Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Coorens, Tim HH"'
Autor:
Wang, Yichen, Robinson, Philip S, Coorens, Tim HH, Moore, Luiza, Lee-Six, Henry, Noorani, Ayesha, Sanders, Mathijs A, Jung, Hyunchul, Katainen, Riku, Heuschkel, Robert, Brunton-Sim, Roxanne, Weston, Robyn, Read, Debbie, Nobbs, Beverley, Fitzgerald, Rebecca C, Saeb-Parsy, Kourosh, Martincorena, Iñigo, Campbell, Peter J, Rushbrook, Simon, Zilbauer, Matthias, Buczacki, Simon James Alexander, Stratton, Michael R
Funder: Core funding from the Wellcome Sanger Institute (Wellcome Trust, No. 206194).
Funder: Wellcome PhD Studentship (Wellcome Trust, No. 206194)
Funder: Wellcome Clinical PhD fellowship (Wellcome Trust, No. 206194)
Funder: Pathologi
Funder: Wellcome PhD Studentship (Wellcome Trust, No. 206194)
Funder: Wellcome Clinical PhD fellowship (Wellcome Trust, No. 206194)
Funder: Pathologi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce450c5fa23fb6a868f4f4b1b109ca78
http://hdl.handle.net/10138/356436
http://hdl.handle.net/10138/356436
Autor:
Robinson, Philip S, Thomas, Laura E, Abascal, Federico, Jung, Hyunchul, Harvey, Luke MR, West, Hannah D, Olafsson, Sigurgeir, Lee, Bernard CH, Coorens, Tim HH, Lee-Six, Henry, Butlin, Laura, Lander, Nicola, Truscott, Rebekah, Sanders, Mathijs A, Lensing, Stefanie V, Buczacki, Simon JA, Ten Hoopen, Rogier, Coleman, Nicholas, Brunton-Sim, Roxanne, Rushbrook, Simon, Saeb-Parsy, Kourosh, Lalloo, Fiona, Campbell, Peter J, Martincorena, Iñigo, Sampson, Julian R, Stratton, Michael R
Publikováno v:
Nature Communications
Nature Communications, 13(1):3949. Nature Publishing Group
Nature Communications, 13(1):3949. Nature Publishing Group
Cellular DNA damage caused by reactive oxygen species is repaired by the base excision repair (BER) pathway which includes the DNA glycosylase MUTYH. Inherited biallelic MUTYH mutations cause predisposition to colorectal adenomas and carcinoma. Howev
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94b339d2bb3a0704547a8f297ede6899
http://www.scopus.com/inward/record.url?scp=85133717829&partnerID=8YFLogxK
http://www.scopus.com/inward/record.url?scp=85133717829&partnerID=8YFLogxK
Autor:
Spencer Chapman, Michael, Ranzoni, Anna Maria, Myers, Brynelle, Williams, Nicholas, Coorens, Tim HH, Mitchell, Emily, Butler, Timothy, Dawson, Kevin J, Hooks, Yvette, Moore, Luiza, Nangalia, Jyoti, Robinson, Philip S, Yoshida, Kenichi, Hook, Elizabeth, Campbell, Peter J, Cvejic, Ana
The ontogeny of the human haematopoietic system during fetal development has previously been characterized mainly through careful microscopic observations1. Here we reconstruct a phylogenetic tree of blood development using whole-genome sequencing of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb8434db84150b66caa8d8680b28b92c
https://www.repository.cam.ac.uk/handle/1810/321318
https://www.repository.cam.ac.uk/handle/1810/321318
Autor:
Coorens, Tim HH, Collord, Grace, Lu, Wanhua, Mitchell, Emily, Ijaz, Jannat, Roberts, Thomas, Oliver, Thomas RW, Burke, GA Amos, Gattens, Michael, Dickens, Emmy, Nangalia, Jyoti, Tischkowitz, Marc, Anderson, John, Shlien, Adam, Godfrey, Anna L, Murray, Matthew J, Behjati, Sam
Therapy-related myeloid neoplasms (TMN) constitute one of the most challengingcomplications of cancer treatment.1 Whilst understanding of TMN pathogenesis remains fragmentary, genomic studies in adults have thus far refuted the notion that TMN simply
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62bfb0d23268e999e6e4f8b88a4bb5ad
https://www.repository.cam.ac.uk/handle/1810/317248
https://www.repository.cam.ac.uk/handle/1810/317248
Autor:
Young, Matthew D, Mitchell, Thomas J, Custers, Lars MC, Khabirova, Eleonora, Oliver, Thomas RW, Comitani, Federico, Piapi, Alice, Blanco, Eva Bugallo, Thevanesan, Christine, Roberts, Kenny, Braga, Felipe A Vieira, Coorens, Tim HH, Del Valle, Ignacio, Wilbrey-Clark, Anna, Mamanova, Lira, Stewart, Grant D, Gnagapragasam, Vincent J, Rampling, Dyanne, Sebire, Neil, Coleman, Nicholas, Hook, Liz, Warren, Anne, Haniffa, Muzlifah, Kool, Marcel, Pfister, Stefan M, Achermann, John C, He, Xiaoling, Barker, Roger A, Shlien, Adam, Bayraktar, Omer A, Teichmann, Sarah, Meyer, Kerstin B, Drost, Jarno, Straathof, Karin, Behjati, Sam
