Expresión y caracterización biológica de un fragmento de anticuerpo scFv anti-mica candidato para el desarrollo de un biofármaco y su posible aplicación en el tratamiento del cáncer gástrico

Autor: Contreras Reyes, Daniel Alberto

Memoria para optar al título de Químico Farmacéutico
El Cáncer Gástrico es la segunda causa más común de muerte por cáncer en todo el mundo. Las células citolíticas, como las células natural killer (NK) y linfocitos T, desempeñan un

Externí odkaz: http://repositorio.uchile.cl/handle/2250/133998

HDAC5 controls a hypothalamic STAT5b-TH axis, the sympathetic activation of ATP-consuming futile cycles and adult-onset obesity in male mice.

Autor: Contreras RE; Research Unit NeuroBiology of Diabetes, Helmholtz Munich, Neuherberg, Germany; Institute for Diabetes and Obesity, Helmholtz Munich, Neuherberg, Germany; German Center for Diabetes Research (DZD), Neuherberg, Germany; Neurobiology of Diabetes, TUM School of Medicine & Health, Technische Universität München, München, Germany., Gruber T; Institute for Diabetes and Obesity, Helmholtz Munich, Neuherberg, Germany; German Center for Diabetes Research (DZD), Neuherberg, Germany; Van Andel Institute, Grand Rapids, MI, USA., González-García I; Institute for Diabetes and Obesity, Helmholtz Munich, Neuherberg, Germany; German Center for Diabetes Research (DZD), Neuherberg, Germany., Schriever SC; Research Unit NeuroBiology of Diabetes, Helmholtz Munich, Neuherberg, Germany; Institute for Diabetes and Obesity, Helmholtz Munich, Neuherberg, Germany; German Center for Diabetes Research (DZD), Neuherberg, Germany., De Angelis M; Institute for Diabetes and Obesity, Helmholtz Munich, Neuherberg, Germany; German Center for Diabetes Research (DZD), Neuherberg, Germany; Institute of Experimental Genetics, Helmholtz Munich, Neuherberg, Germany., Mallet N; Research Unit NeuroBiology of Diabetes, Helmholtz Munich, Neuherberg, Germany; Institute for Diabetes and Obesity, Helmholtz Munich, Neuherberg, Germany; German Center for Diabetes Research (DZD), Neuherberg, Germany., Bernecker M; Research Unit NeuroBiology of Diabetes, Helmholtz Munich, Neuherberg, Germany; Institute for Diabetes and Obesity, Helmholtz Munich, Neuherberg, Germany; German Center for Diabetes Research (DZD), Neuherberg, Germany; Neurobiology of Diabetes, TUM School of Medicine & Health, Technische Universität München, München, Germany., Legutko B; Institute for Diabetes and Obesity, Helmholtz Munich, Neuherberg, Germany; German Center for Diabetes Research (DZD), Neuherberg, Germany., Kabra D; Research Unit NeuroBiology of Diabetes, Helmholtz Munich, Neuherberg, Germany; Institute for Diabetes and Obesity, Helmholtz Munich, Neuherberg, Germany; German Center for Diabetes Research (DZD), Neuherberg, Germany; Biological Research Pharmacology Department, Sun Pharma Advanced Research Company Ltd., Vadodara, India., Schmidt M; Neurobiology of Stress Resilience, Max Planck Institute of Psychiatry, Munich, Germany., Tschöp MH; Division of Metabolic Diseases, TUM School of Medicine & Health, Technical University of München, Munich, Germany; Helmholtz Center Munich, Neuherberg, Germany., Gutierrez-Aguilar R; División de Investigación, Facultad de Medicina, Universidad Nacional Autónoma de México, Mexico City, Mexico; Laboratorio de Investigación en Enfermedades Metabólicas, Obesidad y Diabetes, Hospital Infantil de México Federico Gomez, Mexico City, Mexico., Mellor J; Department of Biochemistry, University of Oxford, Oxford, UK; Chronos Therapeutics, Oxford, UK., García-Cáceres C; Institute for Diabetes and Obesity, Helmholtz Munich, Neuherberg, Germany; German Center for Diabetes Research (DZD), Neuherberg, Germany; Medical Clinic and Polyclinic IV, Ludwig-Maximilians University of München, Munich, Germany., Pfluger PT; Research Unit NeuroBiology of Diabetes, Helmholtz Munich, Neuherberg, Germany; Institute for Diabetes and Obesity, Helmholtz Munich, Neuherberg, Germany; German Center for Diabetes Research (DZD), Neuherberg, Germany; Neurobiology of Diabetes, TUM School of Medicine & Health, Technische Universität München, München, Germany. Electronic address: paul.pfluger@helmholtz-munich.de.

