.uk.; Department of Haemato-oncology, Barts Cancer Institute, Queen Mary University of London, London, UK. ms56@sanger.ac.uk., Williams N; Wellcome Sanger Institute, Hinxton, UK., Martincorena I; Wellcome Sanger Institute, Hinxton, UK., Stratton MR; Wellcome Sanger Institute, Hinxton, UK., Nangalia J; Wellcome Sanger Institute, Hinxton, UK.; Wellcome-Medical Research Council Cambridge Stem Cell Institute, Cambridge, UK.; Department of Haematology, University of Cambridge, Cambridge, UK., Campbell PJ; Wellcome Sanger Institute, Hinxton, UK. pc8@sanger.ac.uk.; Wellcome-Medical Research Council Cambridge Stem Cell Institute, Cambridge, UK. pc8@sanger.ac.uk.
Publikováno v:
Nature protocols [Nat Protoc] 2024 Jun; Vol. 19 (6), pp. 1866-1886. Date of Electronic Publication: 2024 Feb 23.
Autor:
Ijaz J; Wellcome Sanger Institute, Hinxton CB10 1SA, UK. Electronic address: jijaz@altoslabs.com., Harry E; Wellcome Sanger Institute, Hinxton CB10 1SA, UK., Raine K; Wellcome Sanger Institute, Hinxton CB10 1SA, UK; Health Innovation East, Unit C, Magog Court, Shelford Bottom, Cambridge CB22 3AD, UK., Menzies A; Wellcome Sanger Institute, Hinxton CB10 1SA, UK., Beal K; Wellcome Sanger Institute, Hinxton CB10 1SA, UK., Quail MA; Wellcome Sanger Institute, Hinxton CB10 1SA, UK., Zumalave S; Mobile Genomes and Disease, Center for Research in Molecular Medicine and Chronic Diseases (CiMUS), Universidade de Santiago de Compostela, 15706 Santiago de Compostela, Spain., Jung H; Wellcome Sanger Institute, Hinxton CB10 1SA, UK., Coorens THH; Wellcome Sanger Institute, Hinxton CB10 1SA, UK; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Lawson ARJ; Wellcome Sanger Institute, Hinxton CB10 1SA, UK., Leongamornlert D; Wellcome Sanger Institute, Hinxton CB10 1SA, UK., Francies HE; Wellcome Sanger Institute, Hinxton CB10 1SA, UK; GSK, Gunnels Wood Road, Stevenage SG1 2NY, UK., Garnett MJ; Wellcome Sanger Institute, Hinxton CB10 1SA, UK., Ning Z; Wellcome Sanger Institute, Hinxton CB10 1SA, UK., Campbell PJ; Wellcome Sanger Institute, Hinxton CB10 1SA, UK. Electronic address: pc8@sanger.ac.uk.
Publikováno v:
Cell genomics [Cell Genom] 2024 Feb 14; Vol. 4 (2), pp. 100484. Date of Electronic Publication: 2024 Jan 16.
