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Age-Associated Contraction of Tumor-Specific T Cells Impairs Antitumor Immunity.

Autor: Georgiev P; Department of Immunology, Blavatnik Institute, Harvard Medical School, Boston, Massachusetts.; Department of Cell Biology, Blavatnik Institute, Harvard Medical School, Boston, Massachusetts.; Gene Lay Institute of Immunology and Inflammation of Brigham and Women's Hospital, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts., Han S; Department of Immunology, Blavatnik Institute, Harvard Medical School, Boston, Massachusetts.; Department of Cell Biology, Blavatnik Institute, Harvard Medical School, Boston, Massachusetts.; Gene Lay Institute of Immunology and Inflammation of Brigham and Women's Hospital, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts., Huang AY; Department of Immunology, Blavatnik Institute, Harvard Medical School, Boston, Massachusetts.; Gene Lay Institute of Immunology and Inflammation of Brigham and Women's Hospital, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts.; Division of Population Sciences, Dana-Farber Cancer Institute, Boston, Massachusetts., Nguyen TH; Department of Immunology, Blavatnik Institute, Harvard Medical School, Boston, Massachusetts.; Gene Lay Institute of Immunology and Inflammation of Brigham and Women's Hospital, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts., Drijvers JM; Department of Immunology, Blavatnik Institute, Harvard Medical School, Boston, Massachusetts.; Department of Cell Biology, Blavatnik Institute, Harvard Medical School, Boston, Massachusetts.; Gene Lay Institute of Immunology and Inflammation of Brigham and Women's Hospital, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts., Creasey H; Department of Immunology, Blavatnik Institute, Harvard Medical School, Boston, Massachusetts.; Gene Lay Institute of Immunology and Inflammation of Brigham and Women's Hospital, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts., Pereira JA; Department of Immunology, Blavatnik Institute, Harvard Medical School, Boston, Massachusetts.; Gene Lay Institute of Immunology and Inflammation of Brigham and Women's Hospital, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts., Yao CH; Department of Cell Biology, Blavatnik Institute, Harvard Medical School, Boston, Massachusetts.; Gene Lay Institute of Immunology and Inflammation of Brigham and Women's Hospital, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts., Park JS; Department of Immunology, Blavatnik Institute, Harvard Medical School, Boston, Massachusetts.; Gene Lay Institute of Immunology and Inflammation of Brigham and Women's Hospital, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts., Conway TS; Department of Immunology, Blavatnik Institute, Harvard Medical School, Boston, Massachusetts.; Gene Lay Institute of Immunology and Inflammation of Brigham and Women's Hospital, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts., Fung ME; Department of Immunology, Blavatnik Institute, Harvard Medical School, Boston, Massachusetts.; Gene Lay Institute of Immunology and Inflammation of Brigham and Women's Hospital, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts., Liang D; Department of Immunology, Blavatnik Institute, Harvard Medical School, Boston, Massachusetts.; Gene Lay Institute of Immunology and Inflammation of Brigham and Women's Hospital, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts., Peluso M; Department of Immunology, Blavatnik Institute, Harvard Medical School, Boston, Massachusetts.; Gene Lay Institute of Immunology and Inflammation of Brigham and Women's Hospital, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts., Joshi S; Department of Cell Biology, Blavatnik Institute, Harvard Medical School, Boston, Massachusetts.; Gene Lay Institute of Immunology and Inflammation of Brigham and Women's Hospital, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts., Rowe JH; Department of Immunology, Blavatnik Institute, Harvard Medical School, Boston, Massachusetts.; Department of Cell Biology, Blavatnik Institute, Harvard Medical School, Boston, Massachusetts.; Gene Lay Institute of Immunology and Inflammation of Brigham and Women's Hospital, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts.; Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts., Miller BC; Division of Oncology, Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.; Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.; Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina., Freeman GJ; Department of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, Massachusetts., Sharpe AH; Department of Immunology, Blavatnik Institute, Harvard Medical School, Boston, Massachusetts.; Gene Lay Institute of Immunology and Inflammation of Brigham and Women's Hospital, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts., Haigis MC; Department of Cell Biology, Blavatnik Institute, Harvard Medical School, Boston, Massachusetts.; Gene Lay Institute of Immunology and Inflammation of Brigham and Women's Hospital, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts., Ringel AE; Ragon Institute of Mass General, MIT, and Harvard, Cambridge, Massachusetts.; Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts.; David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts.

Publikováno v: Cancer immunology research [Cancer Immunol Res] 2024 Nov 04; Vol. 12 (11), pp. 1525-1541.