Publikováno v: Molecular metabolism [Mol Metab] 2024 Sep 19; Vol. 90, pp. 102033. Date of Electronic Publication: 2024 Sep 19.

Research Mapping of Trauma Experiences in Autism Spectrum Disorders: A Bibliometric Analysis.

Autor: Hernández-González O; Faculty of Psychology and Institute of Humanistic Studies Juan Ignacio Molina, Universidad de Talca, Talca 3480094, Chile., Fresno-Rodríguez A; Faculty of Psychology, Universidad de Talca, Talca 3480094, Chile., Spencer-Contreras RE; Faculty of Psychology, Universidad de Talca, Talca 3480094, Chile., Tárraga-Mínguez R; Department of Education, School Management, Faculty of Teacher Training, University of Valencia, 46010 Valencia, Spain., González-Fernández D; Faculty of Health Sciences, Universidad Autónoma de Chile, Santiago 7500912, Chile., Sepúlveda-Opazo F; Faculty of Health Sciences, Universidad de Talca, Talca 3480094, Chile.

Publikováno v: Healthcare (Basel, Switzerland) [Healthcare (Basel)] 2023 Apr 28; Vol. 11 (9). Date of Electronic Publication: 2023 Apr 28.

Obesity-associated hyperleptinemia alters the gliovascular interface of the hypothalamus to promote hypertension.

