Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Constanze Knebel"'
Autor:
Constanze Knebel, Roderich D. Süssmuth, Helen S. Hammer, Albert Braeuning, Philip Marx-Stoelting
Publikováno v:
Cells, Vol 11, Iss 20, p 3293 (2022)
Triazole fungicides such as propiconazole (Pi) or tebuconazole (Te) show hepatotoxicity in vivo, e.g., hypertrophy and vacuolization of liver cells following interaction with nuclear receptors such as PXR (pregnane-X-receptor) and CAR (constitutive a
Externí odkaz:
https://doaj.org/article/d949b29fe11a42e0ba78bcdc32af96ef
Publikováno v:
Cells, Vol 9, Iss 5, p 1192 (2020)
Azole fungicides, especially triazole compounds, are widely used in agriculture and as pharmaceuticals. For a considerable number of agricultural azole fungicides, the liver has been identified as the main target organ of toxicity. A number of previo
Externí odkaz:
https://doaj.org/article/5487efc0d6bd4d35834c990fb04bd0f8
Autor:
Constanze Knebel, Philip Marx-Stoelting, Albert Braeuning, Alfonso Lampen, Roderich D. Süssmuth, Thorsten Buhrke
Publikováno v:
Archives of Toxicology. 93:1311-1322
Triazoles are commonly used fungicides which show liver toxicity in rodent studies. While hepatocellular hypertrophy is the most prominent finding, some triazoles have also been reported to cause hepatocellular steatosis. The aim of our study was to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0efd8145d51a1e2c75e057c16718ef19
https://doi.org/10.1007/s00204-019-02445-2
https://doi.org/10.1007/s00204-019-02445-2
Autor:
Constanze Knebel, T. Heise, Philip Marx-Stoelting, Albert Braeuning, Ulrich M. Zanger, Alfonso Lampen
Publikováno v:
Food and Chemical Toxicology. 123:481-491
Tebuconazole, a member of the triazole group of fungicides, exerts hepatotoxicity in rodent studies. Knowledge on the molecular mechanisms underlying tebuconazole toxicity is limited. Previous studies suggest that activation of xenobiotic-sensing nuc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69dc39495c68edb4430b278cd7fef422
https://doi.org/10.1016/j.fct.2018.11.039
https://doi.org/10.1016/j.fct.2018.11.039
Autor:
Jess Baker, Jane Kohlhoff, Se-Inyenede Onobrakpor, Sue Woolfenden, Rebecca Smith, Constanze Knebel, Valsamma Eapen
BACKGROUND Web-based developmental surveillance programs may be an innovative solution to improving the early detection of childhood developmental difficulties, especially within disadvantaged populations. OBJECTIVE This review aimed to identify the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::829060aaac59188f2680717c34ae081b
https://doi.org/10.2196/preprints.16085
https://doi.org/10.2196/preprints.16085
Autor:
T. Heise, Constanze Knebel, Philip Marx-Stoelting, Stephan Albaum, Thomas Noll, Pablo Steinberg, F. Schmidt, Almut Mentz, Hanna Bednarz, Jörn Kalinowski, Bettina Seeger, Karsten Niehaus
Consumers are constantly exposed to chemical mixtures such as multiple residues of different pesticides via the diet. This raises questions concerning potential combination effects, especially because these substances are tested for regulatory purpos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63eb6a8f631897339df9b98885f71bc3
https://doi.org/10.1007/s00204-019-02502-w
https://doi.org/10.1007/s00204-019-02502-w
Publikováno v:
Cells
Cells, Vol 9, Iss 1192, p 1192 (2020)
Cells, Vol 9, Iss 1192, p 1192 (2020)
Azole fungicides, especially triazole compounds, are widely used in agriculture and as pharmaceuticals. For a considerable number of agricultural azole fungicides, the liver has been identified as the main target organ of toxicity. A number of previo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3346576d2821f0d67a6a19565a2951a
https://doi.org/10.3390/cells9051192
https://doi.org/10.3390/cells9051192
Autor:
Se-Inyenede Onobrakpor, Jane Kohlhoff, Constanze Knebel, J. R. Baker, Valsamma Eapen, Susan Woolfenden, Rebecca Smith
Publikováno v:
JMIR mHealth and uHealth, Vol 8, Iss 4, p e16085 (2020)
JMIR mHealth and uHealth
JMIR mHealth and uHealth
Background Web-based developmental surveillance programs may be an innovative solution to improving the early detection of childhood developmental difficulties, especially within disadvantaged populations. Objective This review aimed to identify the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0c1d6b76f85ec48895c38fb302f52a0
https://doi.org/10.2196/16085
https://doi.org/10.2196/16085
Autor:
Alfonso Lampen, Roderich D. Süssmuth, T. Heise, Albert Braeuning, Constanze Knebel, Helen Hammer, Stefanie Hessel-Pras, Ivano Eberini, Juliane Kebben, Philip Marx-Stoelting, Luca Palazzolo
Publikováno v:
Archives of toxicology. 92(12)
Consumers are exposed to pesticide residues and other food contaminants via the diet. Both can exert adverse effects on different target organs via the activation of nuclear receptor pathways. Hepatotoxic effects of the widely used triazole fungicide
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b807343bdec7d1a1075d7d6e70cada40
https://pubmed.ncbi.nlm.nih.gov/30293151
https://pubmed.ncbi.nlm.nih.gov/30293151
Autor:
Jannika Neeb, Alfonso Lampen, Constanze Knebel, Roderich D. Süssmuth, Philip Marx-Stoelting, Petr Pavek, Elisabeth Zahn, Gerhard Püschel, Albert Braeuning, Ondej Holas, F. Schmidt, Ulrich M. Zanger, Alejandro Carazo
Publikováno v:
Toxicological sciences : an official journal of the Society of Toxicology. 163(1)
Analyzing mixture toxicity requires an in-depth understanding of the mechanisms of action of its individual components. Substances with the same target organ, same toxic effect and same mode of action (MoA) are believed to cause additive effects, whe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::671e8a06c13fe1a269db54bab3afc214
https://pubmed.ncbi.nlm.nih.gov/29420809
https://pubmed.ncbi.nlm.nih.gov/29420809