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Akademický článek

Antiplatelet effects of the CEACAM1-derived peptide QDTT

Autor: Yujia Ye, Min Leng, Shengjie Chai, Lihong Yang, Longcheng Ren, Wen Wan, Huawei Wang, Longjun Li, Chaozhong Li, Zhaohui Meng

Publikováno v: Platelets, Vol 35, Iss 1 (2024)

AbstractCarcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) restricts platelet activation via platelet collagen receptor GPVI/FcRγ-chain. In this study, screening against collagen-induced platelet aggregation was performed to identif

Externí odkaz: https://doaj.org/article/d021f377c6d041e2b3c42c00288ed339

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Akademický článek

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A novel naphthalimide derivative reduces platelet activation and thrombus formation via suppressing GPVI

Autor: Wan-Jung Lu, Wei‐Ting Kao, Ting Yu Chen, Tzenge-Lien Shih, Ray-Jade Chen, Hsien-Yu Peng, Yu-Yo Sun, Jen-Wei Liu, Hsueh-Hsiao Wang, Kuan-Hung Lin

Publikováno v: Journal of Cellular and Molecular Medicine

Naphthalimide derivatives have multiple biological activities, including antitumour and anti‐inflammatory activities. We previously synthesized several naphthalimide derivatives; of them, compound 5 was found to exert the strongest inhibitory effec

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e679075a7a7439fcd5e4bfb197e2dc59
http://europepmc.org/articles/PMC8500964

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A fibrinolytic snake venom metalloproteinase, mutalysin-II, with antiplatelet activity and targeting capability toward glycoprotein GPIbα and glycoprotein GPVI

Autor: Johannes A. Eble, Luciana S. Oliveira, Maria Inácia Estevão-Costa, Valeria G. Alvarenga, Debora Priscila Larangote De Oliveira, Renzo Joel Flores-Ortiz, Eladio F. Sanchez

Publikováno v: Biochimie. 184:1-7

Glycoprotein (GP)Ib that binds von Willebrand factor (vWF) and glycoprotein (GP)VI, that binds collagen play a significant role in platelet activation and aggregation, and are potential targets for antithrombotic treatment. They are targeted by snake

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f618572767d00f5072fcde431efcea3
https://doi.org/10.1016/j.biochi.2021.01.016

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Inhibition of plasma kallikrein mitigates experimental hypertension-enhanced cerebral hematoma expansion

Autor: Weixiang Chen, Xiaoqin Tang, Xin Liu, Mingxi Li, Tunan Chen, Min Xia, Hua Feng, Zhengcai Jia, Chengcheng Li, Yi Yin, Jiantao Shi, Chao Guo, Jie Wang

Publikováno v: Brain Research Bulletin. 170:49-57

Rationale Hematoma expansion (HE) aggravates brain injury after intracerebral hemorrhage (ICH) and hypertension is a key contributor to HE. Plasma kallikrein (PK) is involved in hemorrhagic transformation in ischemic stroke mice. This study was condu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c80f12475c68dc0e143dd3ea972325df
https://doi.org/10.1016/j.brainresbull.2021.02.004

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High-Dose Epinephrine Enhances Platelet Aggregation at the Expense of Procoagulant Activity

Autor: Maxime G. Zermatten, Alessandro Aliotta, Lorenzo Alberio, Debora Bertaggia Calderara

Publikováno v: Thrombosis and Haemostasis. 121:1337-1344

Platelet activation is characterized by shape change, granule secretion, activation of fibrinogen receptor (glycoprotein IIb/IIIa) sustaining platelet aggregation, and externalization of negatively charged aminophospholipids contributing to platelet

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2666b6b889f88388f011919867ce6a9f
https://doi.org/10.1055/a-1420-7630

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Akademický článek

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Complementary roles of platelet αIIbβ3 integrin, phosphatidylserine exposure and cytoskeletal rearrangement in the release of extracellular vesicles

Autor: Johan W. M. Heemskerk, Rory R. Koenen, Alexandra C.A. Heinzmann, Tanja Vajen, Tilman M. Hackeng, Daniëlle Coenen, Judith M.E.M. Cosemans, Mieke F.A. Karel, Dennis Suylen, Nicole Meulendijks, Magdolna Nagy

Publikováno v: Atherosclerosis, 310, 17-25. Elsevier Ireland Ltd

Background and aims: Platelets can release extracellular vesicles (EVs) upon stimulation with various agonists. Interestingly, platelets from patients with Glanzmann thrombasthenia have reduced EV release. These platelets lack functional alpha(IIb)be

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d78d20943879dc28ab40d7aaf65bf623
https://doi.org/10.1016/j.atherosclerosis.2020.07.015

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Effect of Isolated Proteins from Crotalus Durissus Terrificus Venom on Leishmania (Leishmania) Amazonensis-Infected Macrophages

Autor: Clara Lúcia Barbiéri, Stella Regina Zamuner, Simone Katz, Maria Cristina Chavantes, Fernanda Paula Martins Soler, Andreimar Martins Soares

Publikováno v: Protein & Peptide Letters. 27:718-724

Background: Cutaneous and mucocutaneous leishmaniasis are parasitic diseases characterized by skin manifestations. In Brazil, Leishmania (Leishmania) amazonensis is one of the etiological agents of cutaneous leishmaniasis. The therapeutic arsenal rou

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e99ee5be4a8e19dadb503cd6cf4e0a36
https://doi.org/10.2174/0929866527666200129152954

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D-Dimer and Fibrin Degradation Products Impair Platelet Signaling: Plasma D-Dimer Is a Predictor and Mediator of Platelet Dysfunction During Trauma

Autor: Christopher C. Verni, Carrie A. Sims, Scott L. Diamond, Antonio Davila

Publikováno v: J Appl Lab Med

Background Platelet dysfunction often accompanies trauma-induced coagulopathy. Because soluble fibrin impairs platelet glycoprotein VI (GPVI) signaling and platelets of trauma patients can display impaired calcium mobilization, we explored the role o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e3dfa5df0893208d9c3feffa0e31bfa
https://doi.org/10.1093/jalm/jfaa047

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