Autor: Gruber T; Institute for Diabetes and Obesity, Helmholtz Diabetes Center, Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), 85764 Neuherberg, Germany; German Center for Diabetes Research (DZD), 85764 Neuherberg, Germany; Institute for Advanced Studies, Technische Universität, 85748 Garching, Germany., Pan C; Institute for Tissue Engineering and Regenerative Medicine (ITERM), Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), 85764 Neuherberg, Germany; Institute for Stroke and Dementia Research, Klinikum der Universität München, Ludwig Maximilian University of Munich (LMU), 81377 Munich, Germany., Contreras RE; Institute for Diabetes and Obesity, Helmholtz Diabetes Center, Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), 85764 Neuherberg, Germany; German Center for Diabetes Research (DZD), 85764 Neuherberg, Germany; Research Unit Neurobiology of Diabetes, Helmholtz Zentrum München, 85764 Neuherberg, Germany; Neurobiology of Diabetes, TUM School of Medicine, Technical University Munich, 80333 Munich, Germany., Wiedemann T; Institute for Diabetes and Cancer, Helmholtz Diabetes Center, Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), 85764 Neuherberg, Germany., Morgan DA; Department of Neuroscience and Pharmacology, University of Iowa, Iowa City, IA, USA., Skowronski AA; Division of Molecular Genetics, Department of Pediatrics, Vagelos College of Physicians and Surgeons, Naomi Berrie Diabetes Center, Columbia University Irving Medical Center, New York, NY, USA., Lefort S; Institute for Diabetes and Obesity, Helmholtz Diabetes Center, Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), 85764 Neuherberg, Germany; German Center for Diabetes Research (DZD), 85764 Neuherberg, Germany., De Bernardis Murat C; Institute for Diabetes and Obesity, Helmholtz Diabetes Center, Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), 85764 Neuherberg, Germany; German Center for Diabetes Research (DZD), 85764 Neuherberg, Germany., Le Thuc O; Institute for Diabetes and Obesity, Helmholtz Diabetes Center, Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), 85764 Neuherberg, Germany; German Center for Diabetes Research (DZD), 85764 Neuherberg, Germany., Legutko B; Institute for Diabetes and Obesity, Helmholtz Diabetes Center, Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), 85764 Neuherberg, Germany; German Center for Diabetes Research (DZD), 85764 Neuherberg, Germany., Ruiz-Ojeda FJ; German Center for Diabetes Research (DZD), 85764 Neuherberg, Germany; RG Adipocytes & Metabolism, Institute for Diabetes & Obesity, Helmholtz Diabetes Center, Helmholtz Zentrum München, German Research Center for Environmental Health GmbH, 85764 Neuherberg, Germany., Fuente-Fernández M; Physiology Department, School of Medicine, Universidad Autónoma de Madrid, Madrid, Spain., García-Villalón AL; Physiology Department, School of Medicine, Universidad Autónoma de Madrid, Madrid, Spain., González-Hedström D; Physiology Department, School of Medicine, Universidad Autónoma de Madrid, Madrid, Spain., Huber M; Institute for Diabetes and Obesity, Helmholtz Diabetes Center, Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), 85764 Neuherberg, Germany; German Center for Diabetes Research (DZD), 85764 Neuherberg, Germany., Szigeti-Buck K; Program in Integrative Cell Signaling and Neurobiology of Metabolism, Section of Comparative Medicine, Yale University School of Medicine, New Haven, CT, USA., Müller TD; Institute for Diabetes and Obesity, Helmholtz Diabetes Center, Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), 85764 Neuherberg, Germany; German Center for Diabetes Research (DZD), 85764 Neuherberg, Germany; Department of Pharmacology and Experimental Therapy, Institute of Experimental and Clinical Pharmacology and Toxicology, Eberhard Karls University Hospitals and Clinics, Tübingen, Germany., Ussar S; German Center for Diabetes Research (DZD), 85764 Neuherberg, Germany; RG Adipocytes & Metabolism, Institute for Diabetes & Obesity, Helmholtz Diabetes Center, Helmholtz Zentrum München, German Research Center for Environmental Health GmbH, 85764 Neuherberg, Germany; Department of Medicine, Technische Universität, Munich, Germany., Pfluger P; Institute for Diabetes and Obesity, Helmholtz Diabetes Center, Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), 85764 Neuherberg, Germany; German Center for Diabetes Research (DZD), 85764 Neuherberg, Germany; Research Unit Neurobiology of Diabetes, Helmholtz Zentrum München, 85764 Neuherberg, Germany; Neurobiology of Diabetes, TUM School of Medicine, Technical University Munich, 80333 Munich, Germany., Woods SC; Department of Psychiatry and Behavioral Neuroscience, University of Cincinnati, Cincinnati, OH, USA., Ertürk A; Institute for Tissue Engineering and Regenerative Medicine (ITERM), Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), 85764 Neuherberg, Germany; Institute for Stroke and Dementia Research, Klinikum der Universität München, Ludwig Maximilian University of Munich (LMU), 81377 Munich, Germany., LeDuc CA; Division of Molecular Genetics, Department of Pediatrics, Vagelos College of Physicians and Surgeons, Naomi Berrie Diabetes Center, Columbia University Irving Medical Center, New York, NY, USA., Rahmouni K; Department of Neuroscience and Pharmacology, University of Iowa, Iowa City, IA, USA., Granado M; Physiology Department, School of Medicine, Universidad Autónoma de Madrid, Madrid, Spain., Horvath TL; Institute for Advanced Studies, Technische Universität, 85748 Garching, Germany; Program in Integrative Cell Signaling and Neurobiology of Metabolism, Section of Comparative Medicine, Yale University School of Medicine, New Haven, CT, USA., Tschöp MH; Institute for Diabetes and Obesity, Helmholtz Diabetes Center, Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), 85764 Neuherberg, Germany; German Center for Diabetes Research (DZD), 85764 Neuherberg, Germany; Division of Metabolic Diseases, Department of Medicine, Technische Universität, Munich, Germany. Electronic address: matthias.tschoep@helmholtz-muenchen.de., García-Cáceres C; Institute for Diabetes and Obesity, Helmholtz Diabetes Center, Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), 85764 Neuherberg, Germany; German Center for Diabetes Research (DZD), 85764 Neuherberg, Germany; Medizinische Klinik and Poliklinik IV, Klinikum der Universität, Ludwig-Maximilians-Universität München, Munich, Germany. Electronic address: garcia-caceres@helmholtz-muenchen.de.

Publikováno v: Cell metabolism [Cell Metab] 2021 Jun 01; Vol. 33 (6), pp. 1155-1170.e10. Date of Electronic Publication: 2021 May 04.

Erratum. Celastrol-Induced Weight Loss Is Driven by Hypophagia and Independent From UCP1. Diabetes 2018;67:2456-2465.

Autor: Pfuhlmann K, Schriever SC, Baumann P, Kabra DG, Harrison L, Mazibuko-Mbeje SE, Contreras RE, Kyriakou E, Simonds SE, Tiganis T, Cowley MA, Woods SC, Jastroch M, Clemmensen C, De Angelis M, Schramm KW, Sattler M, Messias AC, Tschöp MH, Pfluger PT

Publikováno v: Diabetes [Diabetes] 2019 Mar; Vol. 68 (3), pp. 676. Date of Electronic Publication: 2019 Jan 11.