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Elucidation of the genetic causes of bicuspid aortic valve disease.

Autor: Gehlen J; Institute of Human Genetics, University of Bonn and University Hospital Bonn, Bonn, Germany.; Institute of Human Genetics, Philipps University of Marburg, Marburg, Germany., Stundl A; Department of Medicine II, Heart Center Bonn, University of Bonn and University Hospital Bonn, Bonn, Germany.; Klinik und Poliklinik für Innere Medizin I, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany.; DZHK (German Center for Cardiovascular Research), Partner Site Munich Heart Alliance, Munich, Germany., Debiec R; Department of Cardiovascular Sciences, University of Leicester, Leicester, UK.; NIHR Leicester Biomedical Research Centre, Glenfield Hospital, Leicester, UK.; East Midlands Congenital Heart Centre, Glenfield Hospital, Leicester, UK., Fontana F; Institute of Biochemistry and Biology, Potsdam University, Potsdam, Germany., Krane M; DZHK (German Center for Cardiovascular Research), Partner Site Munich Heart Alliance, Munich, Germany.; Division of Experimental Surgery, Department of Cardiovascular Surgery, Institute Insure, German Heart Center Munich, TUM School of Medicine, Technical University of Munich, Munich, Germany.; Division of Cardiac Surgery, Department of Surgery, Yale University School of Medicine, New Haven, CT, USA., Sharipova D; Institute of Biochemistry and Biology, Potsdam University, Potsdam, Germany., Nelson CP; Department of Cardiovascular Sciences, University of Leicester, Leicester, UK.; NIHR Leicester Biomedical Research Centre, Glenfield Hospital, Leicester, UK., Al-Kassou B; Department of Medicine II, Heart Center Bonn, University of Bonn and University Hospital Bonn, Bonn, Germany., Giel AS; Institute of Human Genetics, Philipps University of Marburg, Marburg, Germany., Sinning JM; Department of Medicine II, Heart Center Bonn, University of Bonn and University Hospital Bonn, Bonn, Germany., Bruenger CMH; Institute of Human Genetics, Philipps University of Marburg, Marburg, Germany., Zelck CF; Institute of Human Genetics, Philipps University of Marburg, Marburg, Germany., Koebbe LL; Institute of Human Genetics, Philipps University of Marburg, Marburg, Germany., Braund PS; Department of Cardiovascular Sciences, University of Leicester, Leicester, UK.; NIHR Leicester Biomedical Research Centre, Glenfield Hospital, Leicester, UK., Webb TR; Department of Cardiovascular Sciences, University of Leicester, Leicester, UK.; NIHR Leicester Biomedical Research Centre, Glenfield Hospital, Leicester, UK., Hetherington S; Kettering General Hospital NHS Foundation Trust, Kettering, UK., Ensminger S; Department of Cardiac and Thoracic Vascular Surgery, University Heart Center Lübeck, University Hospital of Schleswig-Holstein, Lübeck, Germany.; DZHK (German Centre for Cardiovascular Research), Partner Site Hamburg/Kiel/Lübeck, Lübeck, Germany., Fujita B; Department of Cardiac and Thoracic Vascular Surgery, University Heart Center Lübeck, University Hospital of Schleswig-Holstein, Lübeck, Germany.; DZHK (German Centre for Cardiovascular Research), Partner Site Hamburg/Kiel/Lübeck, Lübeck, Germany., Mohamed SA; Department of Cardiac and Thoracic Vascular Surgery, University Heart Center Lübeck, University Hospital of Schleswig-Holstein, Lübeck, Germany.; DZHK (German Centre for Cardiovascular Research), Partner Site Hamburg/Kiel/Lübeck, Lübeck, Germany., Shrestha M; Department of Adult and Pediatric Cardiothoracic Surgery, Vascular Surgery, Heart and Lung Transplantation, Hannover Medical School, Hannover, Germany., Krueger H; Department of Adult and Pediatric Cardiothoracic Surgery, Vascular Surgery, Heart and Lung Transplantation, Hannover Medical School, Hannover, Germany., Siepe M; Heart Center Freiburg/Bad Krozingen, University Freiburg/Bad Krozingen, Freiburg, Germany., Kari FA; Heart Center Freiburg/Bad Krozingen, University Freiburg/Bad Krozingen, Freiburg, Germany., Nordbeck P; Medizinische Klinik und Poliklinik I, University Hospital Würzburg, Würzburg, Germany., Buravezky L; Medizinische Klinik und Poliklinik I, University Hospital Würzburg, Würzburg, Germany., Kelm M; Department of Cardiology, Pneumology and Angiology, University Hospital Duesseldorf, Duesseldorf, Germany., Veulemans V; Department of Cardiology, Pneumology and Angiology, University Hospital Duesseldorf, Duesseldorf, Germany., Adam M; Department of Medicine III, Heart Center Cologne, University Hospital Cologne, Cologne, Germany., Baldus S; Department of Medicine III, Heart Center Cologne, University Hospital Cologne, Cologne, Germany., Laugwitz KL; Klinik und Poliklinik für Innere Medizin I, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany.; DZHK (German Center for Cardiovascular Research), Partner Site