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Genomic screening reveals ubiquitin-like modifier activating enzyme 1 as a potent and druggable target in c-MYC-high triple negative breast cancer models.

Autor: Jacob S; Department of Oral and Craniofacial Molecular Biology, Philips Institute for Oral Health Research, VCU School of Dentistry and Massey Cancer Center, Virginia Commonwealth University, Richmond, VA 23298, USA., Turner TH; Department of Pathology, Virginia Commonwealth University School of Medicine, Richmond, VA 23298, USA.; Wright Center for Clinical and Translational Research, Virginia Commonwealth University School of Medicine, Richmond, VA 23298, USA., Cai J; Department of Oral and Craniofacial Molecular Biology, Philips Institute for Oral Health Research, VCU School of Dentistry and Massey Cancer Center, Virginia Commonwealth University, Richmond, VA 23298, USA., Floros KV; Department of Oral and Craniofacial Molecular Biology, Philips Institute for Oral Health Research, VCU School of Dentistry and Massey Cancer Center, Virginia Commonwealth University, Richmond, VA 23298, USA., Yu AK; Department of Oral and Craniofacial Molecular Biology, Philips Institute for Oral Health Research, VCU School of Dentistry and Massey Cancer Center, Virginia Commonwealth University, Richmond, VA 23298, USA., Coon CM; Department of Oral and Craniofacial Molecular Biology, Philips Institute for Oral Health Research, VCU School of Dentistry and Massey Cancer Center, Virginia Commonwealth University, Richmond, VA 23298, USA., Khatri R; Department of Oral and Craniofacial Molecular Biology, Philips Institute for Oral Health Research, VCU School of Dentistry and Massey Cancer Center, Virginia Commonwealth University, Richmond, VA 23298, USA., Alzubi MA; Department of Pathology, Virginia Commonwealth University School of Medicine, Richmond, VA 23298, USA.; Integrative Life Sciences Program, Virginia Commonwealth University, Richmond, VA 23298, USA., Jakubik CT; Center for Cancer Research, Massachusetts General Hospital Cancer Center and Department of Medicine, Harvard Medical School, Boston, MA 02129, USA., Bouck YM; Department of Oral and Craniofacial Molecular Biology, Philips Institute for Oral Health Research, VCU School of Dentistry and Massey Cancer Center, Virginia Commonwealth University, Richmond, VA 23298, USA., Puchalapalli M; Department of Pathology, Virginia Commonwealth University School of Medicine, Richmond, VA 23298, USA., Shende M; Department of Pathology, Virginia Commonwealth University School of Medicine, Richmond, VA 23298, USA., Dozmorov MG; Department of Biostatistics, Virginia Commonwealth University, Richmond, VA 23298, USA., Boikos SA; Hematology, Oncology and Palliative Care, School of Medicine and Massey Cancer Center, Virginia Commonwealth University, Richmond, VA 23298, USA., Hu B; Department of Pathology, Virginia Commonwealth University School of Medicine, Richmond, VA 23298, USA., Harrell JC; Department of Pathology, Virginia Commonwealth University School of Medicine, Richmond, VA 23298, USA.; Wright Center for Clinical and Translational Research, Virginia Commonwealth University School of Medicine, Richmond, VA 23298, USA.; Integrative Life Sciences Program, Virginia Commonwealth University, Richmond, VA 23298, USA., Benes CH; Center for Cancer Research, Massachusetts General Hospital Cancer Center and Department of Medicine, Harvard Medical School, Boston, MA 02129, USA., Koblinski JE; Department of Pathology, Virginia Commonwealth University School of Medicine, Richmond, VA 23298, USA., Costa C; Center for Cancer Research, Massachusetts General Hospital Cancer Center and Department of Medicine, Harvard Medical School, Boston, MA 02129, USA., Faber AC; Department of Oral and Craniofacial Molecular Biology, Philips Institute for Oral Health Research, VCU School of Dentistry and Massey Cancer Center, Virginia Commonwealth University, Richmond, VA 23298, USA.

Publikováno v: PNAS nexus [PNAS Nexus] 2022 Oct 11; Vol. 1 (5), pp. pgac232. Date of Electronic Publication: 2022 Oct 11 (Print Publication: 2022).