Tumor cells may produce many of the same messenger RNAs (mRNA) as the cell they derive from. The relative abundance of these mRNAs, the transcriptiomic profile, may provide clues into the origin and development of tumors. Here we investigated the cel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=sharebioRxiv::44ea3a6c350ed5f0cfab4351fb6694a1
Autor:
De Noon, Solange, Ijaz, Jannat, Coorens, Tim HH, Amary, Fernanda, Ye, Hongtao, Strobl, Anna, Lyskjær, Iben, Flanagan, Adrienne M, Behjati, Sam
Publikováno v:
Journal of Pathology: Clinical Research; Sep2021, Vol. 7 Issue 5, p425-431, 7p
Autor:
Stammnitz, Maximilian R, Coorens, Tim HH, Gori, Kevin C, Hayes, Dane, Fu, Beiyuan, Wang, Jinhong, Martin-Herranz, Daniel E, Alexandrov, Ludmil B, Baez-Ortega, Adrian, Barthorpe, Syd, Beck, Alexandra, Giordano, Francesca, Knowles, Graeme W, Kwon, Young Mi, Hall, George, Price, Stacey, Pye, Ruth J, Tubio, Jose MC, Siddle, Hannah VT, Sohal, Sukhwinder Singh, Woods, Gregory M, McDermott, Ultan, Yang, Fengtang, Garnett, Mathew J, Ning, Zemin, Murchison, Elizabeth P
Publikováno v:
Cancer Cell
Summary Transmissible cancers are clonal lineages that spread through populations via contagious cancer cells. Although rare in nature, two facial tumor clones affect Tasmanian devils. Here we perform comparative genetic and functional characterizati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84bda383d9a8e238c0a02c2660308562
https://www.repository.cam.ac.uk/handle/1810/273945
https://www.repository.cam.ac.uk/handle/1810/273945
Autor:
Mitchell, Emily, Spencer Chapman, Michael, Williams, Nicholas, Dawson, Kevin J, Mende, Nicole, Calderbank, Emily, Jung, Hyunchul, Mitchell, Thomas, Coorens, Tim HH, Spencer, David H, Machado, Heather, Lee-Six, Henry, Davies, Megan, Hayler, Daniel, Fabre, Margarete A, Mahbubani, Krishnaa, Abascal, Federico, Cagan, Alex, Vassiliou, George, Baxter, Joanna, Martincorena, Inigo, Stratton, Michael R, Kent, David G, Chatterjee, Krishna, Parsy, Kourosh Saeb, Green, Tony, Nangalia, Jyoti, Laurenti, Elisa, Campbell, Peter J
Publikováno v:
Nature. 606(7913):343-350
Funder: Medical Research Council
Age-related change in human haematopoiesis causes reduced regenerative capacity1, cytopenias2, immune dysfunction3 and increased risk of blood cancer4-6, but the reason for such abrupt functional decline after 70
Age-related change in human haematopoiesis causes reduced regenerative capacity1, cytopenias2, immune dysfunction3 and increased risk of blood cancer4-6, but the reason for such abrupt functional decline after 70
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b853a207a4cf372e212d826d0afcd801
Autor:
Abascal, Federico, Harvey, Luke MR, Mitchell, Emily, Lawson, Andrew RJ, Lensing, Stefanie V, Ellis, Peter, Russell, Andrew JC, Alcantara, Raul E, Baez-Ortega, Adrian, Wang, Yichen, Kwa, Eugene Jing, Lee-Six, Henry, Cagan, Alex, Coorens, Tim HH, Chapman, Michael Spencer, Olafsson, Sigurgeir, Leonard, Steven, Jones, David, Machado, Heather E, Davies, Megan, Øbro, Nina F, Mahubani, Krishnaa T, Allinson, Kieren, Gerstung, Moritz, Saeb-Parsy, Kourosh, Kent, David G, Laurenti, Elisa, Stratton, Michael R, Rahbari, Raheleh, Campbell, Peter J, Osborne, Robert J, Martincorena, Iñigo
Somatic mutations drive the development of cancer and may contribute to ageing and other diseases1,2. Despite their importance, the difficulty of detecting mutations that are only present in single cells or small clones has limited our knowledge of s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ebe3ad0191913d89e63026273c42c360
Autor:
Molè, Matteo A, Coorens, Tim HH, Shahbazi, Marta N, Weberling, Antonia, Weatherbee, Bailey AT, Gantner, Carlos W, Sancho-Serra, Carmen, Richardson, Lucy, Drinkwater, Abbie, Syed, Najma, Engley, Stephanie, Snell, Philip, Christie, Leila, Elder, Kay, Campbell, Alison, Fishel, Simon, Behjati, Sam, Vento-Tormo, Roser, Zernicka-Goetz, Magdalena
Following implantation, the human embryo undergoes major morphogenetic transformations that establish the future body plan. While the molecular events underpinning this process are established in mice, they remain unknown in humans. Here we character
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ad07800bf7cdc8820d5e4e6facc19fad