Autor:
Treger TD; Wellcome Sanger Institute, Hinxton, CB10 1SA, UK.; Department of Paediatrics, University of Cambridge, Cambridge, CB2 0QQ, UK.; Cambridge University Hospitals NHS Foundation Trust, Cambridge, CB2 0QQ, UK., Lawrence JEG; Wellcome Sanger Institute, Hinxton, CB10 1SA, UK.; Cambridge University Hospitals NHS Foundation Trust, Cambridge, CB2 0QQ, UK., Anderson ND; Wellcome Sanger Institute, Hinxton, CB10 1SA, UK., Coorens THH; Broad Institute of MIT and Harvard, Cambridge, 02142 MA, USA., Letunovska A; UCL Great Ormond Street Institute of Child Health, London, WC1N 1EH, UK.; NIHR Great Ormond Street Hospital Biomedical Research Centre, London, WC1N 3JH, UK., Abby E; Wellcome Sanger Institute, Hinxton, CB10 1SA, UK., Lee-Six H; Wellcome Sanger Institute, Hinxton, CB10 1SA, UK.; Department of Pathology, Cambridge University Hospitals NHS Foundation Trust, Cambridge, CB2 0QQ, UK., Oliver TRW; Wellcome Sanger Institute, Hinxton, CB10 1SA, UK.; Department of Pathology, Cambridge University Hospitals NHS Foundation Trust, Cambridge, CB2 0QQ, UK., Al-Saadi R; UCL Great Ormond Street Institute of Child Health, London, WC1N 1EH, UK.; NIHR Great Ormond Street Hospital Biomedical Research Centre, London, WC1N 3JH, UK., Tullus K; UCL Great Ormond Street Institute of Child Health, London, WC1N 1EH, UK.; NIHR Great Ormond Street Hospital Biomedical Research Centre, London, WC1N 3JH, UK., Morcrette G; UCL Great Ormond Street Institute of Child Health, London, WC1N 1EH, UK.; NIHR Great Ormond Street Hospital Biomedical Research Centre, London, WC1N 3JH, UK., Hutchinson JC; NIHR Great Ormond Street Hospital Biomedical Research Centre, London, WC1N 3JH, UK., Rampling D; NIHR Great Ormond Street Hospital Biomedical Research Centre, London, WC1N 3JH, UK., Sebire N; UCL Great Ormond Street Institute of Child Health, London, WC1N 1EH, UK.; NIHR Great Ormond Street Hospital Biomedical Research Centre, London, WC1N 3JH, UK., Pritchard-Jones K; UCL Great Ormond Street Institute of Child Health, London, WC1N 1EH, UK., Young MD; Wellcome Sanger Institute, Hinxton, CB10 1SA, UK., Mitchell TJ; Wellcome Sanger Institute, Hinxton, CB10 1SA, UK.; Cambridge University Hospitals NHS Foundation Trust, Cambridge, CB2 0QQ, UK.; Early Cancer Institute, University of Cambridge, Cambridge, CB2 0XZ, UK., Jones PH; Wellcome Sanger Institute, Hinxton, CB10 1SA, UK.; Department of Oncology, University of Cambridge, Cambridge, CB2 OXZ, UK., Tran M; Specialist Centre for Kidney Cancer, Royal Free Hospital, London, NW3 2QG, UK. m.tran@ucl.ac.uk.; Faculty of Medical Sciences, Division of Surgery and Interventional Science, University College London, London, NW3 2PS, UK. m.tran@ucl.ac.uk., Behjati S; Wellcome Sanger Institute, Hinxton, CB10 1SA, UK. sb31@sanger.ac.uk.; Department of Paediatrics, University of Cambridge, Cambridge, CB2 0QQ, UK. sb31@sanger.ac.uk.; Cambridge University Hospitals NHS Foundation Trust, Cambridge, CB2 0QQ, UK. sb31@sanger.ac.uk., Chowdhury T; UCL Great Ormond Street Institute of Child Health, London, WC1N 1EH, UK. Tanzina.Chowdhury@gosh.nhs.uk.; NIHR Great Ormond Street Hospital Biomedical Research Centre, London, WC1N 3JH, UK. Tanzina.Chowdhury@gosh.nhs.uk.
Publikováno v:
Nature communications [Nat Commun] 2023 Sep 25; Vol. 14 (1), pp. 5826. Date of Electronic Publication: 2023 Sep 25.
Autor:
Coorens THH; Broad Institute of MIT and Harvard, Cambridge, MA, USA. tcoorens@broadinstitute.org., Collord G; Great Ormond Street Hospital for Children, London, UK., Treger TD; Wellcome Sanger Institute, Hinxton, UK.; Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.; Department of Paediatrics, University of Cambridge, Cambridge, UK., Adams S; Great Ormond Street Hospital for Children, London, UK., Mitchell E; Wellcome Sanger Institute, Hinxton, UK.; Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK., Newman B; Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK., Getz G; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Cancer Center and Department of Pathology, Massachusetts General Hospital, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA., Godfrey AL; Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK., Bartram J; Great Ormond Street Hospital for Children, London, UK., Behjati S; Wellcome Sanger Institute, Hinxton, UK. sb31@sanger.ac.uk.; Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK. sb31@sanger.ac.uk.; Department of Paediatrics, University of Cambridge, Cambridge, UK. sb31@sanger.ac.uk.
