Direct activation of KCC2 arrests benzodiazepine refractory status epilepticus and limits the subsequent neuronal injury in mice.

Autor: Jarvis R; Discovery, Neuroscience, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK., Josephine Ng SF; Department of Neuroscience, Tufts University School of Medicine, 136 Harrison Avenue, Boston, MA 02111, USA., Nathanson AJ; Department of Neuroscience, Tufts University School of Medicine, 136 Harrison Avenue, Boston, MA 02111, USA., Cardarelli RA; Department of Neuroscience, Tufts University School of Medicine, 136 Harrison Avenue, Boston, MA 02111, USA., Abiraman K; Department of Neuroscience, Tufts University School of Medicine, 136 Harrison Avenue, Boston, MA 02111, USA., Wade F; Department of Neuroscience, Tufts University School of Medicine, 136 Harrison Avenue, Boston, MA 02111, USA., Evans-Strong A; Department of Neuroscience, Tufts University School of Medicine, 136 Harrison Avenue, Boston, MA 02111, USA., Fernandez-Campa MP; Department of Neuroscience, Tufts University School of Medicine, 136 Harrison Avenue, Boston, MA 02111, USA., Deeb TZ; Department of Neuroscience, Tufts University School of Medicine, 136 Harrison Avenue, Boston, MA 02111, USA., Smalley JL; Department of Neuroscience, Tufts University School of Medicine, 136 Harrison Avenue, Boston, MA 02111, USA., Jamier T; Discovery, Neuroscience, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK., Gurrell IK; Discovery, Neuroscience, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK., McWilliams L; Discovery Biology, Discovery Sciences, R&D, AstraZeneca, Cambridge, UK., Kawatkar A; Discovery Biology, Discovery Sciences, R&D, AstraZeneca, Boston, MA, USA., Conway LC; Department of Neuroscience, Tufts University School of Medicine, 136 Harrison Avenue, Boston, MA 02111, USA., Wang Q; Discovery, Neuroscience, BioPharmaceuticals R&D, AstraZeneca, Boston, MA, USA., Burli RW; Discovery, Neuroscience, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK., Brandon NJ; Discovery, Neuroscience, BioPharmaceuticals R&D, AstraZeneca, Boston, MA, USA., Chessell IP; Discovery, Neuroscience, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK., Goldman AJ; Department of Medicine, Harvard Medical School, Boston, MA 02115, USA., Maguire JL; Department of Neuroscience, Tufts University School of Medicine, 136 Harrison Avenue, Boston, MA 02111, USA., Moss SJ; Department of Neuroscience, Tufts University School of Medicine, 136 Harrison Avenue, Boston, MA 02111, USA; Department of Neuroscience, Physiology and Pharmacology, University College London, London WC1 6BT, UK. Electronic address: stephen.moss@tufts.edu.

Publikováno v: Cell reports. Medicine [Cell Rep Med] 2023 Mar 21; Vol. 4 (3), pp. 100957. Date of Electronic Publication: 2023 Mar 07.

Developmental Regulation of KCC2 Phosphorylation Has Long-Term Impacts on Cognitive Function.

Autor: Moore YE; Department of Neuroscience, Tufts University School of Medicine, Boston, MA, United States., Conway LC; AstraZeneca-Tufts University Laboratory for Basic and Translational Neuroscience Research, Tufts University School of Medicine, Boston, MA, United States., Wobst HJ; Neuroscience, R&D Biopharmaceuticals, AstraZeneca, Boston, MA, United States., Brandon NJ; Neuroscience, R&D Biopharmaceuticals, AstraZeneca, Boston, MA, United States., Deeb TZ; Department of Neuroscience, Tufts University School of Medicine, Boston, MA, United States., Moss SJ; Department of Neuroscience, Tufts University School of Medicine, Boston, MA, United States.; AstraZeneca-Tufts University Laboratory for Basic and Translational Neuroscience Research, Tufts University School of Medicine, Boston, MA, United States.; Department of Neuroscience, Physiology and Pharmacology, University College London, London, United Kingdom.

