Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Cooper A. Taylor"'
Autor:
Jerzy Osipiuk, Saara-Anne Azizi, Steve Dvorkin, Michael Endres, Robert Jedrzejczak, Krysten A. Jones, Soowon Kang, Rahul S. Kathayat, Youngchang Kim, Vladislav G. Lisnyak, Samantha L. Maki, Vlad Nicolaescu, Cooper A. Taylor, Christine Tesar, Yu-An Zhang, Zhiyao Zhou, Glenn Randall, Karolina Michalska, Scott A. Snyder, Bryan C. Dickinson, Andrzej Joachimiak
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-9 (2021)
The SARS-CoV-2 papain-like protease (PLpro) is of interest as an antiviral drug target. Here, the authors synthesize and characterise naphthalene-based inhibitors for PLpro and present the crystal structures of PLpro in its apo state and with the bou
Externí odkaz:
https://doaj.org/article/78bca1985cf441b2b78df027d7429e6e
Autor:
Cooper, Courtney Taylor
Seventeen new dithiophenyl- and napthodithiophenyl- fused porphyrins were synthesized; from these an additional 7 porphyrin oligomers were also synthesized. Additionally freebase 2,7-dimethoxytriphenylene fused porphyrin was also synthesized from a f
Externí odkaz:
https://digital.library.unt.edu/ark:/67531/metadc2179339/
Publikováno v:
Chemical Science
For decades, the Laurencia family of halogenated C15-acetogenins has served as a valuable testing ground for the prowess of chemical synthesis, particularly as it relates to generating functionalized 8-membered bromoethers. Herein, we show that a rea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb28b954d7b38889b0820f4bdb173a0a
https://pubmed.ncbi.nlm.nih.gov/34122807
https://pubmed.ncbi.nlm.nih.gov/34122807
Publikováno v:
Chemical Science
The recent natural product isolates spiroviolene and spirograterpene A are two relatively non-functionalized linear triquinane terpenes with a large number of structural homologies. Nevertheless, three significant areas of structural disparity exist
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e14f74525c3594a4f4f8d3a729478b1e
https://pubmed.ncbi.nlm.nih.gov/34094343
https://pubmed.ncbi.nlm.nih.gov/34094343
Autor:
Robert Jedrzejczak, Krysten A. Jones, Christine Tesar, Youngchang Kim, Karolina Michalska, Saara-Anne Azizi, Jerzy Osipiuk, Matthias Endres, Scott A. Snyder, Vladislav G. Lisnyak, Yu-An Zhang, Zhiyao Zhou, Samantha L. Maki, Soowon Kang, Bryan C. Dickinson, Andrzej Joachimiak, Rahul S. Kathayat, Glenn Randall, Steve Dvorkin, Vlad Nicolaescu, Cooper A. Taylor
Publikováno v:
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-9 (2021)
Nature Communications, Vol 12, Iss 1, Pp 1-9 (2021)
The pandemic caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) continues to expand. Papain-like protease (PLpro) is one of two SARS-CoV-2 proteases potentially targetable with antivirals. PLpro is an attractive target because it
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9626c66f6bf5b75f404ceb03a6f2c73
https://doi.org/10.1038/s41467-021-21060-3
https://doi.org/10.1038/s41467-021-21060-3
Autor:
Carol A. Parish, Lauren M. McRae, Bill R. Miller, Justin Airas, Neda Ojaghlou, Cooper A. Taylor
Publikováno v:
Journal of chemical information and modeling. 61(1)
Recent experiments indicate that the C-Jun amino-terminal kinase-interacting protein 1 (JIP1) binds to and activates the c-Jun N-terminal kinase (JNK) protein. JNK is an integral part of cell apoptosis, and misregulation of this process is a causativ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a27a3b40586306e1d8d2ade1573d62cf
https://pubmed.ncbi.nlm.nih.gov/33378183
https://pubmed.ncbi.nlm.nih.gov/33378183
Autor:
Thais R. Scott, Kathryn Humphries, Bill R. Miller, Carol A. Parish, Zach Stewart, Boyi Zhang, Andrew E. Pomerantz, Adam Luxon, Oliver C. Mullins, Hui Hu, Richard N. Zare, Shannon Houck, Weiguo Wang, Cooper A. Taylor, Arjun Jaini, Michael M Kitimet, Kevin John Ulep
Publikováno v:
Energy & Fuels. 31:9140-9151
Asphaltene nanoaggregates for three diverse source materials—coal-derived asphaltenes dominated by aromatic carbon, petroleum asphaltenes with comparable abundances of aromatic and aliphatic carbon, and immature source-rock asphaltenes dominated by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4bb03e72f55df2c554af2da68c2f76eb
https://doi.org/10.1021/acs.energyfuels.7b01420
https://doi.org/10.1021/acs.energyfuels.7b01420
Design and computational support for the binding stability of a new CCR5/CXCR4 dual tropic inhibitor
Publikováno v:
Journal of Molecular Graphics and Modelling. 75:71-79
The human immunodeficiency virus (HIV) infects healthy human cells by binding to the glycoprotein cluster of differentiation 4 receptors on the surface of helper T-cells, along with either of two chemokine receptors, CC chemokine receptor type 5 (CCR
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::642b4dca0bb7f1e0a3a64c5f5227b456
https://doi.org/10.1016/j.jmgm.2017.02.012
https://doi.org/10.1016/j.jmgm.2017.02.012
Autor:
Cooper A. Taylor, Hunter D. Evans, Julie A. Pollock, Kristen J. Rubenstein, Carol A. Parish, Quincy McKoy, Jessica Y. Kim, Justin Airas, Courtney L. Labrecque, Madeline L. Newkirk
Publikováno v:
Biochemistry. 57(34)
ErbB2 signaling pathways are linked to breast cancer formation, growth, and aggression; therefore, understanding the behavior of proteins associated with these pathways as well as regulatory factors that influence ErbB2 function is essential. MEMO1 i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f09e1c9f5fface612ebdcaf401d4ec3
https://pubmed.ncbi.nlm.nih.gov/30067338
https://pubmed.ncbi.nlm.nih.gov/30067338
A molecular dynamics study of the binary complexes of APP, JIP1, and the cargo binding domain of KLC
Publikováno v:
Proteins. 85(2)
Mutations in the Amyloid Precursor Protein (APP) are responsible for the formation of Amyloid-β peptides. These peptides play a role in Alzheimer's and other dementia-related diseases. The cargo binding domain of the kinesin-1 light chain motor prot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af6cb57a55c30fe6a9d1a4705e28b3f6
https://pubmed.ncbi.nlm.nih.gov/27891669
https://pubmed.ncbi.nlm.nih.gov/27891669