Publikováno v:
Nature cancer [Nat Cancer] 2023 Aug; Vol. 4 (8), pp. 1095-1101. Date of Electronic Publication: 2023 Jul 20.
Autor:
Ellis P; Cancer, Ageing and Somatic Mutation (CASM), Wellcome Sanger Institute, Hinxton, UK.; Inivata Limited, The Glenn Berge Building, Babraham Research Campus, Babraham, UK., Moore L; Cancer, Ageing and Somatic Mutation (CASM), Wellcome Sanger Institute, Hinxton, UK., Sanders MA; Cancer, Ageing and Somatic Mutation (CASM), Wellcome Sanger Institute, Hinxton, UK.; Department of Hematology, Erasmus University Medical Center, Rotterdam, the Netherlands., Butler TM; Cancer, Ageing and Somatic Mutation (CASM), Wellcome Sanger Institute, Hinxton, UK., Brunner SF; Cancer, Ageing and Somatic Mutation (CASM), Wellcome Sanger Institute, Hinxton, UK., Lee-Six H; Cancer, Ageing and Somatic Mutation (CASM), Wellcome Sanger Institute, Hinxton, UK., Osborne R; Cancer, Ageing and Somatic Mutation (CASM), Wellcome Sanger Institute, Hinxton, UK.; Inivata Limited, The Glenn Berge Building, Babraham Research Campus, Babraham, UK., Farr B; Cancer, Ageing and Somatic Mutation (CASM), Wellcome Sanger Institute, Hinxton, UK., Coorens THH; Cancer, Ageing and Somatic Mutation (CASM), Wellcome Sanger Institute, Hinxton, UK., Lawson ARJ; Cancer, Ageing and Somatic Mutation (CASM), Wellcome Sanger Institute, Hinxton, UK., Cagan A; Cancer, Ageing and Somatic Mutation (CASM), Wellcome Sanger Institute, Hinxton, UK., Stratton MR; Cancer, Ageing and Somatic Mutation (CASM), Wellcome Sanger Institute, Hinxton, UK., Martincorena I; Cancer, Ageing and Somatic Mutation (CASM), Wellcome Sanger Institute, Hinxton, UK., Campbell PJ; Cancer, Ageing and Somatic Mutation (CASM), Wellcome Sanger Institute, Hinxton, UK. pc8@sanger.ac.uk.
Publikováno v:
Nature protocols [Nat Protoc] 2023 Jun; Vol. 18 (6), pp. 1979.
Autor:
Wang Y; Cancer, Ageing and Somatic Mutation, Wellcome Sanger Institute, Hinxton, UK., Robinson PS; Cancer, Ageing and Somatic Mutation, Wellcome Sanger Institute, Hinxton, UK.; Department of Paediatrics, University of Cambridge, Cambridge, UK., Coorens THH; Cancer, Ageing and Somatic Mutation, Wellcome Sanger Institute, Hinxton, UK.; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Moore L; Cancer, Ageing and Somatic Mutation, Wellcome Sanger Institute, Hinxton, UK.; Department of Pathology, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK., Lee-Six H; Cancer, Ageing and Somatic Mutation, Wellcome Sanger Institute, Hinxton, UK., Noorani A; Cancer, Ageing and Somatic Mutation, Wellcome Sanger Institute, Hinxton, UK., Sanders MA; Cancer, Ageing and Somatic Mutation, Wellcome Sanger Institute, Hinxton, UK., Jung H; Cancer, Ageing and Somatic Mutation, Wellcome Sanger Institute, Hinxton, UK., Katainen R; Applied Tumor Genomics Research Program, Faculty of Medicine, University of Helsinki, Helsinki, Finland., Heuschkel R; Department of Paediatric Gastroenterology, Hepatology and Nutrition, Addenbrooke's Hospital, Cambridge, UK., Brunton-Sim R; Norfolk and Norwich University Hospital, Norwich, UK., Weston R; NIHR Clinical Research Network-East of England, Addenbrooke's Hospital, Cambridge, UK., Read D; NIHR Clinical Research Network-East of England, Addenbrooke's Hospital, Cambridge, UK., Nobbs B; NIHR Clinical Research Network-East of England, Addenbrooke's Hospital, Cambridge, UK., Fitzgerald RC; The Early Cancer Institute, Department of Oncology, University of Cambridge, Cambridge, UK., Saeb-Parsy K; Department of