Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Consuelo Garcia-Rodriguez"'
Autor:
Yongfeng Fan, Jianlong Lou, Christina C. Tam, Weihua Wen, Fraser Conrad, Priscila Leal da Silva Alves, Luisa W. Cheng, Consuelo Garcia-Rodriguez, Shauna Farr-Jones, James D. Marks
Publikováno v:
Toxins, Vol 15, Iss 5, p 316 (2023)
Equine-derived antitoxin (BAT®) is the only treatment for botulism from botulinum neurotoxin serotype G (BoNT/G). BAT® is a foreign protein with potentially severe adverse effects and is not renewable. To develop a safe, more potent, and renewable
Externí odkaz:
https://doaj.org/article/276c0b76216c46e0a1b5bb0297a8d1eb
Autor:
Consuelo Garcia-Rodriguez, Shude Yan, Isin N. Geren, Kristeene A. Knopp, Jianbo Dong, Zhengda Sun, Jianlong Lou, Fraser Conrad, Wei-Hua Wen, Shauna Farr-Jones, Theresa J. Smith, Jennifer L. Brown, Janet C. Skerry, Leonard A. Smith, James D. Marks
Publikováno v:
Toxins, Vol 13, Iss 9, p 641 (2021)
Human botulism can be caused by botulinum neurotoxin (BoNT) serotypes A to G. Here, we present an antibody-based antitoxin composed of four human monoclonal antibodies (mAbs) against BoNT/C, BoNT/D, and their mosaic toxins. This work built on our suc
Externí odkaz:
https://doaj.org/article/a25047536f784a189fd6ca0fc69595fc
Autor:
Yongfeng Fan, Jianbo Dong, Jianlong Lou, Weihua Wen, Fraser Conrad, Isin N. Geren, Consuelo Garcia-Rodriguez, Theresa J. Smith, Leonard A. Smith, Mengfei Ho, Melissa Pires-Alves, Brenda A. Wilson, James D. Marks
Publikováno v:
Toxins, Vol 7, Iss 9, Pp 3405-3423 (2015)
Existing antibodies (Abs) used to treat botulism cannot enter the cytosol of neurons and bind to botulinum neurotoxin (BoNT) at its site of action, and thus cannot reverse paralysis. However, Abs targeting the proteolytic domain of the toxin could in
Externí odkaz:
https://doaj.org/article/6b1b373bea8b45a2adb6651086bec8a0
Autor:
Yongfeng Fan, Consuelo Garcia-Rodriguez, Jianlong Lou, Weihua Wen, Fraser Conrad, Wenwu Zhai, Theresa J Smith, Leonard A Smith, James D Marks
Publikováno v:
PLoS ONE, Vol 12, Iss 3, p e0174187 (2017)
Human botulism is primarily caused by botulinum neurotoxin (BoNT) serotypes A, B and E, with around 1% caused by serotype F (BoNT/F). BoNT/F comprises at least seven different subtypes with the amino acid sequence difference between subtypes as high
Externí odkaz:
https://doaj.org/article/6184a309773e437897fdc911de7196ba
Autor:
Consuelo Garcia-Rodriguez, Ali Razai, Isin N. Geren, Jianlong Lou, Fraser Conrad, Wei-Hua Wen, Shauna Farr-Jones, Theresa J. Smith, Jennifer L. Brown, Janet C. Skerry, Leonard A. Smith, James D. Marks
Publikováno v:
Toxins, Vol 10, Iss 3, p 105 (2018)
Human botulism is most commonly caused by botulinum neurotoxin (BoNT) serotypes A, B, and E. For this work, we sought to develop a human monoclonal antibody (mAb)-based antitoxin capable of binding and neutralizing multiple subtypes of BoNT/E. Librar
Externí odkaz:
https://doaj.org/article/49f299afeb6e4e768559329a7626fa78
Autor:
Jianlong Lou, Weihua Wen, Fraser Conrad, Qi Meng, Jianbo Dong, Zhengda Sun, Consuelo Garcia-Rodriguez, Shauna Farr-Jones, Luisa W. Cheng, Thomas D. Henderson, Jennifer L. Brown, Theresa J. Smith, Leonard A. Smith, Anthony Cormier, James D. Marks
Publikováno v:
Toxins, Vol 10, Iss 2, p 84 (2018)
The standard of treatment for botulism, equine antitoxin, is a foreign protein with associated safety issues and a short serum half-life which excludes its use as a prophylactic antitoxin and makes it a less-than-optimal therapeutic. Due to these lim
Externí odkaz:
https://doaj.org/article/bda61dc1667e434a82809f2a43e8daa6
Autor:
Suzanne R Kalb, Consuelo Garcia-Rodriguez, Jianlong Lou, Jakub Baudys, Theresa J Smith, James D Marks, Leonard A Smith, James L Pirkle, John R Barr
Publikováno v:
PLoS ONE, Vol 5, Iss 8, p e12237 (2010)
Botulinum neurotoxins (BoNTs) are extremely potent toxins that are capable of causing respiratory failure leading to long-term intensive care or death. The best treatment for botulism includes serotype-specific antitoxins, which are most effective wh
Externí odkaz:
https://doaj.org/article/9caf32e0dd4847e3b0283cc991a9e87a
Autor:
Suzanne R Kalb, Jianlong Lou, Consuelo Garcia-Rodriguez, Isin N Geren, Theresa J Smith, Hercules Moura, James D Marks, Leonard A Smith, James L Pirkle, John R Barr
Publikováno v:
PLoS ONE, Vol 4, Iss 4, p e5355 (2009)
Botulinum neurotoxins (BoNTs) are extremely potent toxins that are capable of causing death or respiratory failure leading to long-term intensive care. Treatment includes serotype-specific antitoxins, which must be administered early in the course of
Externí odkaz:
https://doaj.org/article/d9de18d06e124a92a755cd820f3789e2
Autor:
James D. Marks, Consuelo Garcia-Rodriguez, Ronald R. Cobb, Khanh Pham, Fraser Conrad, Carl N Kraus, Angie Kimbler, Kathryn Riling, David Wong, Doris M Snow, Milan T. Tomic, Zachary Martinez, Yero Espinoza
Publikováno v:
Antimicrobial Agents and Chemotherapy
Antimicrobial agents and chemotherapy, vol 63, iss 12
Antimicrobial agents and chemotherapy, vol 63, iss 12
Botulism is caused by botulinum neurotoxin (BoNT), the most poisonous substance known. BoNTs are also classified as tier 1 biothreat agents due to their high potency and lethality. The existence of seven BoNT serotypes (A to G), which differ by 35% t
Autor:
Janet C Skerry, James D. Marks, Isin N. Geren, Leonard A. Smith, Weihua Wen, Jianlong Lou, Ali Razai, Shauna Farr-Jones, Jennifer L Brown, Consuelo Garcia-Rodriguez, Theresa J. Smith, Fraser Conrad
Publikováno v:
Toxins, vol 10, iss 3
Toxins, Vol 10, Iss 3, p 105 (2018)
Toxins; Volume 10; Issue 3; Pages: 105
Toxins
Toxins, Vol 10, Iss 3, p 105 (2018)
Toxins; Volume 10; Issue 3; Pages: 105
Toxins
Human botulism is most commonly caused by botulinum neurotoxin (BoNT) serotypes A, B, and E. For this work, we sought to develop a human monoclonal antibody (mAb)-based antitoxin capable of binding and neutralizing multiple subtypes of BoNT/E. Librar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc476a871850a703503a00e8592da7e3
https://escholarship.org/uc/item/7p61r8w4
https://escholarship.org/uc/item/7p61r8w4