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Autor: Bush JT; GSK Medicines Research Centre, Gunnels Wood Road, Stevenage, Hertfordshire SG1 2NY, U.K., Pogany P; GSK Medicines Research Centre, Gunnels Wood Road, Stevenage, Hertfordshire SG1 2NY, U.K., Pickett SD; GSK Medicines Research Centre, Gunnels Wood Road, Stevenage, Hertfordshire SG1 2NY, U.K., Barker M; GSK Medicines Research Centre, Gunnels Wood Road, Stevenage, Hertfordshire SG1 2NY, U.K., Baxter A; GSK Medicines Research Centre, Gunnels Wood Road, Stevenage, Hertfordshire SG1 2NY, U.K., Campos S; GSK Medicines Research Centre, Gunnels Wood Road, Stevenage, Hertfordshire SG1 2NY, U.K., Cooper AWJ; GSK Medicines Research Centre, Gunnels Wood Road, Stevenage, Hertfordshire SG1 2NY, U.K., Hirst D; GSK Medicines Research Centre, Gunnels Wood Road, Stevenage, Hertfordshire SG1 2NY, U.K., Inglis G; GSK Medicines Research Centre, Gunnels Wood Road, Stevenage, Hertfordshire SG1 2NY, U.K., Nadin A; GSK Medicines Research Centre, Gunnels Wood Road, Stevenage, Hertfordshire SG1 2NY, U.K., Patel VK; GSK Medicines Research Centre, Gunnels Wood Road, Stevenage, Hertfordshire SG1 2NY, U.K., Poole D; GSK Medicines Research Centre, Gunnels Wood Road, Stevenage, Hertfordshire SG1 2NY, U.K., Pritchard J; GSK Medicines Research Centre, Gunnels Wood Road, Stevenage, Hertfordshire SG1 2NY, U.K., Washio Y; GSK Medicines Research Centre, Gunnels Wood Road, Stevenage, Hertfordshire SG1 2NY, U.K., White G; GSK Medicines Research Centre, Gunnels Wood Road, Stevenage, Hertfordshire SG1 2NY, U.K., Green DVS; GSK Medicines Research Centre, Gunnels Wood Road, Stevenage, Hertfordshire SG1 2NY, U.K.

Publikováno v: Journal of medicinal chemistry [J Med Chem] 2020 Oct 22; Vol. 63 (20), pp. 11964-11971. Date of Electronic Publication: 2020 Oct 12.

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Akademický článek

Discovery of a Bromodomain and Extraterminal Inhibitor with a Low Predicted Human Dose through Synergistic Use of Encoded Library Technology and Fragment Screening.

