Animal Venom Peptides Cause Antinociceptive Effects by Voltage-gated Calcium Channels Activity Blockage

Autor: Sara Marchesan Oliveira, Gabriela Trevisan

Publikováno v: Current Neuropharmacology. 20:1579-1599

Pain is a complex phenomenon that is usually unpleasant and aversive. It can range widely in intensity, quality, and duration and has diverse pathophysiologic mechanisms and meanings. Voltage-gated sodium and calcium channels are essential to transmi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6cee0f09f5edcc7c6d8e0dd43c36b9e5
https://doi.org/10.2174/1570159x19666210713121217

The three-dimensional structure of an H-superfamily conotoxin reveals a granulin fold arising from a common ICK cysteine framework

Autor: Anastasia Albert, Lars Ellgaard, Mads M. Foged, Terje Vasskog, Samuel D. Robinson, Cecilie L. Søltoft, Raymond S. Norton, Baldomero M. Olivera, Kaare Teilum, Andreas B. Bertelsen, Anthony W. Purcell, Lau Dalby Nielsen, Steen V. Petersen, Helena Safavi-Hemami

Publikováno v: Nielsen, L D, Foged, M M, Albert, A, Bertelsen, A B, Søltoft, C L, Robinson, S D, Petersen, S V, Purcell, A W, Olivera, B M, Norton, R S, Vasskog, T, Safavi-Hemami, H, Teilum, K & Ellgaard, L 2019, ' The three-dimensional structure of an H-superfamily conotoxin reveals a granulin fold arising from a common ICK cysteine framework ', The Journal of Biological Chemistry, vol. 294, no. 22, pp. 8745-8759 . https://doi.org/10.1074/jbc.RA119.007491
Nielsen, L D, Foged, M M, Albert, A, Bertelsen, A B, Søltoft, C L, Robinson, S D, Petersen, S V, Purcell, A W, Olivera, B M, Norton, R S, Vasskog, T, Safavi-Hemami, H, Teilum, K & Ellgaard, L 2019, ' The three-dimensional structure of an H-superfamily conotoxin reveals a granulin fold arising from a common ICK cysteine framework ', The Journal of biological chemistry . https://doi.org/10.1074/jbc.RA119.007491
J Biol Chem
Nielsen, L D, Foged, M M, Albert, A, Bertelsen, A B, Søltoft, C L, Robinson, S D, Petersen, S V, Purcell, A W, Olivera, B M, Norton, R S, Vasskog, T, Safavi-Hemami, H, Teilum, K & Ellgaard, L 2019, ' The three-dimensional structure of an H-superfamily conotoxin reveals a granulin fold arising from a common ICK cysteine framework ', Journal of Biological Chemistry, vol. 294, no. 22, pp. 8745-8759 . https://doi.org/10.1074/jbc.RA119.007491

Venomous marine cone snails produce peptide toxins (conotoxins) that bind ion channels and receptors with high specificity and therefore are important pharmacological tools. Conotoxins contain conserved cysteine residues that form disulfide bonds tha

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6471de4fea35e43d0dc539f45f90b2ee
https://curis.ku.dk/portal/da/publications/the-threedimensional-structure-of-an-hsuperfamily-conotoxin-reveals-a-granulin-fold-arising-from-a-common-ick-cysteine-framework(9a6f9a14-de9a-4f62-adfb-2ff58a676733).html

Mass Spectral Identification of Vc1.1 and Differential Distribution of Conopeptides in the Venom Duct of Conus victoriae. Effect of Post-Translational Modifications and Disulfide Isomerisation on Bioactivity

Autor: Jon-Paul Bingham, H. T. Truong, Paul O'Donnell, Anthony W. Purcell, Bruce G. Livett, John A. Karas, Denis B. Scanlon, A. Townsend, Nicholas A. Williamson

Publikováno v: International Journal of Peptide Research and Therapeutics. 15:195-203

Molluscs of the genus Conus (cone shells) are carnivorous, feeding on marine worms, small fish and other marine molluscs. They capture their prey by injecting venom containing hundreds of neurally active peptide components. These peptides are classed

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2e40b76ccff41b3ac4189230528b1752
https://doi.org/10.1007/s10989-009-9173-4

Hormone-like peptides in the venoms of marine cone snails

Autor: Mark Yandell, Anthony W. Purcell, Anthony T. Papenfuss, Raymond S. Norton, Qing Li, Pradip K. Bandyopadhyay, Samuel D. Robinson, Joanna Gajewiak, Helena Safavi-Hemami

Publikováno v: General and comparative endocrinology. 244

The venoms of cone snails (genus Conus) are remarkably complex, consisting of hundreds of typically short, disulfide-rich peptides termed conotoxins. These peptides have diverse pharmacological targets, with injection of venom eliciting a range of ph

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https://pubmed.ncbi.nlm.nih.gov/26301480

Determining sequences and post-translational modifications of novel conotoxins inConus victoriae using cDNA sequencing and mass spectrometry

Autor: Jonathan V. Sweedler, Ken R. Gayler, Jennifer A. Jakubowski, Bruce G. Livett, Wayne P. Kelley, David A. Keays, Jon-Paul Bingham, David W. Sandall

Publikováno v: Journal of Mass Spectrometry. 39:548-557

A combination of cDNA cloning and detailed mass spectrometric analyses was employed to identify novel conotoxins from Conus victoriae. Eleven conotoxin sequences were determined using molecular methods: one belonging to the A superfamily (Vc1.1), six

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f4d0bc998607ac874fe7c130fefa183
https://doi.org/10.1002/jms.624