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Impaired malin expression and interaction with partner proteins in Lafora disease.

Autor: Skurat AV; Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, Indiana, USA; Lafora Epilepsy Cure Initiative, University of Kentucky College of Medicine, Lexington, Kentucky, USA., Segvich DM; Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, Indiana, USA; Lafora Epilepsy Cure Initiative, University of Kentucky College of Medicine, Lexington, Kentucky, USA., Contreras CJ; Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, Indiana, USA; Lafora Epilepsy Cure Initiative, University of Kentucky College of Medicine, Lexington, Kentucky, USA., Hu YC; Division of Developmental Biology, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA., Hurley TD; Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, Indiana, USA; Lafora Epilepsy Cure Initiative, University of Kentucky College of Medicine, Lexington, Kentucky, USA. Electronic address: thurley@iu.edu., DePaoli-Roach AA; Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, Indiana, USA; Lafora Epilepsy Cure Initiative, University of Kentucky College of Medicine, Lexington, Kentucky, USA. Electronic address: adepaoli@iu.edu., Roach PJ; Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, Indiana, USA; Lafora Epilepsy Cure Initiative, University of Kentucky College of Medicine, Lexington, Kentucky, USA.

Publikováno v: The Journal of biological chemistry [J Biol Chem] 2024 May; Vol. 300 (5), pp. 107271. Date of Electronic Publication: 2024 Apr 07.

RIPK3 promotes islet amyloid-induced β-cell loss and glucose intolerance in a humanized mouse model of type 2 diabetes.

Autor: Mukherjee N; Department of Biochemistry & Molecular Biology, Indiana University School of Medicine, Indianapolis, IN, USA., Contreras CJ; Division of Endocrinology, Department of Medicine, Roudebush VA Medical Center and Indiana University School of Medicine, Indianapolis, IN, USA., Lin L; Lilly Diabetes Center of Excellence, Indiana Biosciences Research Institute, Indianapolis, IN, USA., Colglazier KA; Lilly Diabetes Center of Excellence, Indiana Biosciences Research Institute, Indianapolis, IN, USA., Mather EG; Lilly Diabetes Center of Excellence, Indiana Biosciences Research Institute, Indianapolis, IN, USA., Kalwat MA; Lilly Diabetes Center of Excellence, Indiana Biosciences Research Institute, Indianapolis, IN, USA., Esser N; Division of Metabolism, Endocrinology and Nutrition, Department of Medicine, VA Puget Sound Health Care System and the University of Washington, Seattle, WA, USA., Kahn SE; Division of Metabolism, Endocrinology and Nutrition, Department of Medicine, VA Puget Sound Health Care System and the University of Washington, Seattle, WA, USA., Templin AT; Department of Biochemistry & Molecular Biology, Indiana University School of Medicine, Indianapolis, IN, USA; Division of Endocrinology, Department of Medicine, Roudebush VA Medical Center and Indiana University School of Medicine, Indianapolis, IN, USA; Lilly Diabetes Center of Excellence, Indiana Biosciences Research Institute, Indianapolis, IN, USA; Center for Diabetes and Metabolic Diseases, Indiana University School of Medicine, Indianapolis, IN, USA. Electronic address: templin@iu.edu.

Publikováno v: Molecular metabolism [Mol Metab] 2024 Feb; Vol. 80, pp. 101877. Date of Electronic Publication: 2024 Jan 11.

RIPK1 and RIPK3 regulate TNFα-induced β-cell death in concert with caspase activity.

Autor: Contreras CJ; Division of Endocrinology, Department of Medicine, Roudebush VA Medical Center and Indiana University School of Medicine, Indianapolis, IN, USA., Mukherjee N; Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN, USA., Branco RCS; Lilly Diabetes Center of Excellence, Indiana Biosciences Research Institute, Indianapolis, IN, USA., Lin L; Lilly Diabetes Center of Excellence, Indiana Biosciences Research Institute, Indianapolis, IN, USA., Hogan MF; Division of Metabolism, Endocrinology and Nutrition, Department of Medicine, VA Puget Sound Health Care System and University of Washington, Seattle, WA, USA., Cai EP; Lilly Diabetes Center of Excellence, Indiana Biosciences Research Institute, Indianapolis, IN, USA., Oberst AA; Department of Immunology, University of Washington, Seattle, WA, USA., Kahn SE; Division of Metabolism, Endocrinology and Nutrition, Department of Medicine, VA Puget Sound Health Care System and University of Washington, Seattle, WA, USA., Templin AT; Division of Endocrinology, Department of Medicine, Roudebush VA Medical Center and Indiana University School of Medicine, Indianapolis, IN, USA; Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN, USA; Lilly Diabetes Center of Excellence, Indiana Biosciences Research Institute, Indianapolis, IN, USA; Center for Diabetes and Metabolic Diseases, Indiana University School of Medicine, Indianapolis, IN, USA. Electronic address: templin@iu.edu.

