Preliminary demonstration of an allelic association of the IREB2 gene with Alzheimer's disease

Autor: Coon, K D, Siegel, A M, Yee, S J, Dunckley, T L, Mueller, C, Nagra, R M, Tourtellotte, W W, Reiman, E M, Papassotiropoulos, A, Petersen, F F, Stephan, D A, Kirsch, W M

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63c6dd90cb3df1e8629782f8ff8a557a
https://doi.org/10.5167/uzh-49383

Whole genome association analysis shows that ACE is a risk factor for Alzheimer's disease and fails to replicate most candidates from Meta-analysis

Autor: Webster, J., Reiman, E. M., Zismann, V. L., Joshipura, K. D., John Pearson, Hu-Lince, D., Huentelman, M. J., Craig, D. W., Coon, K. D., Beach, T., Rohrer, K. C., Zhao, A. S., Leung, D., Bryden, L., Marlowe, L., Kaleem, M., Mastroeni, D., Grover, A., Rogers, J., Heun, R., Jessen, F., Kölsch, H., Heward, C. B., Ravid, R., Hutton, M. L., Melquist, S., Petersen, R. C., Caselli, R. J., Papassotiropoulos, A., Stephan, D. A., Hardy, J., Myers, A.

Publikováno v: Europe PubMed Central
Scopus-Elsevier
International Journal of Molecular Epidemiology and Genetics, 1, 19-30. e-Century Publishing Corporation

For late onset Alzheimer's disease (LOAD), the only confirmed, genetic association is with the apolipoprotein E (APOE) locus on chromosome 19. Meta-analysis is often employed to sort the true associations from the false positives. LOAD research has t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::f03470d8c38f6b487636000b353c2a1d
http://europepmc.org/abstract/med/21537449