Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Constanze Breitinger"'
Autor:
Emanuel Maethner, Maria-Paz Garcia-Cuellar, Constanze Breitinger, Sylvia Takacova, Vladimir Divoky, Jay L. Hess, Robert K. Slany
Publikováno v:
Cell Reports, Vol 3, Iss 5, Pp 1553-1566 (2013)
Stimulation of transcriptional elongation is a key activity of leukemogenic MLL fusion proteins. Here, we provide evidence that MLL-ENL also inhibits Polycomb-mediated silencing as a prerequisite for efficient transformation. Biochemical studies iden
Externí odkaz:
https://doaj.org/article/640a9373d2684bb197a168258ccb394f
Autor:
Arndt Borkhardt, Robert K. Slany, Lutz Zeitlmann, Katrin Hetzner, Elisa Füller, Mäthner E, Constanze Breitinger, Maria-Paz Garcia-Cuellar
Publikováno v:
Leukemia. 28:1427-1435
Mixed-lineage leukemia fusion proteins activate their target genes predominantly by stimulating transcriptional elongation. A core component necessary for this activity is cyclin-dependent kinase 9. Here we explored the effectiveness of small molecul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f97d036c58c0b41f89be1e37b7a829b7
https://doi.org/10.1038/leu.2014.40
https://doi.org/10.1038/leu.2014.40
Autor:
Emanuel Maethner, Klaus Dieter Fischer, Maria-Paz Garcia-Cuellar, Constanze Breitinger, Robert K. Slany, Schilling K, Alexandra Schambony
Publikováno v:
Leukemia. 27:236-238
HOX genes regulate Rac1 activity in hematopoietic cells through control of Vav2 expression
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dad3d6722a5b473f12b42045c02131ec
https://doi.org/10.1038/leu.2012.166
https://doi.org/10.1038/leu.2012.166
Publikováno v:
Blood. 120(19)
HOX proteins are widely involved in hematopoietic development. These transcription factors combine a conserved DNA-binding homeobox with a divergent N-terminus that mediates interaction with variable cofactors. The resulting combinatorial diversity i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68cb88d3b46e77e160c7e097824f26aa
https://pubmed.ncbi.nlm.nih.gov/22990017
https://pubmed.ncbi.nlm.nih.gov/22990017
Autor:
Emanuel Maethner, Jay L. Hess, Constanze Breitinger, Robert K. Slany, Maria-Paz Garcia-Cuellar
Publikováno v:
Blood. 118:2443-2443
Abstract 2443 MLL fusion proteins are potent leukemogenic agents that are created by chromosomal translocations. These events join the N-terminus of the histone methyltransferase MLL to a variety of different fusion partners. Some time ago we showed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ec648af50362d1547764b1c489f7ea11
https://doi.org/10.1182/blood.v118.21.2443.2443
https://doi.org/10.1182/blood.v118.21.2443.2443
Autor:
Klaus Dieter Fischer, Constanze Breitinger, Maria-Paz Garcia-Cuellar, Robert K. Slany, Alexandra Schambony, Emanuel Maethner, Kirsten Schilling
Publikováno v:
Blood. 118:60-60
Abstract 60 Next to their function in embryogenesis the clustered Hox-homeobox genes are also master regulators of hematopoietic differentiation and development. Perturbed HOX expression can be found in a significant percentage of acute leukemia. Rec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::18d433779423d841f0cc9d27871bc2af
https://doi.org/10.1182/blood.v118.21.60.60
https://doi.org/10.1182/blood.v118.21.60.60
Autor:
Jay L. Hess, Emanuel Maethner, Maria Paz Garcia-Cuellar, Sylvia Takacova, Constanze Breitinger, Robert K. Slany, Vladimir Divoky
Publikováno v:
Cell Reports, Vol 3, Iss 5, Pp 1553-1566 (2013)
Summary Stimulation of transcriptional elongation is a key activity of leukemogenic MLL fusion proteins. Here, we provide evidence that MLL-ENL also inhibits Polycomb-mediated silencing as a prerequisite for efficient transformation. Biochemical stud
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91bb83a643b7559d634ed112d6cbb75e