Publikováno v: Molecular metabolism [Mol Metab] 2022 Nov; Vol. 65, pp. 101582. Date of Electronic Publication: 2022 Aug 24.

Brain glycogen serves as a critical glucosamine cache required for protein glycosylation.

Autor: Sun RC; Department of Neuroscience, University of Kentucky, Lexington, KY, USA; Markey Cancer Center, University of Kentucky, Lexington, KY, USA. Electronic address: ramon.sun@uky.edu., Young LEA; Department of Molecular and Cellular Biochemistry, University of Kentucky, Lexington, KY, USA; Markey Cancer Center, University of Kentucky, Lexington, KY, USA., Bruntz RC; Department of Molecular and Cellular Biochemistry, University of Kentucky, Lexington, KY, USA., Markussen KH; Department of Molecular and Cellular Biochemistry, University of Kentucky, Lexington, KY, USA., Zhou Z; Department of Molecular and Cellular Biochemistry, University of Kentucky, Lexington, KY, USA., Conroy LR; Department of Neuroscience, University of Kentucky, Lexington, KY, USA; Markey Cancer Center, University of Kentucky, Lexington, KY, USA., Hawkinson TR; Department of Neuroscience, University of Kentucky, Lexington, KY, USA., Clarke HA; Department of Neuroscience, University of Kentucky, Lexington, KY, USA., Stanback AE; Department of Neuroscience, University of Kentucky, Lexington, KY, USA., Macedo JKA; Department of Molecular and Cellular Biochemistry, University of Kentucky, Lexington, KY, USA., Emanuelle S; Department of Molecular and Cellular Biochemistry, University of Kentucky, Lexington, KY, USA., Brewer MK; Department of Molecular and Cellular Biochemistry, University of Kentucky, Lexington, KY, USA; Institute for Research in Biomedicine, Barcelona, Spain., Rondon AL; Department of Molecular and Cellular Biochemistry, University of Kentucky, Lexington, KY, USA., Mestas A; Department of Molecular and Cellular Biochemistry, University of Kentucky, Lexington, KY, USA., Sanders WC; Department of Molecular and Cellular Biochemistry, University of Kentucky, Lexington, KY, USA., Mahalingan KK; Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN, USA., Tang B; Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN, USA., Chikwana VM; Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN, USA., Segvich DM; Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN, USA., Contreras CJ; Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN, USA., Allenger EJ; Department of Physiology, University of Kentucky, Lexington, KY, USA., Brainson CF; Department of Toxicology and Cancer Biology, University of Kentucky, Lexington, KY, USA., Johnson LA; Department of Physiology, University of Kentucky, Lexington, KY, USA., Taylor RE; Department of Chemistry & Biochemistry and the Warren Center for Drug Discovery, University of Notre Dame, Notre Dame, IN, USA., Armstrong DD; Parasail LLC, Boston, MA, USA., Shaffer R; Enable Therapeutics, Boston, MA, USA., Waechter CJ; Department of Molecular and Cellular Biochemistry, University of Kentucky, Lexington, KY, USA., Vander Kooi CW; Department of Molecular and Cellular Biochemistry, University of Kentucky, Lexington, KY, USA; Markey Cancer Center, University of Kentucky, Lexington, KY, USA., DePaoli-Roach AA; Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN, USA., Roach PJ; Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN, USA., Hurley TD; Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN, USA., Drake RR; Cell and Molecular Pharmacology and Experimental Therapeutics, Medical University of South Carolina, Charleston, SC, USA., Gentry MS; Department of Molecular and Cellular Biochemistry, University of Kentucky, Lexington, KY, USA; Markey Cancer Center, University of Kentucky, Lexington, KY, USA. Electronic address: matthew.gentry@uky.edu.

Publikováno v: Cell metabolism [Cell Metab] 2021 Jul 06; Vol. 33 (7), pp. 1404-1417.e9. Date of Electronic Publication: 2021 May 26.