A Cell-Based Platform for the Investigation of Immunoproteasome Subunit β5i Expression and Biology of β5i-Containing Proteasomes

Autor: Alexander Burov, Sergei Funikov, Elmira Vagapova, Alexandra Dalina, Alexander Rezvykh, Elena Shyrokova, Timofey Lebedev, Ekaterina Grigorieva, Vladimir Popenko, Olga Leonova, Daria Spasskaya, Pavel Spirin, Vladimir Prassolov, Vadim Karpov, Alexey Morozov

Publikováno v: Cells, Vol 10, Iss 11, p 3049 (2021)

The degradation of most intracellular proteins is a dynamic and tightly regulated process performed by proteasomes. To date, different forms of proteasomes have been identified. Currently the role of non-constitutive proteasomes (immunoproteasomes (i

Externí odkaz: https://doaj.org/article/19082ea56f0d4d82a9b1d7c06365760f

A Cell-Based Platform for the Investigation of Immunoproteasome Subunit β5i Expression and Biology of β5i-Containing Proteasomes

Autor: Elena Shyrokova, Sergei Funikov, Alexander Burov, Alexander P. Rezvykh, Pavel Spirin, Vadim L. Karpov, Elmira Vagapova, Vladimir S. Prassolov, T D Lebedev, Ekaterina Grigorieva, Vladimir I. Popenko, Alexandra A. Dalina, O. G. Leonova, A. V. Morozov, Daria S. Spasskaya

Publikováno v: Cells
Cells, Vol 10, Iss 3049, p 3049 (2021)
Volume 10
Issue 11

The degradation of most intracellular proteins is a dynamic and tightly regulated process performed by proteasomes. To date, different forms of proteasomes have been identified. Currently the role of non-constitutive proteasomes (immunoproteasomes (i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bbb883d572f56ff4104fb8aa07496ad4
https://pubmed.ncbi.nlm.nih.gov/34831272

Tetradehydrohalicyclamine B, a new proteasome inhibitor from the marine sponge Acanthostrongylophora ingens

Autor: El-Desoky, Ahmed H., Nehira, Tatsuo, Angkouw, Esther D., Mangindaan, Remy E.P., de Voogd, Nicole J., Hikaru, Kato, Ahmed H. , El-Desoky, Yuya, Takeishi, Tesuo, Nehira, Esther D. , Angkouw, Remy E.P. , Mangindaan, Nicole J. , de Voogd, Sachiko, Tsukamoto

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 29:8-10

A new halicyclamine derivative, tetradehydrohalicyclamine B (1), was isolated from the marine sponge Acanthostrongylophora ingens, along with halicyclamine B (2) as proteasome inhibitors. Compound 1 is the second example found to have a pyridinium ri

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31e9a35a0d0604c9d44849a3a3407736
https://doi.org/10.1016/j.bmcl.2018.11.028

Proteasomes and Several Aspects of Their Heterogeneity Relevant to Cancer

Autor: Vadim L. Karpov, A. V. Morozov

Publikováno v: Frontiers in Oncology, Vol 9 (2019)
Frontiers in Oncology

The life of every organism is dependent on the fine-tuned mechanisms of protein synthesis and breakdown. The degradation of most intracellular proteins is performed by the ubiquitin proteasome system (UPS). Proteasomes are central elements of the UPS

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b27c81625c6a3e5f6d6b1b2721e156e
https://www.frontiersin.org/article/10.3389/fonc.2019.00761/full

Structure-based design of human immuno- and constitutive proteasomes inhibitors

Autor: Nicolas Richy, Michèle Reboud-Ravaux, Naëla Janmamode, Joëlle Vidal, Xavier Maréchal, Daad Sarraf, Emilie Genin, Rémy Le Guével

Publikováno v: European Journal of Medicinal Chemistry
European Journal of Medicinal Chemistry, Elsevier, 2018, 145, pp.570-587. ⟨10.1016/j.ejmech.2018.01.013⟩
European Journal of Medicinal Chemistry, 2018, 145, pp.570-587. ⟨10.1016/j.ejmech.2018.01.013⟩

International audience; Starting from the X-ray structure of our previous tripeptidic linear mimics of TMC-95A in complex with yeast 20S proteasome, we introduced new structural features to induce a differential inhibition between human constitutive

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb14a3808b0075f834d5dec020e04418
https://hal-univ-rennes1.archives-ouvertes.fr/hal-01713510/document