Solidagenone acts on promastigotes of L. amazonensis by inducing apoptosis-like processes on intracellular amastigotes by IL-12p70/ROS/NO pathway activation.

Autor: Bortoleti BTDS; Biosciences and Biotechnology Postgraduate Program, Carlos Chagas Institute (ICC/Fiocruz-PR), Curitiba, Paraná, Brazil; State University of Londrina (UEL/PR), Laboratory of Immunoparasitology, Londrina, Paraná, Brazil., Gonçalves MD; State University of Londrina (UEL/PR), Laboratory of Biotransformation and Phytochemistry, Londrina, Paraná, Brazil., Tomiotto-Pellissier F; Biosciences and Biotechnology Postgraduate Program, Carlos Chagas Institute (ICC/Fiocruz-PR), Curitiba, Paraná, Brazil; State University of Londrina (UEL/PR), Laboratory of Immunoparasitology, Londrina, Paraná, Brazil., Contato VM; State University of Londrina (UEL/PR), Laboratory of Immunoparasitology, Londrina, Paraná, Brazil., Silva TF; State University of Londrina (UEL/PR), Laboratory of Immunoparasitology, Londrina, Paraná, Brazil., de Matos RLN; State University of Londrina (UEL/PR), Laboratory of Biotransformation and Phytochemistry, Londrina, Paraná, Brazil., Detoni MB; State University of Londrina (UEL/PR), Laboratory of Immunoparasitology, Londrina, Paraná, Brazil., Rodrigues ACJ; State University of Londrina (UEL/PR), Laboratory of Immunoparasitology, Londrina, Paraná, Brazil., Carloto AC; State University of Londrina (UEL/PR), Laboratory of Immunoparasitology, Londrina, Paraná, Brazil., Lazarin DB; State University of Londrina (UEL/PR), Laboratory of Immunoparasitology, Londrina, Paraná, Brazil., Arakawa NS; State University of Londrina (UEL/PR), Laboratory of Biotransformation and Phytochemistry, Londrina, Paraná, Brazil., Costa IN; State University of Londrina (UEL/PR), Laboratory of Immunoparasitology, Londrina, Paraná, Brazil., Conchon-Costa I; State University of Londrina (UEL/PR), Laboratory of Immunoparasitology, Londrina, Paraná, Brazil., Miranda-Sapla MM; State University of Londrina (UEL/PR), Laboratory of Immunoparasitology, Londrina, Paraná, Brazil., Wowk PF; Carlos Chagas Institute (ICC/Fiocruz-PR), Laboratory of Molecular Virology, Curitiba, Paraná, Brazil. Electronic address: pryscilla.wowk@fiocruz.br., Pavanelli WR; State University of Londrina (UEL/PR), Laboratory of Immunoparasitology, Londrina, Paraná, Brazil. Electronic address: wanderpavanelli@yahoo.com.br.

Publikováno v: Phytomedicine : international journal of phytotherapy and phytopharmacology [Phytomedicine] 2021 May; Vol. 85, pp. 153536. Date of Electronic Publication: 2021 Mar 03.