Fetal Central Nervous System Derived Extracellular Vesicles: Potential for Non-invasive Tracking of Viral Mediated Fetal Brain Injury

Autor: Laura Goetzl, Angela J. Stephens, Yechiel Schlesinger, Nune Darbinian, Nana Merabova, Miriam Hillel, Alec J. Hirsch, Daniel N. Streblow, Antonio E. Frias, Victoria H. J. Roberts, Nicole N. Haese, Arunmani Mani, Yifat Eldar-Yedidia

Publikováno v: Frontiers in Virology, Vol 1 (2021)

Introduction: Extracellular vesicles derived from the fetal central nervous system (FCNSEs) can be purified from maternal serum or plasma using the protein Contactin-2/TAG1that is expressed almost exclusively by developing neurons in the hippocampus,

Externí odkaz: https://doaj.org/article/311dd73ce289441aa9742497f6f4b333

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Contactin-2, a synaptic and axonal protein, is reduced in cerebrospinal fluid and brain tissue in Alzheimer’s disease

Autor: Jeroen J.M. Hoozemans, Marta Del Campo, Wiesje M. van der Flier, Matthijs de Waal, Madhurima Chatterjee, Charlotte E. Teunissen, Tjado H. J. Morrema

Publikováno v: Alzheimer’s Research & Therapy, Vol 10, Iss 1, Pp 1-11 (2018)
Alzheimer's Research & Therapy, 10(1). BioMed Central
Chatterjee, M, Del Campo, M, Morrema, T H J, de Waal, M, van der Flier, W M, Hoozemans, J J M & Teunissen, C E 2018, ' Contactin-2, a synaptic and axonal protein, is reduced in cerebrospinal fluid and brain tissue in Alzheimer's disease ', Alzheimer's Research & Therapy, vol. 10, no. 1, pp. 52 . https://doi.org/10.1186/s13195-018-0383-x
Alzheimer's Research & Therapy

Background Synaptic and axonal loss are two major mechanisms underlying Alzheimer’s disease (AD) pathogenesis, and biomarkers reflecting changes in these cellular processes are needed for early diagnosis and monitoring the progression of AD. Contac

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e734f2098f25ae11f98b61326b6c4788
http://link.springer.com/article/10.1186/s13195-018-0383-x

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