Surgery and Cambridge NIHR Biomedical Research Centre, Biomedical Campus, University of Cambridge, Cambridge, UK., Martincorena I; Cancer, Ageing and Somatic Mutation, Wellcome Sanger Institute, Hinxton, UK., Campbell PJ; Cancer, Ageing and Somatic Mutation, Wellcome Sanger Institute, Hinxton, UK., Rushbrook S; Norfolk and Norwich University Hospital, Norwich, UK.; Norwich Medical School, University of East Anglia, Norwich, UK., Zilbauer M; Department of Paediatrics, University of Cambridge, Cambridge, UK.; Department of Paediatric Gastroenterology, Hepatology and Nutrition, Addenbrooke's Hospital, Cambridge, UK., Buczacki SJA; Nuffield Department of Surgical Sciences, Medical Sciences Division, University of Oxford, Oxford, UK., Stratton MR; Cancer, Ageing and Somatic Mutation, Wellcome Sanger Institute, Hinxton, UK. mrs@sanger.ac.uk.
Publikováno v:
Nature genetics [Nat Genet] 2023 Feb; Vol. 55 (2), pp. 246-254. Date of Electronic Publication: 2023 Jan 26.
Autor:
Oliver TRW; Wellcome Sanger Institute, Hinxton, UK.; Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK., Chappell L; Wellcome Sanger Institute, Hinxton, UK., Sanghvi R; Wellcome Sanger Institute, Hinxton, UK., Deighton L; Wellcome Sanger Institute, Hinxton, UK., Ansari-Pour N; Big Data Institute, Nuffield Department of Medicine, University of Oxford, Oxford, UK.; MRC Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK., Dentro SC; Wellcome Sanger Institute, Hinxton, UK.; European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Cambridge, UK., Young MD; Wellcome Sanger Institute, Hinxton, UK., Coorens THH; Wellcome Sanger Institute, Hinxton, UK., Jung H; Wellcome Sanger Institute, Hinxton, UK., Butler T; Wellcome Sanger Institute, Hinxton, UK., Neville MDC; Wellcome Sanger Institute, Hinxton, UK., Leongamornlert D; Wellcome Sanger Institute, Hinxton, UK., Sanders MA; Wellcome Sanger Institute, Hinxton, UK.; Department of Hematology, Erasmus University Medical Center, Rotterdam, The Netherlands., Hooks Y; Wellcome Sanger Institute, Hinxton, UK., Cagan A; Wellcome Sanger Institute, Hinxton, UK., Mitchell TJ; Wellcome Sanger Institute, Hinxton, UK.; Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK., Cortes-Ciriano I; European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Cambridge, UK., Warren AY; Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK., Wedge DC; Big Data Institute, Nuffield Department of Medicine, University of Oxford, Oxford, UK.; Manchester Cancer Research Centre, Division of Cancer Sciences, University of Manchester, Manchester, UK., Heer R; Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK.; Newcastle Urology, Freeman Hospital, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK., Coleman N; Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.; Department of Pathology, University of Cambridge, Cambridge, UK., Murray MJ; Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.; Department of Pathology, University of Cambridge, Cambridge, UK., Campbell PJ; Wellcome Sanger Institute, Hinxton, UK., Rahbari R; Wellcome Sanger Institute, Hinxton, UK. rr11@sanger.ac.uk., Behjati S; Wellcome Sanger Institute, Hinxton, UK. sb31@sanger.ac.uk.; Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK. sb31@sanger.ac.uk.; Department of Paediatrics, University of Cambridge, Cambridge, UK. sb31@sanger.ac.uk.
Publikováno v:
Nature communications [Nat Commun] 2022 Aug 11; Vol. 13 (1), pp. 4272. Date of Electronic Publication: 2022 Aug 11.