Munich Heart Alliance, Munich, Germany., Haas Y; Klinik und Poliklinik für Innere Medizin I, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany., Karck M; Department of Cardiothoracic Surgery, University Hospital Heidelberg, Heidelberg, Germany., Mehlhorn U; Department of Cardiothoracic Surgery, Helios Klinik Karlsruhe, Karlsruhe, Germany., Conzelmann LO; Department of Cardiothoracic Surgery, Helios Klinik Karlsruhe, Karlsruhe, Germany., Breitenbach I; Department of Cardiothoracic Surgery and Vascular Surgery, Clinic of Braunschweig, Braunschweig, Germany., Lebherz C; Department of Medicine I, Cardiology/Angiology/Intensive Care, University Hospital Aachen, Aachen, Germany., Urbanski P; Department of Cardiovascular Surgery, Cardiovascular Clinic, Rhön-Klinikum Campus Bad Neustadt, Neustadt, Germany., Kim WK; Department of Cardiology, Heart Center, Kerckhoff Clinic, Bad Nauheim, Germany., Kandels J; Department of Cardiology, University Hospital Leipzig, Leipzig, Germany., Ellinghaus D; Institute of Clinical Molecular Biology, Christian-Albrechts-University of Kiel, Kiel, Germany.; Novo Nordisk Foundation Center for Protein Research, Disease Systems Biology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Nowak-Goettl U; Department of Clinical Chemistry, Thrombosis and Hemostasis Unit, University Hospital of Kiel and Lübeck, Kiel, Germany., Hoffmann P; Institute of Human Genetics, University of Bonn and University Hospital Bonn, Bonn, Germany., Wirth F; Division of Experimental Surgery, Department of Cardiovascular Surgery, Institute Insure, German Heart Center Munich, TUM School of Medicine, Technical University of Munich, Munich, Germany., Doppler S; Division of Experimental Surgery, Department of Cardiovascular Surgery, Institute Insure, German Heart Center Munich, TUM School of Medicine, Technical University of Munich, Munich, Germany., Lahm H; Division of Experimental Surgery, Department of Cardiovascular Surgery, Institute Insure, German Heart Center Munich, TUM School of Medicine, Technical University of Munich, Munich, Germany., Dreßen M; Division of Experimental Surgery, Department of Cardiovascular Surgery, Institute Insure, German Heart Center Munich, TUM School of Medicine, Technical University of Munich, Munich, Germany., von Scheidt M; DZHK (German Center for Cardiovascular Research), Partner Site Munich Heart Alliance, Munich, Germany.; Department of Cardiology, German Heart Centre Munich, Technical University of Munich, Munich, Germany., Knoll K; DZHK (German Center for Cardiovascular Research), Partner Site Munich Heart Alliance, Munich, Germany.; Department of Cardiology, German Heart Centre Munich, Technical University of Munich, Munich, Germany., Kessler T; DZHK (German Center for Cardiovascular Research), Partner Site Munich Heart Alliance, Munich, Germany.; Department of Cardiology, German Heart Centre Munich, Technical University of Munich, Munich, Germany., Hengstenberg C; Division of Cardiology, Department of Internal Medicine II, Medical University of Vienna, Vienna, Austria., Schunkert H; DZHK (German Center for Cardiovascular Research), Partner Site Munich Heart Alliance, Munich, Germany.; Department of Cardiology, German Heart Centre Munich, Technical University of Munich, Munich, Germany., Nickenig G; Department of Medicine II, Heart Center Bonn, University of Bonn and University Hospital Bonn, Bonn, Germany., Nöthen MM; Institute of Human Genetics, University of Bonn and University Hospital Bonn, Bonn, Germany., Bolger AP; NIHR Leicester Biomedical Research Centre, Glenfield Hospital, Leicester, UK.; East Midlands Congenital Heart Centre, Glenfield Hospital, Leicester, UK.; Institute of Biochemistry and Biology, Potsdam University, Potsdam, Germany., Abdelilah-Seyfried S; Institute of Biochemistry and Biology, Potsdam University, Potsdam, Germany.; Institute of Molecular Biology, Hannover Medical School, Hannover, Germany., Samani NJ; Department of Cardiovascular Sciences, University of Leicester, Leicester, UK.; NIHR Leicester Biomedical Research Centre, Glenfield Hospital, Leicester, UK., Erdmann J; DZHK (German Centre for Cardiovascular Research), Partner Site Hamburg/Kiel/Lübeck, Lübeck, Germany.; Institute for Cardiogenetics, University Heart Centre Lübeck, University of Lübeck, Lübeck, Germany., Trenkwalder T; DZHK (German Center for Cardiovascular Research), Partner Site Munich Heart Alliance, Munich, Germany.; Department of Cardiology, German Heart Centre Munich, Technical University of Munich, Munich, Germany., Schumacher J; Institute of Human Genetics, University of Bonn and University Hospital Bonn, Bonn, Germany.; Institute of Human Genetics, Philipps University of Marburg, Marburg, Germany.

Publikováno v: Cardiovascular research [Cardiovasc Res] 2023 May 02; Vol. 119 (3), pp. 857-866.