Publikováno v: Frontiers in molecular neuroscience [Front Mol Neurosci] 2019 Jul 23; Vol. 12, pp. 173. Date of Electronic Publication: 2019 Jul 23 (Print Publication: 2019).

Molecular architecture of potassium chloride co-transporter KCC2.

Autor: Agez M; CALIXAR, 60 avenue Rockefeller, 69008, Lyon, France., Schultz P; Department of Integrated Structural Biology, IGBMC (Institut de Génétique et de Biologie Moléculaire et Cellulaire) INSERM, U964; CNRS/Strasbourg University, UMR7104 1, rue Laurent Fries, BP10142, 67404, Illkirch, France., Medina I; INMED, INSERM Unité 901, Marseille, France., Baker DJ; Discovery Sciences, IMED Biotech Unit, AstraZeneca, Cambridge, UK., Burnham MP; Discovery Sciences, IMED Biotech Unit, AstraZeneca, Alderley Park, UK., Cardarelli RA; AstraZeneca Tufts Laboratory for Basic and Translational Neuroscience, Boston, Massachusetts, 02111, USA., Conway LC; AstraZeneca Tufts Laboratory for Basic and Translational Neuroscience, Boston, Massachusetts, 02111, USA., Garnier K; CALIXAR, 60 avenue Rockefeller, 69008, Lyon, France., Geschwindner S; Discovery Sciences, IMED Biotech Unit, AstraZeneca, Gothenburg, Sweden., Gunnarsson A; Discovery Sciences, IMED Biotech Unit, AstraZeneca, Gothenburg, Sweden., McCall EJ; Discovery Sciences, IMED Biotech Unit, AstraZeneca, Cambridge, UK., Frechard A; Department of Integrated Structural Biology, IGBMC (Institut de Génétique et de Biologie Moléculaire et Cellulaire) INSERM, U964; CNRS/Strasbourg University, UMR7104 1, rue Laurent Fries, BP10142, 67404, Illkirch, France., Audebert S; Aix Marseille Univ, CNRS, INSERM, Institut Paoli-Calmettes, CRCM, Marseille Protéomique, Marseille, France., Deeb TZ; AstraZeneca Tufts Laboratory for Basic and Translational Neuroscience, Boston, Massachusetts, 02111, USA., Moss SJ; Department of Neuroscience, Tufts University School of Medicine, Boston, MA, 02111, USA.; Department of Neuroscience, Physiology and Pharmacology, University College, London, WC1E, 6BT, UK., Brandon NJ; AstraZeneca Tufts Laboratory for Basic and Translational Neuroscience, Boston, Massachusetts, 02111, USA.; Neuroscience, IMED Biotech Unit, AstraZeneca, Boston, MA, USA., Wang Q; AstraZeneca Tufts Laboratory for Basic and Translational Neuroscience, Boston, Massachusetts, 02111, USA.; Neuroscience, IMED Biotech Unit, AstraZeneca, Boston, MA, USA., Dekker N; Discovery Sciences, IMED Biotech Unit, AstraZeneca, Gothenburg, Sweden. niek.dekker@astrazeneca.com., Jawhari A; CALIXAR, 60 avenue Rockefeller, 69008, Lyon, France. ajawhari@calixar.com.

Publikováno v: Scientific reports [Sci Rep] 2017 Nov 28; Vol. 7 (1), pp. 16452. Date of Electronic Publication: 2017 Nov 28.

Readers' eye movements distinguish anomalies of form and content.

Autor: Braze D; University of Connecticut & Haskins Laboratories, New Haven, USA. dave.braze@uconn.edu, Shankweiler D, Ni W, Palumbo LC

Publikováno v: Journal of psycholinguistic research [J Psycholinguist Res] 2002 Jan; Vol. 31 (1), pp. 25-44.