Identification of the intrinsic factors responsible for the increased T-cell mediated anti-tumour responses in Arginase 2 knock-out mice

Autor: Conti, Mark

Cancer is regarded by many as the “disease of the century” and, as such, sparked more and more interest among researchers. Solid evidence indicates that one of the core features of cancer as a whole, is the ability of cancer cells to modify their

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______1400::3db8f10d7d9058cfc78ecfa75bbc12af
https://archive-ouverte.unige.ch/unige:106250

Mitochondrial arginase-2 is a cell‑autonomous regulator of CD8+ T cell function and antitumor efficacy

Autor: Martí I Líndez, Adrià-Arnau, Dunand-Sauthier, Isabelle, Conti, Mark, Gobet, Florian, Núñez, Nicolás, Hannich, J Thomas, Riezman, Howard, Geiger, Roger, Piersigilli, Alessandra, Hahn, Kerstin, Lemeille, Sylvain, Becher, Burkhard, De Smedt, Thibaut, Hugues, Stéphanie, Reith, Walter

As sufficient extracellular arginine is crucial for T cell function, depletion of extracellular arginine by elevated arginase 1 (Arg1) activity has emerged as a hallmark immunosuppressive mechanism. However, the potential cell-autonomous roles of arg

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::07665b609c2f6fadf0149e4496c99737

Mitochondrial arginase-2 is a cell‑autonomous regulator of CD8+ T cell function and antitumor efficacy.

Autor: Martí i Líndez AA; Department of Pathology and Immunology, Faculty of Medicine, University of Geneva, Geneva, Switzerland., Dunand-Sauthier I; Department of Pathology and Immunology, Faculty of Medicine, University of Geneva, Geneva, Switzerland., Conti M; Department of Pathology and Immunology, Faculty of Medicine, University of Geneva, Geneva, Switzerland., Gobet F; Department of Pathology and Immunology, Faculty of Medicine, University of Geneva, Geneva, Switzerland., Núñez N; Institute of Experimental Immunology, University of Zurich, Zurich, Switzerland., Hannich JT; Department of Biochemistry, NCCR Chemical Biology, University of Geneva, Geneva, Switzerland., Riezman H; Department of Biochemistry, NCCR Chemical Biology, University of Geneva, Geneva, Switzerland., Geiger R; Institute for Research in Biomedicine, Università della Svizzera italiana, Bellinzona, Switzerland., Piersigilli A; Histology Core Facility, School of Life Sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland.; Institute of Animal Pathology, Vetsuisse Faculty, University of Bern, Bern, Switzerland., Hahn K; Institute of Animal Pathology, Vetsuisse Faculty, University of Bern, Bern, Switzerland., Lemeille S; Department of Pathology and Immunology, Faculty of Medicine, University of Geneva, Geneva, Switzerland., Becher B; Institute of Experimental Immunology, University of Zurich, Zurich, Switzerland., De Smedt T; Department of Pathology and Immunology, Faculty of Medicine, University of Geneva, Geneva, Switzerland., Hugues S; Department of Pathology and Immunology, Faculty of Medicine, University of Geneva, Geneva, Switzerland., Reith W; Department of Pathology and Immunology, Faculty of Medicine, University of Geneva, Geneva, Switzerland.

Publikováno v: JCI insight [JCI Insight] 2019 Nov 21; Vol. 4 (24). Date of Electronic Publication: 2019 Nov 21.