Autor: Wellaway CR; GSK , Gunnels Wood Road , Stevenage , Hertfordshire SG1 2NY , U.K., Amans D; GSK , Gunnels Wood Road , Stevenage , Hertfordshire SG1 2NY , U.K., Bamborough P; GSK , Gunnels Wood Road , Stevenage , Hertfordshire SG1 2NY , U.K., Barnett H; GSK , Gunnels Wood Road , Stevenage , Hertfordshire SG1 2NY , U.K., Bit RA; GSK , Gunnels Wood Road , Stevenage , Hertfordshire SG1 2NY , U.K., Brown JA; GSK , Gunnels Wood Road , Stevenage , Hertfordshire SG1 2NY , U.K., Carlson NR; GSK , 200 Cambridge Park Drive , Cambridge , Massachusetts 02140 , United States., Chung CW; GSK , Gunnels Wood Road , Stevenage , Hertfordshire SG1 2NY , U.K., Cooper AWJ; GSK , Gunnels Wood Road , Stevenage , Hertfordshire SG1 2NY , U.K., Craggs PD; GSK , Gunnels Wood Road , Stevenage , Hertfordshire SG1 2NY , U.K., Davis RP; GSK , Gunnels Wood Road , Stevenage , Hertfordshire SG1 2NY , U.K., Dean TW; GSK , Gunnels Wood Road , Stevenage , Hertfordshire SG1 2NY , U.K., Evans JP; GSK , Gunnels Wood Road , Stevenage , Hertfordshire SG1 2NY , U.K., Gordon L; GSK , Gunnels Wood Road , Stevenage , Hertfordshire SG1 2NY , U.K., Harada IL; GSK , Gunnels Wood Road , Stevenage , Hertfordshire SG1 2NY , U.K., Hirst DJ; GSK , Gunnels Wood Road , Stevenage , Hertfordshire SG1 2NY , U.K., Humphreys PG; GSK , Gunnels Wood Road , Stevenage , Hertfordshire SG1 2NY , U.K., Jones KL; GSK , Gunnels Wood Road , Stevenage , Hertfordshire SG1 2NY , U.K., Lewis AJ; GSK , Gunnels Wood Road , Stevenage , Hertfordshire SG1 2NY , U.K., Lindon MJ; GSK , Gunnels Wood Road , Stevenage , Hertfordshire SG1 2NY , U.K., Lugo D; GSK , Gunnels Wood Road , Stevenage , Hertfordshire SG1 2NY , U.K., Mahmood M; GSK , Gunnels Wood Road , Stevenage , Hertfordshire SG1 2NY , U.K., McCleary S; GSK , Gunnels Wood Road , Stevenage , Hertfordshire SG1 2NY , U.K., Medeiros P; GSK , 200 Cambridge Park Drive , Cambridge , Massachusetts 02140 , United States., Mitchell DJ; GSK , Gunnels Wood Road , Stevenage , Hertfordshire SG1 2NY , U.K., O'Sullivan M; GSK , Gunnels Wood Road , Stevenage , Hertfordshire SG1 2NY , U.K., Le Gall A; GSK , Gunnels Wood Road , Stevenage , Hertfordshire SG1 2NY , U.K., Patel VK; GSK , Gunnels Wood Road , Stevenage , Hertfordshire SG1 2NY , U.K., Patten C; GSK , Gunnels Wood Road , Stevenage , Hertfordshire SG1 2NY , U.K., Poole DL; GSK , Gunnels Wood Road , Stevenage , Hertfordshire SG1 2NY , U.K., Shah RR; GSK , Gunnels Wood Road , Stevenage , Hertfordshire SG1 2NY , U.K., Smith JE; GSK , Gunnels Wood Road , Stevenage , Hertfordshire SG1 2NY , U.K., Stafford KAJ; GSK , Gunnels Wood Road , Stevenage , Hertfordshire SG1 2NY , U.K., Thomas PJ; GSK , Gunnels Wood Road , Stevenage , Hertfordshire SG1 2NY , U.K., Vimal M; GSK , Gunnels Wood Road , Stevenage , Hertfordshire SG1 2NY , U.K., Wall ID; GSK , Gunnels Wood Road , Stevenage , Hertfordshire SG1 2NY , U.K., Watson RJ; GSK , Gunnels Wood Road , Stevenage , Hertfordshire SG1 2NY , U.K., Wellaway N; GSK , Gunnels Wood Road , Stevenage , Hertfordshire SG1 2NY , U.K., Yao G; GSK , 200 Cambridge Park Drive , Cambridge , Massachusetts 02140 , United States., Prinjha RK; GSK , Gunnels Wood Road , Stevenage , Hertfordshire SG1 2NY , U.K.

Publikováno v: Journal of medicinal chemistry [J Med Chem] 2020 Jan 23; Vol. 63 (2), pp. 714-746. Date of Electronic Publication: 2020 Jan 06.

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Akademický článek

Discovery of Potent, Efficient, and Selective Inhibitors of Phosphoinositide 3-Kinase δ through a Deconstruction and Regrowth Approach.

Autor: Barton N; GlaxoSmithKline R&D, Medicines Research Centre , Gunnels Wood Road , SG1 2NY Stevenage , U.K., Convery M; GlaxoSmithKline R&D, Medicines Research Centre , Gunnels Wood Road , SG1 2NY Stevenage , U.K., Cooper AWJ; GlaxoSmithKline R&D, Medicines Research Centre , Gunnels Wood Road , SG1 2NY Stevenage , U.K., Down K; GlaxoSmithKline R&D, Medicines Research Centre , Gunnels Wood Road , SG1 2NY Stevenage , U.K., Hamblin JN; GlaxoSmithKline R&D, Medicines Research Centre , Gunnels Wood Road , SG1 2NY Stevenage , U.K., Inglis G; GlaxoSmithKline R&D, Medicines Research Centre , Gunnels Wood Road , SG1 2NY Stevenage , U.K., Peace S; GlaxoSmithKline R&D, Medicines Research Centre , Gunnels Wood Road , SG1 2NY Stevenage , U.K., Rowedder J; GlaxoSmithKline R&D, Medicines Research Centre , Gunnels Wood Road , SG1 2NY Stevenage , U.K., Rowland P; GlaxoSmithKline R&D, Medicines Research Centre , Gunnels Wood Road , SG1 2NY Stevenage , U.K., Taylor JA; GlaxoSmithKline R&D, Medicines Research Centre , Gunnels Wood Road , SG1 2NY Stevenage , U.K., Wellaway N; GlaxoSmithKline R&D, Medicines Research Centre , Gunnels Wood Road , SG1 2NY Stevenage , U.K.

Publikováno v: Journal of medicinal chemistry [J Med Chem] 2018 Dec 27; Vol. 61 (24), pp. 11061-11073. Date of Electronic Publication: 2018 Dec 21.

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