Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Cookson K. C. Chiu"'
Spatiotemporal-resolved protein networks profiling with photoactivation dependent proximity labeling
Autor:
Yansheng Zhai, Xiaoyan Huang, Keren Zhang, Yuchen Huang, Yanlong Jiang, Jingwei Cui, Zhe Zhang, Cookson K. C. Chiu, Weiye Zhong, Gang Li
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-12 (2022)
Methods to identify protein interaction networks often suffer from poor spatiotemporal resolution. Here the authors present a light-activated proximity labeling method where the protein of interest is fused to the photosensitizer protein miniSOG, all
Externí odkaz:
https://doaj.org/article/02955cce232c437cb11554572b2a401a
Autor:
Carlos Sanchez-Cano, Cookson K. C. Chiu, Steven W. Magennis, Russell J. Needham, Peter J. Sadler, Raul Berrocal‐Martin
Publikováno v:
Chemistry – A European Journal. 26:4980-4987
The metallation of nucleic acids is key to wide‐ranging applications, from anticancer medicine to nanomaterials, yet there is a lack of understanding of the molecular‐level effects of metallation. Here, we apply single‐molecule fluorescence met
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9db83c8451957dcac2a57a61c8fdb6cd
https://doi.org/10.1002/chem.202000458
https://doi.org/10.1002/chem.202000458
Autor:
Peter J. Sadler, Cookson K. C. Chiu, Yuko P. Y. Lam, Peter B. O’Connor, Christopher A. Wootton, Mark P. Barrow
Publikováno v:
Journal of the American Society for Mass Spectrometry. 31(3)
The OsII arene anticancer complex [(η6-bip)Os(en)Cl]+ (Os1-Cl; where bip = biphenyl and en = ethylenediamine) binds strongly to DNA1 and biomolecules. Here we investigate the interaction between Os1-Cl and the model protein, BSA, using ultrahigh res
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::796c255991c1405e4187327af8a76b85
https://pubmed.ncbi.nlm.nih.gov/31967804
https://pubmed.ncbi.nlm.nih.gov/31967804
Autor:
Ian Hands-Portman, Cookson K. C. Chiu, Yuko P. Y. Lam, Frederik Lermyte, Juan Wei, Christopher A. Wootton, Isolda Romero-Canelón, Mark P. Barrow, Peter B. O’Connor
Publikováno v:
Journal of the American Society for Mass Spectrometry
Amyloid fibril formation is a hallmark in a range of human diseases. Analysis of the molecular details of amyloid aggregation, however, is limited by the difficulties in solubilizing, separating, and identifying the aggregated biomolecules. Additiona
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8d4e8d0ebf46e420e94dc8a3bed0c70
https://pubmed.ncbi.nlm.nih.gov/31922736
https://pubmed.ncbi.nlm.nih.gov/31922736
Autor:
Peter J. Sadler, Peter B. O’Connor, Mark P. Barrow, Guy J. Clarkson, Christopher A. Wootton, Andrea F. Lopez-Clavijo, Cookson K. C. Chiu, Adam J. Millett
Publikováno v:
The Analyst. 144(5)
The most widely used anticancer drugs are platinum complexes, but complexes of other transition metals also show promise and may widen the spectrum of activity, reduce side-effects, and overcome resistance. The latter include organo-iridium(III) ‘p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d9f5af2533d5c7a3a21926a1242d13a
https://pubmed.ncbi.nlm.nih.gov/30663751
https://pubmed.ncbi.nlm.nih.gov/30663751
Autor:
Peter J. Sadler, Carlos Sanchez-Cano, Cookson K. C. Chiu, Raul Berrocal‐Martin, Steven W. Magennis, Russell J. Needham
Publikováno v:
Chemistry – A European Journal. 26:4882-4882
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4d3d4bec3c307d99890e45834f2b18fe
https://doi.org/10.1002/chem.202000769
https://doi.org/10.1002/chem.202000769
Autor:
Frederik Lermyte, Ian Hands-Portman, Peter B. O’Connor, Yuko P. Y. Lam, Juan Wei, Christopher A. Wootton, Isolda Romero-Canelón, Cookson K. C. Chiu, Mark P. Barrow
Publikováno v:
Chemical communications (Cambridge, England). 54(98)
Mass spectrometry has been applied to determine the deamidation sites and the aggregation region of the deamidated human islet amyloid polypeptide (hIAPP). Mutant hIAPP with iso-aspartic residue mutations at possible deamidation sites showed very dif
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd150dd3dc734307ed68724ddcad8c7d
https://pubmed.ncbi.nlm.nih.gov/30474090
https://pubmed.ncbi.nlm.nih.gov/30474090
Autor:
Martin Wills, Peter B. O′ Connor, Cookson K. C. Chiu, Lavrentis-Demetrios Galanopoulos, Guy J. Clarkson, Alessandro Del Grosso
Publikováno v:
Organicbiomolecular chemistry. 15(21)
A series of strained alkynes were prepared from 2,2′-dihydroxy-biaryls. Several were characterised by X-ray crystallography, revealing strained C(sp)–C(sp)–C(sp3) bond angles in the range of 163–167°. Their cycloadditions with azides proceed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35b32a25d46fc886365aebb2004ea6ee
https://pubmed.ncbi.nlm.nih.gov/28513734
https://pubmed.ncbi.nlm.nih.gov/28513734
Autor:
Thomas Malcomson, Guy J. Clarkson, Cookson K. C. Chiu, Yuko P. Y. Lam, Pingyu Zhang, Abraha Habtemariam, Martin J. Paterson, Peter B. O’Connor, Huaiyi Huang, Hui Chao, Peter J. Sadler
Publikováno v:
Angewandte Chemie. 129:14968-14968
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a0366fc56986489c333f069fbfce5cb2
https://doi.org/10.1002/ange.201710973
https://doi.org/10.1002/ange.201710973
Autor:
Thomas Malcomson, Cookson K. C. Chiu, Abraha Habtemariam, Hui Chao, Peter B. O’Connor, Huaiyi Huang, Pingyu Zhang, Guy J. Clarkson, Yuko P. Y. Lam, Peter J. Sadler, Martin J. Paterson
Publikováno v:
Angewandte Chemie International Edition. 56:14774-14774
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6e6c48564354baaf6620d82121ebd9bc
https://doi.org/10.1002/anie.201710973
https://doi.org/10.1002/anie.201710973