Autor:
Robinson PS; Cancer, Ageing and Somatic Mutation (CASM), Wellcome Sanger Institute, Hinxton, CB10 1SA, UK.; Department of Paediatrics, University of Cambridge, Cambridge, CB2 0QQ, UK., Thomas LE; Institute of Life Science, Swansea University, Swansea, SA28PP, UK., Abascal F; Cancer, Ageing and Somatic Mutation (CASM), Wellcome Sanger Institute, Hinxton, CB10 1SA, UK., Jung H; Cancer, Ageing and Somatic Mutation (CASM), Wellcome Sanger Institute, Hinxton, CB10 1SA, UK., Harvey LMR; Cancer, Ageing and Somatic Mutation (CASM), Wellcome Sanger Institute, Hinxton, CB10 1SA, UK., West HD; Institute of Medical Genetics, Division of Cancer and Genetics, Cardiff University School of Medicine, Cardiff, UK., Olafsson S; Cancer, Ageing and Somatic Mutation (CASM), Wellcome Sanger Institute, Hinxton, CB10 1SA, UK., Lee BCH; Cancer, Ageing and Somatic Mutation (CASM), Wellcome Sanger Institute, Hinxton, CB10 1SA, UK.; Hereditary Gastrointestinal Cancer Genetic Diagnosis Laboratory, Department of Pathology, The University of Hong Kong, Queen Mary Hospital, Pokfulam, Hong Kong., Coorens THH; Cancer, Ageing and Somatic Mutation (CASM), Wellcome Sanger Institute, Hinxton, CB10 1SA, UK., Lee-Six H; Cancer, Ageing and Somatic Mutation (CASM), Wellcome Sanger Institute, Hinxton, CB10 1SA, UK., Butlin L; Institute of Medical Genetics, Division of Cancer and Genetics, Cardiff University School of Medicine, Cardiff, UK., Lander N; Institute of Medical Genetics, Division of Cancer and Genetics, Cardiff University School of Medicine, Cardiff, UK., Truscott R; Institute of Medical Genetics, Division of Cancer and Genetics, Cardiff University School of Medicine, Cardiff, UK., Sanders MA; Cancer, Ageing and Somatic Mutation (CASM), Wellcome Sanger Institute, Hinxton, CB10 1SA, UK.; Department of Haematology, Erasmus University Medical Centre, 3015 CN, Rotterdam, The Netherlands., Lensing SV; Cancer, Ageing and Somatic Mutation (CASM), Wellcome Sanger Institute, Hinxton, CB10 1SA, UK., Buczacki SJA; Nuffield Department of Surgical Sciences, Medical Sciences Division, University of Oxford, Oxford, UK., Ten Hoopen R; Department of Oncology, University of Cambridge, Cambridge, UK., Coleman N; Department of Pathology, University of Cambridge, Cambridge, UK.; Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK., Brunton-Sim R; Norfolk and Norwich University Hospital, Norwich, UK., Rushbrook S; Norfolk and Norwich University Hospital, Norwich, UK.; Norwich Medical School, University of East Anglia, Norwich, UK., Saeb-Parsy K; Department of Surgery, University of Cambridge, Cambridge, UK.; Cambridge NIHR Biomedical Research Centre, Cambridge Biomedical Campus, Cambridge, UK., Lalloo F; Manchester Centre for Genomic Medicine, Saint Mary's Hospital, Oxford Road, Manchester, UK., Campbell PJ; Cancer, Ageing and Somatic Mutation (CASM), Wellcome Sanger Institute, Hinxton, CB10 1SA, UK., Martincorena I; Cancer, Ageing and Somatic Mutation (CASM), Wellcome Sanger Institute, Hinxton, CB10 1SA, UK., Sampson JR; Institute of Medical Genetics, Division of Cancer and Genetics, Cardiff University School of Medicine, Cardiff, UK., Stratton MR; Cancer, Ageing and Somatic Mutation (CASM), Wellcome Sanger Institute, Hinxton, CB10 1SA, UK. mrs@sanger.ac.uk.
Publikováno v:
Nature communications [Nat Commun] 2022 Jul 08; Vol. 13 (1), pp. 3949. Date of Electronic Publication: 2022 Jul 08.