Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Conxita Jacobs-Cachá"'
Autor:
Nerea Martos-Guillami, Ander Vergara, Carmen Llorens-Cebrià, Aku Enam Motto, Irene Martínez-Díaz, Francisco Gonçalves, Maria Magdalena Garcias-Ramis, Estibaliz Allo-Urzainqui, Alonso Narváez, Sheila Bermejo, Vicent Muñoz, Juan León-Román, Roser Ferrer-Costa, Conxita Jacobs-Cachá, Jordi Vilardell-Vilà, María José Soler
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
IntroductionDiabetic Kidney Disease (DKD) is the main cause of end-stage renal disease in the developed world. The current treatment of the DKD with renin-angiotensin system (RAS) blockade does not totally halt the progression to end stage kidney dis
Externí odkaz:
https://doaj.org/article/7e319ae57f3040b09b2c9a304b365834
Autor:
Irene Martínez-Díaz, Nerea Martos, Carmen Llorens-Cebrià, Francisco J. Álvarez, Patricia W. Bedard, Ander Vergara, Conxita Jacobs-Cachá, Maria José Soler
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 4, p 3427 (2023)
Endothelin (ET) is found to be increased in kidney disease secondary to hyperglycaemia, hypertension, acidosis, and the presence of insulin or proinflammatory cytokines. In this context, ET, via the endothelin receptor type A (ETA) activation, causes
Externí odkaz:
https://doaj.org/article/25d2a4b82b8746859952b6ee455af496
Autor:
Carmen Llorens-Cebrià, Mireia Molina-Van den Bosch, Ander Vergara, Conxita Jacobs-Cachá, Maria José Soler
Publikováno v:
Biomolecules, Vol 12, Iss 1, p 143 (2022)
The reduction-oxidation (redox) system consists of the coupling and coordination of various electron gradients that are generated thanks to serial reduction-oxidation enzymatic reactions. These reactions happen in every cell and produce radical oxida
Externí odkaz:
https://doaj.org/article/81a8e70612294f4ab53e47dc775db807
Autor:
Anna Giralt-López, Mireia Molina-Van den Bosch, Ander Vergara, Clara García-Carro, Daniel Seron, Conxita Jacobs-Cachá, Maria José Soler
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 10, p 3587 (2020)
Diabetes prevalence is constantly increasing and, nowadays, it affects more than 350 million people worldwide. Therefore, the prevalence of diabetic nephropathy (DN) has also increased, becoming the main cause of end-stage renal disease (ESRD) in the
Externí odkaz:
https://doaj.org/article/a1c4b684159342db897bd23d0a9e7489
Publikováno v:
Hipertensión y Riesgo Vascular. 38:125-132
The renin-angiotensin-aldosterone (RAAS) system and its effects on blood pressure and the regulation of water and electrolyte balance have been studied focusing on the cardiovascular and renal system. The activation of RAAS in other organs has local
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c967211a8bb9c90b846803c59824ddc0
https://doi.org/10.1016/j.hipert.2020.12.001
https://doi.org/10.1016/j.hipert.2020.12.001
Autor:
Maria Dolores Sanchez-Niño, María José Soler, Conxita Jacobs-Cachá, Roman D. Bülow, Reinhard E. Voll, Peter Boor, Yutian Lei, Bettina Sehnert, Alberto Ortiz, Hans-Joachim Anders
Publikováno v:
Kidney International. 99:1331-1341
Data reproducibility and single-center bias are concerns in preclinical research and compromise translation from animal to human. Multicenter preclinical randomized controlled trials (pRCT) may reduce the gap between experimental studies and RCT and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a806159284230f0b986fe83c57924b59
https://doi.org/10.1016/j.kint.2021.01.024
https://doi.org/10.1016/j.kint.2021.01.024
Autor:
Ander Vergara, Carmen Llorens-Cebrià, Nerea Martos, Irene Martínez-Díaz, Frank Stein, Pamela Domínguez-Báez, Mireia Molina-Van den Bosch, Mandy Rettel, Begoña Benito, Sheila Bermejo, Michael Paul Pieper, Conxita Jacobs-Cachá, Maria José Soler
Publikováno v:
Clinical science (London, England : 1979). 137(1)
Sodium-glucose cotransporter 2 inhibitors (SGLT2i) have proven to delay diabetic kidney disease (DKD) progression on top of the standard of care with the renin–angiotensin system (RAS) blockade. The molecular mechanisms underlying the synergistic e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56eaf16affe8948925ec091f381d9068
https://pubmed.ncbi.nlm.nih.gov/36524468
https://pubmed.ncbi.nlm.nih.gov/36524468
Autor:
Conxita Jacobs Cachá, Maria Martín-Agramunt, Maria Gema Ariceta Iraola, Juan Carlos Leon, Mercedes López, Natalia Ramos Terrada, Marina Muñoz, Irene Agraz, Maria José Soler Romeo, Manuel Hernández-González
Publikováno v:
Nephrology Dialysis Transplantation. 37
BACKGROUND AND AIMS The atypical hemolytic uremic syndrome (aHUS) is a complement-mediated (CM) ultrarare disease that manifests as thrombotic microangiopathy (TMA) with preferential small kidney vessels involvement. aHUS is caused by genetic or acqu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::225454b87fcb745e5b05462026ad50bd
https://doi.org/10.1093/ndt/gfac063.025
https://doi.org/10.1093/ndt/gfac063.025
Autor:
Carmen Llorens Cebrià, Monica Durán, Mireia Molina Van den Bosch, Pamela Dominguez, Yolanda Villena, Gerard Cantero Recasens, Maria José Soler Romeo, Joan López Hellín, Conxita Jacobs Cachá
Publikováno v:
Nephrology Dialysis Transplantation. 37
BACKGROUND AND AIMS Renal proximal tubule epithelial cells (RPTECs) are responsible for solute and protein reabsorption. It has been described that the human RPTEC/TERT1 cell line expresses several transporters, including the cubilin–amnionless–m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9eada0aba8be680daf5f6f953fd63b43
https://doi.org/10.1093/ndt/gfac060.003
https://doi.org/10.1093/ndt/gfac060.003
Autor:
Ander Vergara Arana, Conxita Jacobs Cachá, Mireia Molina, Carmen Llorens Cebrià, Pamela Dominguez, Sheila Bermejo, Michael Paul Pieper, Begoña Benito, Maria Jose Soler Romeo
Publikováno v:
Nephrology Dialysis Transplantation. 37
BACKGROUND AND AIMS sodium-glucose 2 cotransporter inhibitors (SGLT2i) prevent cardiovascular events in diabetic patients. Moreover, their diuretic effect could attenuate the adverse events of endothelin receptor antagonists (ERA), which have also sh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b0961b1e9ee5fcd4b9f11f77b10bc902
https://doi.org/10.1093/ndt/gfac125.003
https://doi.org/10.1093/ndt/gfac125.003