Výsledky vyhledávání - "Consuelo L. McCash"

In Utero Exposure of Female CD-1 Mice to AZT and/or 3TC: I. Persistence of Microscopic Lesions in Cardiac Tissue

Autor: Thomas H. March, Vernon E. Walker, Miriam C. Poirier, Consuelo L. McCash, Meghan M. Carter, Steven K. Seilkop, Salina M. Torres, Dale M. Walker

Publikováno v: Cardiovascular Toxicology. 10:37-50

The current study was designed to delineate temporal changes in cardiomyocytes and mitochondria at the light and electron microscopic levels in hearts of mice exposed transplacentally to commonly used nucleoside analogs (NRTIs). Pregnant CD-1 mice we

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c849f7daa53f6b10a32d181a5a01c5a
https://doi.org/10.1007/s12012-010-9061-3

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WR1065 mitigates AZT-ddI-induced mutagenesis and inhibits viral replication

Autor: Ofelia A. Olivero, Andrew W. Hardy, Miriam C. Poirier, Adriana E. Kajon, Dale M. Walker, Salina M. Torres, Vernon E. Walker, Consuelo L. McCash, Patricia B. Upton, Meghan M. Carter, James A. Swenberg, Gene M. Shearer

Publikováno v: Environmental and Molecular Mutagenesis. 50:460-472

The success of nucleoside reverse transcriptase inhibitors (NRTIs) in treating HIV-1 infection and reducing mother-to-child transmission of the virus during pregnancy is accompanied by evidence that NRTIs cause long-term health risks for cancer and m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b2e18760cdefb65d926478f617d9cbf
https://doi.org/10.1002/em.20482

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Mutagenicity of zidovudine, lamivudine, and abacavir following in vitro exposure of human lymphoblastoid cells or in utero exposure of CD-1 mice to single agents or drug combinations

Autor: Consuelo L. McCash, Dennis L. Cook, Ofelia A. Olivero, Meghan M. Carter, Vernon E. Walker, Salina M. Torres, Miriam C. Poirier, Dale M. Walker, Edmund M. Cordova

Publikováno v: Environmental and Molecular Mutagenesis. 48:224-238

Experiments were performed to investigate the impact of zidovudine (AZT), lamivudine (3TC), and abacavir (ABC) on cell survival and mutagenicity in two reporter genes, hypoxanthine-guanine phosphoribosyltransferase (HPRT) and thymidine kinase (TK), u

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::590bf6bd595b2c57799b8423f54dbe10
https://doi.org/10.1002/em.20264

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In utero exposure of female CD-1 mice to AZT and/or 3TC: II. Persistence of functional alterations in cardiac tissue

Autor: Miriam C. Poirier, Matthew J. Campen, Yvonne Chu, Huining Kang, Salina M. Torres, Steven K. Seilkop, Dale M. Walker, Meghan M. Carter, Vernon E. Walker, Rao L. Divi, Tracey L. Einem, Consuelo L. McCash

Publikováno v: Cardiovascular toxicology. 10(2)

To delineate temporal changes in the integrity and function of mitochondria/cardiomyocytes in hearts from mice exposed in utero to commonly used nucleoside analogs (NRTIs), CD-1 mice were exposed in utero to 80 mg AZT/kg, 40 mg 3TC/kg, 80 mg AZT/kg p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28177fed27d43a35bb94f3a14d669f7e
https://pubmed.ncbi.nlm.nih.gov/20155331

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Mutational analysis of the mitochondrial tRNA genes and flanking regions in umbilical cord tissue from uninfected infants receiving AZT-based therapies for prophylaxis of HIV-1

Autor: Edmund M. Cordova, Rachel M. Pons, Salina M. Torres, Consuelo L. McCash, Steven K. Seilkop, Vernon E. Walker, Jessica Ming, Dale M. Walker, William C. Copeland, Dennis L. Cook, Meghan M. Carter

Publikováno v: Environmental and molecular mutagenesis. 50(1)

A sensitive vertical denaturing gradient gel electrophoresis (DGGE) method, using 13 unipolar psoralen-clamped PCR primer pairs, was developed for detecting sequence variants in the 22 tRNA genes and flanking regions (together spanning approximately

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17e47caf78c894fe0a5138b127452fb8
https://pubmed.ncbi.nlm.nih.gov/19031409

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Relative mutagenic potencies of several nucleoside analogs, alone or in drug pairs, at the HPRT and TK loci of human TK6 lymphoblastoid cells

Autor: Vernon E. Walker, Mia Yu, Consuelo L. McCash, Dennis L. Cook, Salina M. Torres, Dale M. Walker, Meghan M. Carter

Publikováno v: Environmental and molecular mutagenesis. 48(3-4)

Experiments were performed to investigate the impact of didanosine (ddI), lamivudine (3TC), and stavudine (d4T) on cell survival and mutagenicity in two reporter genes, hypoxanthine-guanine phosphoribosyltransferase (HPRT) and thymidine kinase (TK),

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81a3d2976c3c0be0b87336fa6c1467e9
https://pubmed.ncbi.nlm.nih.gov/17358029

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Mitochondrial toxicity in hearts of CD-1 mice following perinatal exposure to AZT, 3TC, or AZT/3TC in combination

Autor: Sherine S.L. Chan, Janine H. Santos, Grace E. Kissling, Abraham Nyska, Kristine L. Witt, William C. Copeland, Julie F. Foley, Bhaskar S. Mandavilli, Bennett Van Houten, Joel N. Meyer, Vernon E. Walker, Consuelo L. McCash, Jack B. Bishop, Dennis L. Cook

Publikováno v: Environmental and molecular mutagenesis. 48(3-4)

Antiretroviral therapies based on nucleoside reverse transcriptase inhibitors (NRTIs), like zidovudine (3′-azido-3′-deoxythymidine; AZT) and lamivudine ((-)2′,3′-dideoxy-3′-thiacytidine; 3TC), markedly reduce mother-to-child transmission of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::673da1028a9d1e3b8ee7ec0375a41821
https://pubmed.ncbi.nlm.nih.gov/16395692

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Age-, gender-, and species-dependent mutagenicity in T cells of mice and rats exposed by inhalation to 1,3-butadiene

Autor: Quanxin Meng, Dale M. Walker, Jake D. McDonald, Rogene F. Henderson, Meghan M. Carter, Dennis L. Cook, null Jr., Consuelo L. McCash, Salina M. Torres, Michael J. Bauer, Steven K. Seilkop, Patricia B. Upton, Nadia I. Georgieva, Gunnar Boysen, James A. Swenberg, Vernon E. Walker

Publikováno v: Chemico-biological interactions. 166(1-3)

Experiments were performed: (i) to investigate potential age- and gender-dependent differences in mutagenic responses in T cells following exposures of B6C3F1 mice and F344 rats by inhalation for 2 weeks to 0 or 1250 ppm butadiene (BD), and (ii) to d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f96bb9b3bbb738bc0ce451d7c473af21
https://pubmed.ncbi.nlm.nih.gov/16945358

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