Homologation of mexiletine alkyl chain and stereoselective blockade of skeletal muscle sodium channels

Autor: De Luca A, Conte Camerino D, Carlo Franchini, Sabata Pierno, Tortorella, Fulvio Loiodice, Andrea Duranti, Giovanni Lentini

Publikováno v: European Journal of Medicinal Chemistry. 35:147-156

The optical isomers (-)-(S)- and (+)-(R)-3-(2,6-dimethylphenoxy)-2-methyl-1-propanamine (Me2), homologues of the antiarrhythmic and antimyotonic drug mexiletine (Mex), were synthesized and assayed as new potential antimyotonic agents. As observed wit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fca43eb42d0a5e8cc8d9811f3b571f58
https://doi.org/10.1016/s0223-5234(00)00115-x

The MDS mission on ISS: Muscle atrophy signaling pathways in mice after 92 days in space

Autor: Betto, R, Sandona', Dorianna, Danieli, Daniela, Musaro’, A, Mele, A, Digennaro, C, CONTE CAMERINO, D, Blottner, D, Ohira, Y, Schiaffino, Stefano

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______3657::3ffdfcc28ec9910c3cacd2ef733aac65
http://hdl.handle.net/11577/2419329

Short-, medium- and long-term effects on skeletal muscles in pre-flight tests of MDS mission

Autor: Franzoso, S., Sandona', Dorianna, Betto, R., Germinario, Elena, Danieli, Daniela, Dobrowolny, G., Musarò, A., Pierno, S., Camerino, G. M., Desaphy, J. F., Conte Camerino, D., S. Schiaffino S.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______3657::5c0d6b5232a346ff9541f24bf546c6f8
http://hdl.handle.net/11577/2372774

Molecular switch for CLC-K Cl- channel block/activation: optimal pharmacophoric requirements towards high affinity ligands

Autor: Liantonio A, Picollo A, Carbonara G, Fracchiolla G, Tortorella P, Loiodice F, Laghezza A, Babini E, Zifarelli G, Pusch M, Conte Camerino D.

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America 105 (2008): 1369–1373.
info:cnr-pdr/source/autori:Liantonio A, Picollo A, Carbonara G, Fracchiolla G, Tortorella P, Loiodice F, Laghezza A, Babini E, Zifarelli G, Pusch M, Conte Camerino D./titolo:Molecular switch for CLC-K Cl-channel block%2Factivation: optimal pharmacophoric requirements towards high affinity ligands./doi:/rivista:Proceedings of the National Academy of Sciences of the United States of America/anno:2008/pagina_da:1369/pagina_a:1373/intervallo_pagine:1369–1373/volume:105

ClC-Ka and ClC-Kb Cl(-) channels are pivotal for renal salt reabsorption and water balance. There is growing interest in identifying ligands that allow pharmacological interventions aimed to modulate their activity. Starting from available ligands, w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=cnr_________::7a85c92d4db7d139106377b085d9a797
http://www.cnr.it/prodotto/i/9674

Investigations of pharmacological properties of the renal ClC-K1 chloride channel co-expressed with barttin by the use of 2-(p-chlorophenoxy)propionic acid derivatives and other structurally unrelated chloride channels blockers

Autor: Liantonio A., Pusch M., Picollo A., Guida P., De Luca A., Pierno S., Fracchiolla G., Loiodice F., Tortorella P., Conte Camerino D.

Publikováno v: Journal of the American Society of Nephrology 15 (2004): 13–20.
info:cnr-pdr/source/autori:Liantonio A., Pusch M., Picollo A., Guida P., De Luca A., Pierno S., Fracchiolla G., Loiodice F., Tortorella P., Conte Camerino D./titolo:Investigations of pharmacological properties of the renal ClC-K1 chloride channel co-expressed with barttin by the use of 2-(p-chlorophenoxy)propionic acid derivatives and other structurally unrelated chloride channels blockers./doi:/rivista:Journal of the American Society of Nephrology/anno:2004/pagina_da:13/pagina_a:20/intervallo_pagine:13–20/volume:15

CLC-K chloride channels are expressed in the kidney, where they play a pivotal role in the mechanisms of urine concentration and Na(+) reabsorption. The identification of barttin as an essential beta-subunit of CLC-K channels allowed performance of a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=cnr_________::e57ad07755ba3be9816cfd19cae6e3d9
https://publications.cnr.it/doc/9240